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1.

001-es BibID:BIBFORM069315
Első szerző:Aiello, Francesca B.
Cím:A role for cytokines in antigen presentation : IL-1 and IL-4 induce accessory functions of antigen-presenting cells / Francesca B. Aiello, Dan L. Longo, Roy Overton, Laszlo Takacs, Scott K. Durum
Dátum:1990
ISSN:0022-1767 1550-6606
Megjegyzések:Fixation of APC with 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (ECDI) eliminates their ability to stimulate proliferation of alloreactive T cells or the D10 T cell clone, although a partial response, IL-4 production, was measured. However, if APC were activated before fixation, they could be ECDI-fixed and retain the ability to induce T cell proliferation. IL-1, IL-4 or LPS were capable of activating APC in this way, whereas IFN-gamma was not. This activation step occurred in 6 h, required protein synthesis, and was distinct from increases in Ia or IL-1. This suggests resting APC lack structures that are essential for inducing T cell proliferation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Immunology. - 144 : 7 (1990), p. 2572-2581. -
További szerzők:Longo, Dan L. Overton, Roy Takács László (1955-) Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM069310
Első szerző:Bristol, Lynn A.
Cím:Characterization of a novel rat thymocyte costimulating antigen by the monoclonal antibody 1.3. / Lynn A. Bristol, Louise Finch, Elena V. Romm, Laszlo Takacs
Dátum:1992
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 148 : 2 (1992), p. 332-338. -
További szerzők:Finch, Louise Romm, Elena V. Takács László (1955-)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM069316
Első szerző:Gotlieb, Walter H.
Cím:Growth of immature (double negative) rat thymocytes in the presence of IL-1 / Walter H. Gotlieb, Laszlo Takacs, Howard A. Young, Luca Gusella, Scott K. Durum
Dátum:1990
Megjegyzések:t is unclear which growth factors, if any, are involved in the growth and differentiation of immature T cells in the thymus. Because IL-1 has been previously implicated in thymocyte proliferation, we examined the effects of IL-1 on precursor thymocytes, the CD4-CD8- or double-negative (DN) cells. We show that IL-1 (together with Con A) is a growth factor for DN, TCR- alpha beta-cells in vitro. After 5 days of culture in IL-1 and Con A, a number of phenotypic changes were observed and two subsets of DN cells were distinguished. One subset expressed full length TCR-alpha and -beta mRNA and surface alpha beta TCR, the other expressed low levels of full length TCR-gamma together with high levels of full length TCR-delta mRNA. Thus, DN cells are induced by IL-1 and Con A to proliferate and express TCR without parallel acquisition of CD4 or CD8 markers. These data suggest that IL-1 drives early steps of intrathymic T cell differentiation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 144 : 6 (1990), p. 2072-2081. -
További szerzők:Takács László (1955-) Young, Howard A. Gusella, Luca Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM069328
Első szerző:Hogg, Nancy
Cím:The p150,95 molecule is a marker of human mononuclear phagocytes : comparison with expression of class II molecules / Nancy Hogg, Laszlo Takacs, David G. Palmer, Yogi Selvendran, Catherine Allen
Dátum:1986
ISSN:0014-2980
Megjegyzések:A new monoclonal antibody (mAb), named 3.9, is described that is specific for the p150,95 molecule, a member of the LFA-1, CR3, p150,95 family of human leukocyte differentiation antigens. The LFA-1 molecule participates in a variety of T cell interactions and the CR3 molecule is the receptor for the complement component iC3b, but little is known about the p150,95 molecule. Here we show that the expression of p150,95 is confined to myeloid cells. mAb 3.9 reacts variably with neutrophils, more strongly with monocytes and is most strongly expressed on tissue macrophages. Using this mAb and others, we have examined the heterogeneity of tissue macrophages. Cells such as Langerhans' cells, dendritic reticulum cells and osteoclasts failed to react with these mAb and thus, probably do not belong to the mononuclear phagocyte lineage. Using a new double-labeling technique, we investigated lymphoid tissue for dendritic cells bearing class II molecules which might function in interactions with T cells. In T cell areas macrophages expressing class II markers were seen but there was no evidence for other types of dendritic or interdigitating cells which expressed class II molecules but not macrophage epitopes. The conclusion from this survey was that the most prominent cell with dendritic morphology found in the T cell areas of lymphoid tissue was a macrophage.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Immunology. - 16 : 3 (1986), p. 240-248. -
További szerzők:Takács László (1955-) Palmer, David G. Selvendran, Yogi Allen, Catherine
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM069314
Első szerző:Oravecz T.
Cím:CD3-induced T-cell proliferation and interleukin-2 secretion is modulated by the CD45 antigen / T. Oravecz, É. Monostori, É. Kurucz, L. Takács, I. Andó
Dátum:1991
ISSN:0300-9475
Megjegyzések:In the present study we have investigated the effect of CD45, CD45RA and CD45RO monoclonal antibodies (MoAbs) on the CD3 receptor-mediated proliferation of human T lymphocytes. It is shown that CD3-induced proliferation of purified resting T cells and quiescent T lymphoblasts (QTL) is promoted via all of the investigated CD45-associated epitopes. It is also shown that the CD45 molecules are required to be cross-linked for costimulation. The MoAbs enhance the interleukin-2 (IL-2) production of CD3-stimulated QTL. The elevation of the IL-2 production correlates with the increase in CD3-induced cell proliferation suggesting that the CD45-driven regulation of T lymphocyte activation is linked to the IL-2 pathway.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Scandinavian Journal of Immunology 34 : 5 (1991), p. 531-537. -
További szerzők:Monostori Éva Kurucz É. Takács László (1955-) Andó István
Internet cím:DOI
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6.

001-es BibID:BIBFORM069357
Első szerző:Sándor Mátyás
Cím:Fc Receptor Expression By Murine Fetal Thymocytes / Sandor, M., Takacs, L., Mueller, A., Lynch, R.
Dátum:1993
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Journal of Immunology. - 150 : 8 (1993), 107. p. -
További szerzők:Takács László (1955-) Mueller, Alfred Lynch, Richard G.
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7.

001-es BibID:BIBFORM069318
Első szerző:Smith, Mark R.
Cím:Direct evidence for an intracellular role for tumor necrosis factor-alpha 1 : microinjection of tumor necrosis factor kills target cells / Mark R. Smith, William E. Munger, Hsiang-Fu Kung, Laszlo Takacs, Scott K. Durum
Dátum:1990
Megjegyzések:TNF-alpha is a small peptide cytokine produced primarily by activated macrophages. One of the many biologic activities of TNF is the killing of diverse types of tumor cells. We considered the possibility that killing was mediated by TNF itself at an intracellular site, subsequent to receptor-mediated endocytosis. To test this hypothesis, we microinjected TNF into various murine normal cells and cell lines, some of which were killed by TNF given by the usual extracellular route, and others that were not. Cytotoxic effects of microinjected TNF were observed in several cell types 2 to 4 h after injection. L929 fibroblasts were killed by either extracellular or intracellular TNF. A TNF-resistant subline of L929 was insensitive to either extracellular or intracellular TNF. L6 fibroblasts were found to be resistant to high doses of TNF given either extracellularly or microinjected. Normal macrophages and the J774 macrophage-like cell line were not killed by extracellular TNF, but were rapidly killed by microinjected TNF. Thus, TNF, an extracellular peptide ligand, has an intracellular activity, suggesting that internalization of this ligand may have important intracellular biochemical roles.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 144 : 1 (1990), p. 162-169. -
További szerzők:Munger, William E. Kung, Hsiang-Fu Takács László (1955-) Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM069333
Első szerző:Takács László
Cím:Detection and localization by the monoclonal anti-interleukin 2 receptor antibody AMT-13 of IL 2 receptor-bearing cells in the developing thymus of the mouse embryo and in the thymus of cortisone-treated mice / Laszlo Takacs, Hisao Osawa, Tibor Diamantstein
Dátum:1984
ISSN:0014-2980
Megjegyzések:During embryonic development of the mouse, before expressing classical T cell markers, the blast cells colonizing the thymus react with the monoclonal antibody AMT-13 shown previously to detect interleukin 2 receptors. The proportion of AMT-13+ cells decreases as gestation time increases. On the other hand, the proportion of Thy-1+, Lyt-1+ and Lyt-2+ cells increases during ontogenesis. On the 19th day of gestation when the thymus architecture is comparable to the adult thymus, the AMT-13+ cells become localized in the subcapsular area of the cortex. In the adult thymus after cortison treatment the regenerating cells express the AMT-13 antigen. The AMT-13 antigen presumably the interleukin 2 receptor is the first marker of the early embryonic thymocytes reported until now that may be related to cellular function.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Immunology 14 : 12 (1984), p. 1152-1156. -
További szerzők:Osawa, Hisao Diamantstein Tibor
Internet cím:DOI
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9.

001-es BibID:BIBFORM069324
Első szerző:Takács László
Cím:Cortical thymocyte differentiation in thymomas : an immunohistologic analysis of the pathologic microenvironment / Laszlo Takacs, Wilson Savino, Eva Monostori, Istvan Ando, Jean-François Bach, Mireille Dardenne
Dátum:1987
Megjegyzések:Four monoclonal antibodies (BH11, T2/30, AG3, and BC3) were produced against different epithelial components of the normal thymus. An immunohistologic study was performed on 13 thymomas by the use of these and other stromal and lymphocyte-specific reagents. The aim of this study was to find possible relationships between the proliferating thymoma epithelial cell type and the T cell composition of thymomas. Our results indicate that cortical T cell differentiation is present in thymomas, and that this differentiation is induced in the absence of detectable levels of MHC class II antigens on the epithelial component in most cases. The role of the MHC class II antigens cannot be excluded, however, because these antigens were always present on macrophages. Analysis of the selected group of thymomas, each of which contained epithelial cells homogeneously stained by at least one of the described monoclonal antibodies, showed that the cortical type T cell inducer capacity of thymomas is independent of the epithelial type predominant in the tumor.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 138 : 3 (1987), p. 687-698. -
További szerzők:Savino, Wilson Monostori Éva Andó István Bach, Jean-François Dardenne, Mireille
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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10.

001-es BibID:BIBFORM069323
Első szerző:Takács László
Cím:IL 1 induction by murine T cell clones : detection of an IL 1-inducing lymphokine / Laszlo Takacs, Jay A. Berzofsky, Jena York-Jolley, Tohru Akahoshi, Elisabetta Blasi, Scott K. Durum
Dátum:1987
Megjegyzések:T cell activation is widely believed to depend on interleukin 1 (IL 1) provided by antigen (Ag)-presenting cells (APC). Because IL 1 is not a constitutive product of APC, we examined the features of its production during the interaction of murine T cell clones and APC. We observed that IL 1 was detectable in supernatants of most myoglobin-specific T cell clones grown with APC and Ag. Two of these T cell clones induced exceptionally high levels of IL 1 in their supernatants, and these same clones demonstrated the unusual restriction to I-Ek, which is a low responder type for sperm whale myoglobin. One of these clones was characterized additionally as to the mechanism of IL 1 induction. This clone rapidly stimulated IL 1 production in the APC population (detectable at 4 hr of co-culture) or in macrophages (M phi) or a M phi-like cell line. IL 1 induction was Ag dependent and H-2 restricted. Induction was radioresistant, both on the part of the T cell and of the IL 1 producer. The IL 1-induction process was attributable to a lymphokine produced by the T cell clone. This lymphokine was distinct from IFN-gamma, TNF and CSF-1 and may account for a principal mechanism of T----APC signalling. The induced IL 1 was the same in size, co-mitogenicity, and pyrogenicity as lipopolysaccharide-induced IL 1.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 138 : 7 (1987), p. 2124-2131. -
További szerzők:Berzofsky, Jay A. York-Jolley, Jena Akahoshi, Tohru Blasi, Elisabetta Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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11.

001-es BibID:BIBFORM069320
Első szerző:Takács László
Cím:Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization : tissue localization of IL-1 mRNA in the normal C57BL/6 mouse / László Takács, Elizabeth J. Kovacs, Mark R. Smith, Howard A. Young, Scott K. Durum
Dátum:1988
Megjegyzések:IL-1 is a cytokine with a wide variety of effects on cells involved in inflammatory and immune responses, hemopoiesis, and bone formation. Many cell types have been shown to produce IL-1 in vitro; however, very little is known about the source and role of IL-1 in vivo. By using in situ hybridization, we examined the tissue distribution of cells containing IL-1 mRNA in normal C57BL/6 mice. The results show that many organs contain IL-1 mRNA-positive cells, but the highest frequency was found in lymphoid organs. The distribution and localization of these cells suggest that many of the IL-1 mRNA-producing cells are tissue macrophages. Organs exposed to environmental Ag and microbial products (lymph nodes, liver, intestine, lung, and uterus) had high frequencies of IL-1 mRNA-producing cells, suggesting that IL-1 is produced in local inflammatory or immune responses in vivo. The production of IL-1 mRNA in the thymus and in the bone marrow suggests that IL-1 is available to play physiologic roles in T cell differentiation and in hemopoiesis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 141 : 9 (1988), p. 3081-3095. -
További szerzők:Kovács Erzsébet J. Smith, Mark R. Young, Howard A. Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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12.

001-es BibID:BIBFORM069319
Első szerző:Takács László
Cím:Immature, double negative (CD4-,CD8-) rat thymocytes do not express IL-2 receptors / László Takács, Francis W. Ruscetti, Elizabeth J. Kovacs, Benedita Rocha, Stephan Brocke, Tibor Diamantstein, Bonnie J. Mathieson
Dátum:1988
Megjegyzések:IL-2R alpha-chain is expressed on a subset of mouse CD4- and CD8-, double negative (DN) thymocytes. This expression of IL-2R alpha-chain on some DN thymocytes in the mouse has led to the proposal that IL-2 might serve as a principal growth and/or differentiation factor for immature thymocytes. However, previous histologic observations have indicated that IL-2R alpha-chain is not expressed on the subcapsular thymic blasts (an area rich in DN cells) in either huma or rat thymus, whereas all three species display IL-2R expression on a few cells in the thymic medulla. Therefore, we characterized rat DN thymocytes to determine whether they contained an IL-2R+ population. The results show that rat thymic DN cells share several characteristics with mouse DN cells. However, most of the rat strains do not express the IL-2R on DN cells as shown either by immunofluorescence or by IL-2 binding and receptor cross-linking. Thus, the rare medullary IL-2R+ cells were not found in the DN cells. Only in the exceptional F344 rat strain is the IL-2R alpha-chain expressed on a major proportion of thymocytes, including both DN cells and small cortical-type thymocytes. Furthermore, rat DN cells do not contain detectable IL-2 mRNA or cytoplasmic IL-2 activity, thus supporting the conclusion that it is unlikely that IL-2 and IL-2R serve to maintain the proliferation of rat DN thymocytes in vivo. The possible significance of in vivo expression of IL-2R alpha-chain on immature thymocytes in the mouse and in a single rat strain is discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 141 : 11 (1988), p. 3810-3818. -
További szerzők:Ruscetti, Francis Kovács Erzsébet J. Rocha, Benedita Brocke, Stephan Diamantstein Tibor Mathieson, Bonnie J.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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