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001-es BibID:BIBFORM069315
Első szerző:Aiello, Francesca B.
Cím:A role for cytokines in antigen presentation : IL-1 and IL-4 induce accessory functions of antigen-presenting cells / Francesca B. Aiello, Dan L. Longo, Roy Overton, Laszlo Takacs, Scott K. Durum
Dátum:1990
ISSN:0022-1767 1550-6606
Megjegyzések:Fixation of APC with 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (ECDI) eliminates their ability to stimulate proliferation of alloreactive T cells or the D10 T cell clone, although a partial response, IL-4 production, was measured. However, if APC were activated before fixation, they could be ECDI-fixed and retain the ability to induce T cell proliferation. IL-1, IL-4 or LPS were capable of activating APC in this way, whereas IFN-gamma was not. This activation step occurred in 6 h, required protein synthesis, and was distinct from increases in Ia or IL-1. This suggests resting APC lack structures that are essential for inducing T cell proliferation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Immunology. - 144 : 7 (1990), p. 2572-2581. -
További szerzők:Longo, Dan L. Overton, Roy Takács László (1955-) Durum, Scott K.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:BIBFORM069285
Első szerző:Aiello, Francesca B.
Cím:Inducible accessory function of a macrophage cell line / F. B. Aiello, L. Gusella, D. L. Longo, M. Birchenall-Roberts, L. Takacs, F. Takei, F. Ruscetti, P. Musiani, S. K. Durum
Dátum:2008
ISSN:0892-3973
Megjegyzések:Costimulatory molecules in addition to occupancy of the T-cell antigenreceptor, are required to induce T-cell proliferation.Previous worksuggested that membrane molecules responsible for costimulatoryactivity were not constitutively expressed on the antigen presenting cell(APC) surface. In the present study, we have identified a clonedmacrophage cell line (FLJ2) with inducible APC function. Theunactivated FLJ2 line could not induce T-cell proliferation. FLJ2 couldpresent alloantigen, and stimulate proliferation of either a T-cell clone ornormal resting T cells following activation with IFN y or unexpectedlywith lipopolysaccaride (LPS)-Activated FLJ2 cells could be fixed andAPC function was preserved. The relevant inducible molecules requiredfor APC function appeared distinct from la and IL1. The expression ofICAM-1 and LFA-1 was increased during activation and anti-LFA-1 antibody blocked APC function. This suggests that one important featureof the activation process may be improvement of cellular adhesion.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunopharmacology and Immunotoxicology. - 15 : 4 (2008), p. 327-353. -
További szerzők:Gusella, Luca Longo, Dan L. Birchenall-Roberts, M. Takács László (1955-) Takei, F. Ruscetti, Francis Musiani, P. Durum, Scott K.
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Intézményi repozitóriumban (DEA) tárolt változat
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