CCL

Összesen 2 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM038562
Első szerző:Góth László (analitikus)
Cím:Effects of rs769217 and rs1001179 polymorphisms of catalase gene on blood catalase, carbohydrate and lipid biomarkers in diabetes mellitus / Góth László, Nagy Teréz, Kósa Zsuzsanna, Fejes Zsolt, Harjit Pal Bhattoa, Paragh György, Káplár Miklós
Dátum:2012
ISSN:1071-5762
Megjegyzések:Oxidative stress and deficiency of the enzyme catalase, which is the primary scavenger of the oxidant H(2)O(2), may contribute to diabetes. The current study examined two polymorphisms in the catalase gene, -262C>nT in the promoter and 111C>T in exon 9, and their effects on blood catalase activity as well as on concentrations of blood glucose, haemoglobin A1c, triglyceride, cholesterol, HDL, LDL, ApoA-I and ApoB. Subjects were type-1 and type-2 diabetics. We evaluated PCR-single strand conformational polymorphism for 111C>T and PCR-restriction fragment length polymorphism for -262C>T. TT genotype frequency of 111C>T polymorphism was increased in type-1 diabetes. Type-2 diabetics with the CC or CT genotypes had decreased catalase and increased glucose, hemoglobinA1c and ApoB. Type-2 diabetics who have TT genotype in -262C>T may have elevated risk for diabetes complications; these patients had the lowest mean catalase and HDL, as well as the highest glucose, haemoglobin A1c, cholesterol and ApoB.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Free Radical Research 46 : 10 (2012), p. 1249-1257. -
További szerzők:Nagy Teréz (1971-) (molekuláris biológus) Kósa Zsuzsanna Fejes Zsolt (1988-) (molekuláris biológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Paragh György (1953-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

2.

001-es BibID:BIBFORM023390
Első szerző:Kósa Zsuzsanna
Cím:Catalase - 262C>T polymorphisms in Hungarian vitiligo patients and in controls : further acatalasemia mutations in Hungary / Zsuzsanna Kósa, Zsolt Fejes, Teréz Nagy, Melinda Csordás, Enikő Simics, Éva Remenyik, László Góth
Dátum:2012
Megjegyzések:Catalase is the main regulator of hydrogenperoxide metabolism. In vitiligo patients there areconflicting data on its activity and no data on the effect of-262C[T polymorphism in the catalase gene. Blood catalaseactivity, -262C[T polymorphism and acatalasemiamutations were examined in 75 vitiligo patients and in 162controls, in Hungary. We measured blood catalase activityand conducted analyses with PCR-SSCP, polyacrylamidegel electrophoresis and silver staining in combination withRFLP and nucleotide sequencing. Comparison of the wild(CC) genotype and the mutant (TT) genotype in the vitiligopatients revealed a non significant (P[0.19) increase inblood catalase. Male controls with the CT genotype hadsignificantly (P\0.04) lower blood catalase activity thanCC genotype controls. Female vitiligo patients with CCgenotype had lower (P\0.04) blood catalase than femalecontrols. The frequency of wild genotype (CC) and Calleles is significantly (P\0.04) decreased in Hungariancontrols when compared to controls in Slovenia, Morocco,UK, Greece, Turkey, USA, China. The detection of a novelacatalasemia mutation (37C[T in exon 9) and the 113G[A(exon 9) mutation in Hungary are further proofs of geneticheterogeneity origin of acatalasemia mutations. In conclusion,the -262 C[T polymorphism has a reverse effecton blood catalase in vitiligo patients and in controls. Incontrols the mutant genotypes and alleles are more frequentin Hungary than in several other populations. The newacatalasemia mutations are further examples of heterogeneityof acatalasemia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Acatalasemia
Catalase gene mutations
Screening
RFLP
Vitiligo
Megjelenés:Molecular Biology Reports 39 : 4 (2012), p. 4787-4795. -
További szerzők:Fejes Zsolt (1988-) (molekuláris biológus) Nagy Teréz (1971-) (molekuláris biológus) Csordás Melinda Simics Enikő (bőrgyógyász) Remenyik Éva (1956-) (bőrgyógyász) Góth László (1943-) (analitikus)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1