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001-es BibID:BIBFORM069285
Első szerző:Aiello, Francesca B.
Cím:Inducible accessory function of a macrophage cell line / F. B. Aiello, L. Gusella, D. L. Longo, M. Birchenall-Roberts, L. Takacs, F. Takei, F. Ruscetti, P. Musiani, S. K. Durum
Dátum:2008
ISSN:0892-3973
Megjegyzések:Costimulatory molecules in addition to occupancy of the T-cell antigenreceptor, are required to induce T-cell proliferation.Previous worksuggested that membrane molecules responsible for costimulatoryactivity were not constitutively expressed on the antigen presenting cell(APC) surface. In the present study, we have identified a clonedmacrophage cell line (FLJ2) with inducible APC function. Theunactivated FLJ2 line could not induce T-cell proliferation. FLJ2 couldpresent alloantigen, and stimulate proliferation of either a T-cell clone ornormal resting T cells following activation with IFN y or unexpectedlywith lipopolysaccaride (LPS)-Activated FLJ2 cells could be fixed andAPC function was preserved. The relevant inducible molecules requiredfor APC function appeared distinct from la and IL1. The expression ofICAM-1 and LFA-1 was increased during activation and anti-LFA-1 antibody blocked APC function. This suggests that one important featureof the activation process may be improvement of cellular adhesion.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunopharmacology and Immunotoxicology. - 15 : 4 (2008), p. 327-353. -
További szerzők:Gusella, Luca Longo, Dan L. Birchenall-Roberts, M. Takács László (1955-) Takei, F. Ruscetti, Francis Musiani, P. Durum, Scott K.
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2.

001-es BibID:BIBFORM069347
Első szerző:Takács László
Cím:The Analysis of The Role of Il-2 And Il-2 Receptors in The Rat Thymus / Takacs, L., Brocke, S., Kovacs, E., Mathieson, B., Ruscetti, F., Rocha, B.
Dátum:1987
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Lymphokine Research. - 6 : 6 (1987), 124. p. -
További szerzők:Brocke, Stephan Kovács Erzsébet J. Mathieson, Bonnie J. Ruscetti, Francis Rocha, Benedita
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3.

001-es BibID:BIBFORM069319
Első szerző:Takács László
Cím:Immature, double negative (CD4-,CD8-) rat thymocytes do not express IL-2 receptors / László Takács, Francis W. Ruscetti, Elizabeth J. Kovacs, Benedita Rocha, Stephan Brocke, Tibor Diamantstein, Bonnie J. Mathieson
Dátum:1988
Megjegyzések:IL-2R alpha-chain is expressed on a subset of mouse CD4- and CD8-, double negative (DN) thymocytes. This expression of IL-2R alpha-chain on some DN thymocytes in the mouse has led to the proposal that IL-2 might serve as a principal growth and/or differentiation factor for immature thymocytes. However, previous histologic observations have indicated that IL-2R alpha-chain is not expressed on the subcapsular thymic blasts (an area rich in DN cells) in either huma or rat thymus, whereas all three species display IL-2R expression on a few cells in the thymic medulla. Therefore, we characterized rat DN thymocytes to determine whether they contained an IL-2R+ population. The results show that rat thymic DN cells share several characteristics with mouse DN cells. However, most of the rat strains do not express the IL-2R on DN cells as shown either by immunofluorescence or by IL-2 binding and receptor cross-linking. Thus, the rare medullary IL-2R+ cells were not found in the DN cells. Only in the exceptional F344 rat strain is the IL-2R alpha-chain expressed on a major proportion of thymocytes, including both DN cells and small cortical-type thymocytes. Furthermore, rat DN cells do not contain detectable IL-2 mRNA or cytoplasmic IL-2 activity, thus supporting the conclusion that it is unlikely that IL-2 and IL-2R serve to maintain the proliferation of rat DN thymocytes in vivo. The possible significance of in vivo expression of IL-2R alpha-chain on immature thymocytes in the mouse and in a single rat strain is discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Immunology 141 : 11 (1988), p. 3810-3818. -
További szerzők:Ruscetti, Francis Kovács Erzsébet J. Rocha, Benedita Brocke, Stephan Diamantstein Tibor Mathieson, Bonnie J.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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