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001-es BibID:	BIBFORM069316
Első szerző:	Gotlieb, Walter H.
Cím:	Growth of immature (double negative) rat thymocytes in the presence of IL-1 / Walter H. Gotlieb, Laszlo Takacs, Howard A. Young, Luca Gusella, Scott K. Durum
Dátum:	1990
Megjegyzések:	t is unclear which growth factors, if any, are involved in the growth and differentiation of immature T cells in the thymus. Because IL-1 has been previously implicated in thymocyte proliferation, we examined the effects of IL-1 on precursor thymocytes, the CD4-CD8- or double-negative (DN) cells. We show that IL-1 (together with Con A) is a growth factor for DN, TCR- alpha beta-cells in vitro. After 5 days of culture in IL-1 and Con A, a number of phenotypic changes were observed and two subsets of DN cells were distinguished. One subset expressed full length TCR-alpha and -beta mRNA and surface alpha beta TCR, the other expressed low levels of full length TCR-gamma together with high levels of full length TCR-delta mRNA. Thus, DN cells are induced by IL-1 and Con A to proliferate and express TCR without parallel acquisition of CD4 or CD8 markers. These data suggest that IL-1 drives early steps of intrathymic T cell differentiation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Immunology 144 : 6 (1990), p. 2072-2081. -
További szerzők:	Takács László (1955-) Young, Howard A. Gusella, Luca Durum, Scott K.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM069346
Első szerző:	Takács László
Cím:	Expression Of Il-1 Alpha-Genes And Beta-Genes Invivo As Analyzed By Insitu Hybridization Histochemistry / Takacs, L., Smith, M., Kovacs, E., Young, H., Durum, S.
Dátum:	1987
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:	Journal of Leukocyte Biology. - 42 : 5 (1987), p. 581-582. -
További szerzők:	Smith, M. Kovács Erzsébet J. Young, Howard A. Durum, Scott K.
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001-es BibID:	BIBFORM069320
Első szerző:	Takács László
Cím:	Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization : tissue localization of IL-1 mRNA in the normal C57BL/6 mouse / László Takács, Elizabeth J. Kovacs, Mark R. Smith, Howard A. Young, Scott K. Durum
Dátum:	1988
Megjegyzések:	IL-1 is a cytokine with a wide variety of effects on cells involved in inflammatory and immune responses, hemopoiesis, and bone formation. Many cell types have been shown to produce IL-1 in vitro; however, very little is known about the source and role of IL-1 in vivo. By using in situ hybridization, we examined the tissue distribution of cells containing IL-1 mRNA in normal C57BL/6 mice. The results show that many organs contain IL-1 mRNA-positive cells, but the highest frequency was found in lymphoid organs. The distribution and localization of these cells suggest that many of the IL-1 mRNA-producing cells are tissue macrophages. Organs exposed to environmental Ag and microbial products (lymph nodes, liver, intestine, lung, and uterus) had high frequencies of IL-1 mRNA-producing cells, suggesting that IL-1 is produced in local inflammatory or immune responses in vivo. The production of IL-1 mRNA in the thymus and in the bone marrow suggests that IL-1 is available to play physiologic roles in T cell differentiation and in hemopoiesis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Immunology 141 : 9 (1988), p. 3081-3095. -
További szerzők:	Kovács Erzsébet J. Smith, Mark R. Young, Howard A. Durum, Scott K.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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