CCL

Összesen 12 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM069315
Első szerző:Aiello, Francesca B.
Cím:A role for cytokines in antigen presentation : IL-1 and IL-4 induce accessory functions of antigen-presenting cells / Francesca B. Aiello, Dan L. Longo, Roy Overton, Laszlo Takacs, Scott K. Durum
Dátum:1990
ISSN:0022-1767 1550-6606
Megjegyzések:Fixation of APC with 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (ECDI) eliminates their ability to stimulate proliferation of alloreactive T cells or the D10 T cell clone, although a partial response, IL-4 production, was measured. However, if APC were activated before fixation, they could be ECDI-fixed and retain the ability to induce T cell proliferation. IL-1, IL-4 or LPS were capable of activating APC in this way, whereas IFN-gamma was not. This activation step occurred in 6 h, required protein synthesis, and was distinct from increases in Ia or IL-1. This suggests resting APC lack structures that are essential for inducing T cell proliferation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Immunology. - 144 : 7 (1990), p. 2572-2581. -
További szerzők:Longo, Dan L. Overton, Roy Takács László (1955-) Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM069285
Első szerző:Aiello, Francesca B.
Cím:Inducible accessory function of a macrophage cell line / F. B. Aiello, L. Gusella, D. L. Longo, M. Birchenall-Roberts, L. Takacs, F. Takei, F. Ruscetti, P. Musiani, S. K. Durum
Dátum:2008
ISSN:0892-3973
Megjegyzések:Costimulatory molecules in addition to occupancy of the T-cell antigenreceptor, are required to induce T-cell proliferation.Previous worksuggested that membrane molecules responsible for costimulatoryactivity were not constitutively expressed on the antigen presenting cell(APC) surface. In the present study, we have identified a clonedmacrophage cell line (FLJ2) with inducible APC function. Theunactivated FLJ2 line could not induce T-cell proliferation. FLJ2 couldpresent alloantigen, and stimulate proliferation of either a T-cell clone ornormal resting T cells following activation with IFN y or unexpectedlywith lipopolysaccaride (LPS)-Activated FLJ2 cells could be fixed andAPC function was preserved. The relevant inducible molecules requiredfor APC function appeared distinct from la and IL1. The expression ofICAM-1 and LFA-1 was increased during activation and anti-LFA-1 antibody blocked APC function. This suggests that one important featureof the activation process may be improvement of cellular adhesion.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunopharmacology and Immunotoxicology. - 15 : 4 (2008), p. 327-353. -
További szerzők:Gusella, Luca Longo, Dan L. Birchenall-Roberts, M. Takács László (1955-) Takei, F. Ruscetti, Francis Musiani, P. Durum, Scott K.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM069344
Első szerző:Durum, Scott K.
Cím:T-Cell Clone Producing Il-1-Like Activity Following Stimulation By Antigen-Presenting B-Cells / Durum, S., Kovacs, E., Takacs, L., Tartakovsky, B.
Dátum:1986
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Federation Proceedings. - 45 : 3 (1986), 716. p. -
További szerzők:Kovács Erzsébet J. Takács László (1955-) Tartakovsky, Boris
Borító:

4.

001-es BibID:BIBFORM069316
Első szerző:Gotlieb, Walter H.
Cím:Growth of immature (double negative) rat thymocytes in the presence of IL-1 / Walter H. Gotlieb, Laszlo Takacs, Howard A. Young, Luca Gusella, Scott K. Durum
Dátum:1990
Megjegyzések:t is unclear which growth factors, if any, are involved in the growth and differentiation of immature T cells in the thymus. Because IL-1 has been previously implicated in thymocyte proliferation, we examined the effects of IL-1 on precursor thymocytes, the CD4-CD8- or double-negative (DN) cells. We show that IL-1 (together with Con A) is a growth factor for DN, TCR- alpha beta-cells in vitro. After 5 days of culture in IL-1 and Con A, a number of phenotypic changes were observed and two subsets of DN cells were distinguished. One subset expressed full length TCR-alpha and -beta mRNA and surface alpha beta TCR, the other expressed low levels of full length TCR-gamma together with high levels of full length TCR-delta mRNA. Thus, DN cells are induced by IL-1 and Con A to proliferate and express TCR without parallel acquisition of CD4 or CD8 markers. These data suggest that IL-1 drives early steps of intrathymic T cell differentiation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 144 : 6 (1990), p. 2072-2081. -
További szerzők:Takács László (1955-) Young, Howard A. Gusella, Luca Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM069313
Első szerző:Gotlieb, Walter H.
Cím:CD8 gamma delta cells : presence in the adult rat thymus and generation in vitro from CD4-/CD8- thymocytes in the presence of interleukin 2 / Walter H. Gotlieb, Laszlo Takacs, Louise R. Finch, William Kopp, Allan M. Weissman, Scott K. Durum
Dátum:1991
ISSN:1043-4666
Megjegyzések:Three to fifteen percent of peripheral T cells in adults express the recently described gamma delta T-cell antigen receptor (TcR) heterodimer. A small subpopulation of gamma delta cells express the CD8 accessory molecule. In this study, we analyzed the potential of highly purified CD4-/CD8-, double negative (DN) rat precursor thymocytes to give rise to gamma delta cells. We observed that in the presence of interleukin 2 (IL-2) and concanavalin A (ConA), both DN and CD8 cells expressing the gamma delta TcR were generated in vitro. We then examined the rat thymus for these cells and confirmed the presence of a previously undescribed CD8 TcR-alpha beta- subset in the rat thymus, expressing high levels of TcR-gamma and delta messages with no detectable TcR-alpha transcripts, similar to the cells generated in vitro in the presence of IL-2 and ConA.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cytokine. - 3 : 6 (1991), p. 598-608. -
További szerzők:Takács László (1955-) Finch, Louise Kopp, William Weissman, Allan M. Durum, Scott K.
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM069281
Első szerző:Gotlieb, Walter H.
Cím:Upregulation of T cell receptor gamma chain transcription by interleukin-2 / Walter H. Gotlieb, Lynn A. Bristol, Allan M. Weissman, Scott K. Durum, László Takács
Dátum:1993
ISSN:0008-8749
Megjegyzések:Signals involved in TcR gene rearrangement and expression are poorly understood. The ability of interleukin 2 to control TcR gamma gene expression was examined. Precursor thymocytes grown in the presence of IL-1 and Con A develop to CD3+ T cells that express either the TcR alpha/beta or gamma/delta complex on the cell surface (1). We show here that a major subpopulation of these cells are CD4-/CD8-, gamma/delta cells expressing only low levels of TcR gamma transcripts, compared to TcR delta mRnA or to TcR gamma mRNA of gamma/delta cells grown from precursor thymocytes with IL-2 and Con A. The cells cultured with IL-1 and lectin then strongly reacted to IL-2 by upregulating the steady-state level of TcR gamma mRNA. Our findings indicate that IL-2 upregulates TcR gamma transcription by transcriptional regulatory effects in this in vitro system.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cellular Immunology. - 151 : 2 (1993), p. 345-355. -
További szerzők:Bristol, Lynn A. Weissman, Allan M. Durum, Scott K. Takács László (1955-)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM069318
Első szerző:Smith, Mark R.
Cím:Direct evidence for an intracellular role for tumor necrosis factor-alpha 1 : microinjection of tumor necrosis factor kills target cells / Mark R. Smith, William E. Munger, Hsiang-Fu Kung, Laszlo Takacs, Scott K. Durum
Dátum:1990
Megjegyzések:TNF-alpha is a small peptide cytokine produced primarily by activated macrophages. One of the many biologic activities of TNF is the killing of diverse types of tumor cells. We considered the possibility that killing was mediated by TNF itself at an intracellular site, subsequent to receptor-mediated endocytosis. To test this hypothesis, we microinjected TNF into various murine normal cells and cell lines, some of which were killed by TNF given by the usual extracellular route, and others that were not. Cytotoxic effects of microinjected TNF were observed in several cell types 2 to 4 h after injection. L929 fibroblasts were killed by either extracellular or intracellular TNF. A TNF-resistant subline of L929 was insensitive to either extracellular or intracellular TNF. L6 fibroblasts were found to be resistant to high doses of TNF given either extracellularly or microinjected. Normal macrophages and the J774 macrophage-like cell line were not killed by extracellular TNF, but were rapidly killed by microinjected TNF. Thus, TNF, an extracellular peptide ligand, has an intracellular activity, suggesting that internalization of this ligand may have important intracellular biochemical roles.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 144 : 1 (1990), p. 162-169. -
További szerzők:Munger, William E. Kung, Hsiang-Fu Takács László (1955-) Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM069354
Első szerző:Takács László
Cím:Il-2 Selectively Up-Regulates Tcr Gamma Chain Gene-Transcription In Rat Gamma-Delta-T-Cells / Takacs, L., Gotlieb, W., Bristol, L., Durum, S., & Weissman, A.
Dátum:1991
ISSN:0892-6638
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Faseb Journal. - 5 : 6 (1991), 1698. p. -
További szerzők:Gotlieb, Walter H. Bristol, Lynn A. Durum, Scott K. Weissman, Allan M.
Borító:

9.

001-es BibID:BIBFORM069346
Első szerző:Takács László
Cím:Expression Of Il-1 Alpha-Genes And Beta-Genes Invivo As Analyzed By Insitu Hybridization Histochemistry / Takacs, L., Smith, M., Kovacs, E., Young, H., Durum, S.
Dátum:1987
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Journal of Leukocyte Biology. - 42 : 5 (1987), p. 581-582. -
További szerzők:Smith, M. Kovács Erzsébet J. Young, Howard A. Durum, Scott K.
Borító:

10.

001-es BibID:BIBFORM069323
Első szerző:Takács László
Cím:IL 1 induction by murine T cell clones : detection of an IL 1-inducing lymphokine / Laszlo Takacs, Jay A. Berzofsky, Jena York-Jolley, Tohru Akahoshi, Elisabetta Blasi, Scott K. Durum
Dátum:1987
Megjegyzések:T cell activation is widely believed to depend on interleukin 1 (IL 1) provided by antigen (Ag)-presenting cells (APC). Because IL 1 is not a constitutive product of APC, we examined the features of its production during the interaction of murine T cell clones and APC. We observed that IL 1 was detectable in supernatants of most myoglobin-specific T cell clones grown with APC and Ag. Two of these T cell clones induced exceptionally high levels of IL 1 in their supernatants, and these same clones demonstrated the unusual restriction to I-Ek, which is a low responder type for sperm whale myoglobin. One of these clones was characterized additionally as to the mechanism of IL 1 induction. This clone rapidly stimulated IL 1 production in the APC population (detectable at 4 hr of co-culture) or in macrophages (M phi) or a M phi-like cell line. IL 1 induction was Ag dependent and H-2 restricted. Induction was radioresistant, both on the part of the T cell and of the IL 1 producer. The IL 1-induction process was attributable to a lymphokine produced by the T cell clone. This lymphokine was distinct from IFN-gamma, TNF and CSF-1 and may account for a principal mechanism of T----APC signalling. The induced IL 1 was the same in size, co-mitogenicity, and pyrogenicity as lipopolysaccharide-induced IL 1.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 138 : 7 (1987), p. 2124-2131. -
További szerzők:Berzofsky, Jay A. York-Jolley, Jena Akahoshi, Tohru Blasi, Elisabetta Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM069320
Első szerző:Takács László
Cím:Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization : tissue localization of IL-1 mRNA in the normal C57BL/6 mouse / László Takács, Elizabeth J. Kovacs, Mark R. Smith, Howard A. Young, Scott K. Durum
Dátum:1988
Megjegyzések:IL-1 is a cytokine with a wide variety of effects on cells involved in inflammatory and immune responses, hemopoiesis, and bone formation. Many cell types have been shown to produce IL-1 in vitro; however, very little is known about the source and role of IL-1 in vivo. By using in situ hybridization, we examined the tissue distribution of cells containing IL-1 mRNA in normal C57BL/6 mice. The results show that many organs contain IL-1 mRNA-positive cells, but the highest frequency was found in lymphoid organs. The distribution and localization of these cells suggest that many of the IL-1 mRNA-producing cells are tissue macrophages. Organs exposed to environmental Ag and microbial products (lymph nodes, liver, intestine, lung, and uterus) had high frequencies of IL-1 mRNA-producing cells, suggesting that IL-1 is produced in local inflammatory or immune responses in vivo. The production of IL-1 mRNA in the thymus and in the bone marrow suggests that IL-1 is available to play physiologic roles in T cell differentiation and in hemopoiesis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 141 : 9 (1988), p. 3081-3095. -
További szerzők:Kovács Erzsébet J. Smith, Mark R. Young, Howard A. Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM069327
Első szerző:Tartakovsky, Boris
Cím:T cell clone producing an IL 1-like activity after stimulation by antigen-presenting B cells / Boris Tartakovsky, Elizabeth J. Kovacs, Laszlo Takacs, Scott K. Durum
Dátum:1986
Megjegyzések:We have analyzed the involvement of IL 1 in a cellular interaction during which murine B cells serve as antigen-presenting cells for a T cell clone (D10.G4.1). This T cell clone was chosen for study because it is highly dependent on exogenous IL 1 for concanavalin A (or anti-receptor antibody)-induced proliferation. We observed that B cells presented either self I-Ak plus nominal antigen or allogeneic I-Ab, and consequently induced proliferation of this T cell clone without any requirement for exogenous IL 1. After an overnight co-culture with allogenic B cells, we detected an IL 1-like activity in lysates of the cell mixture, but were unable to detect a similar activity in the culture medium. This IL 1-like activity was induced in a MHC-restricted manner. We determined that this intracellular IL 1-like activity was derived from the D10.G4.1-responding T cells, rather than from the antigen-presenting B cells. Moreover, we were unable to detect an IL 1-like activity in murine B cells after a variety of stimuli including LPS, anti-Ig, activated T cell supernatants, or combinations of these stimuli. Hybridization of cytoplasmic RNA with an oligonucleotide probe for human IL 1-alpha confirmed the T cell source of the biological activity. The IL 1-like factor derived from the cell culture mixture lysate showed two broad peaks of activity after gel filtration, one in the 10,000 to 20,000 dalton range and the second in the 35,000 to 45,000 dalton range. This first description of IL 1 activity produced by a T cell may introduce a new element to the early events leading to T cell activation and proliferation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 137 : 1 (1986), p. 160-166. -
További szerzők:Kovács Erzsébet J. Takács László (1955-) Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.