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001-es BibID:	BIBFORM120767
Első szerző:	Gálné Remenyik Judit (kémia tanár, okleveles vegyész)
Cím:	Exploring the interplay between the core microbiota, physicochemical factors, agrobiochemical cycles in the soil of the historic tokaj mád wine region / Judit Remenyik, László Csige, Péter Dávid, Péter Fauszt,Anna Anita Szilágyi-Rácz, Erzsébet Szőllősi, Zsófia Réka Bacsó, István Szepsy, Krisztina Molnár, Csaba Rácz, Gábor Fidler, Zoltán Kállai, László Stündl, Attila Csaba Dobos, Melinda Paholcsek
Dátum:	2024
ISSN:	1932-6203
Megjegyzések:	A Hungarian survey of Tokaj-Mád vineyards was conducted. Shotgun metabarcoding was applied to decipher the microbial-terroir. The results of 60 soil samples showed that there were three dominant fungal phyla, Ascomycota 66.36% - 15.26%, Basidiomycota 18.78% - 14.90%, Mucoromycota 11.89% - 8.99%, representing 97% of operational taxonomic units (OTUs). Mutual interactions between microbiota diversity and soil physicochemical parameters were revealed. Principal component analysis showed descriptive clustering patterns of microbial taxonomy and resistance gene profiles in the case of the four historic vineyards (Szent Tama? s, Kira? ly, Betsek, Nyu? la?szo? ). Linear discriminant analysis effect size was performed, revealing pronounced shifts in community taxonomy based on soil physicochemical properties. Twelve clades exhibited the most significant shifts (LDA > 4.0), including the phyla Verrucomicrobia, Bacteroidetes, Chloroflexi, and Rokubacteria, the classes Acidobacteria, Deltaproteobacteria, Gemmatimonadetes, and Betaproteobacteria, the order Sphingomonadales, Hypomicrobiales, as well as the family Sphingomonadaceae and the genus Sphingomonas. Three out of the four historic vineyards exhibited the highest occurrences of the bacterial genus Bradyrhizobium, known for its positive influence on plant development and physiology through the secretion of steroid phytohormones. During ripening, the taxonomical composition of the soil fungal microbiota clustered into distinct groups depending on altitude, differences that were not reflected in bacteriomes. Network analyses were performed to unravel changes in fungal interactiomes when comparing postveraison and preharvest samples. In addition to the arbuscular mycorrhiza Glomeraceae, the families Mycosphaerellacae and Rhyzopodaceae and the class Agaricomycetes were found to have important roles in maintaining soil microbial community resilience. Functional metagenomics showed that the soil Na content stimulated several of the microbiota-related agrobiogeochemical cycles, such as nitrogen and sulphur metabolism; steroid, bisphenol, toluene, dioxin and atrazine degradation and the synthesis of folate.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk terroir microbiom NGS
Megjelenés:	Plos One. - 19 : 4 (2024), p. 1-24. -
További szerzők:	Csige László Dávid Péter (1984-) (biológia tanár) Fauszt Péter (1992-) (mikrobiom) Szilágyi-Rácz Anna Anita (1995-) (molekuláris biológus) Szőllősi Erzsébet (1983-) (biológus) Bacsó Zsófia Réka Szepsy István Molnár Krisztina (1981-) Rácz Csaba (1979-) (agrármérnök) Fidler Gábor (1987-) (molekuláris biológus, genetikus) Kállai Zoltán (1986-) (biológus) Stündl László (1970-) (agrármérnök) Dobos Attila (1970-) (agrármérnök) Paholcsek Melinda (1984-) (molekuláris biológus, genetikus)
Pályázati támogatás:	TKP2021-NKTA Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM113646
035-os BibID:	(cikkazonosító)6124 (Scopus)85152306243 (WoS)000968814800001
Első szerző:	Markovics Arnold (molekuláris biológus)
Cím:	HPLC Analysis of Polyphenols Derived from Hungarian Aszú from Tokaj Wine Region and Its Effect on Inflammation in an In Vitro Model System of Endothelial Cells / Arnold Markovics, László Csige, Erzsébet Szőllősi, Hajnalka Matyi, Andrea Diána Lukács, Nóra Réka Perez, Zsófia Réka Bacsó, László Stündl, Judit Remenyik, Attila Biró
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Many studies have been published in recent years regarding the fact that moderate wine consumption, as a part of a balanced diet can have a beneficial effect on human health. The bio- logically active components of wine continue to be the subject of intense research today. In this study, the bioactive molecules of Hungarian aszú from the Tokaj wine region were analyzed using high-performance liquid chromatography (HPLC) and investigated in an in vitro model system of endothelial cells induced by bacterial-derived lipopolysaccharide. The HPLC measurements were performed on a reversed phased column with gradient elution. The non-cytotoxic concentration of the active substance was determined based on 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide (MTT)-, apoptosis, and necrosis assays. The antioxidant effect of the extract was determined by evaluating its ability to eliminate ROS. The expressions of the interleukin-(IL)1?, IL1-?, IL-6, and IL-8 pro-inflammatory cytokines and nitric oxide synthase (eNOS) at the mRNA level were evaluated using a quantitative polymerase chain reaction (qPCR). We found that the lipopolysaccharides (LPS)- induced increases in the expressions of the investigated cytokines were significantly suppressed by Hungarian aszú extract, excluding IL-6. In our experimental setup, our treatment had a positive effect on the eNOS expression, which was impaired as a result of the inflammatory manipulation. In our experimental model, the Hungarian aszú extract decreased the LPS-induced increases in the expression of the investigated cytokines and eNOS at the mRNA level, which presumably had a positive effect on the endothelial dysfunction caused by inflammation due to its strong antioxidant and anti-inflammatory effects. Collectively, this research contributes to a more thorough understanding of the bioactive molecules of aszú from the Tokaj wine region.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 7 (2023), p. 1-14. -
További szerzők:	Csige László Szőllősi Erzsébet (1983-) (biológus) Matyi Hajnalka Lukács Andrea (1989-) (biológus) Perez Nóra Réka Bacsó Zsófia Réka Stündl László (1970-) (agrármérnök) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész) Biró Attila (1988-) (okleveles biomérnök)
Pályázati támogatás:	TKP2021-NKTA-32 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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