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001-es BibID:	BIBFORM069322
Első szerző:	Brocke, Stephan
Cím:	The ontogeny of the interleukin 2 receptor expression and of the interleukin 2 responsiveness in the rat thymus / S. Brocke, L. Takacs, J. Gerdes, H. Osawa, T. Diamantstein
Dátum:	1987
ISSN:	0171-2985
Megjegyzések:	The ontogeny of the interleukin 2 receptor (IL 2 R) expression and of the IL 2 responsiveness has been investigated in the rat thymus. In tissue sections, IL 2 R-bearing cells were first detected at day 16 of gestation using the anti-IL 2 R mAb ART-18. In contrast to mice, IL 2 R-bearing cells of the rat are localized mainly in the thymic medulla from the first day of the corticomedullary compartimentalization, and not in the cortex. They are found in regions with a high expression of MHC class II antigens. The proportion of IL 2 R-bearing cells increases during gestation, reaches a peak at the first day after birth and declines to the adult level in the following weeks. The appearance of medullary localized IL 2 R-bearing cells is paralleled with the capacity of the thymocytes to proliferate in response to IL 2 without any additional stimuli.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Immunobiology 174 : 3 (1987), p. 266-273. -
További szerzők:	Takács László (1955-) Gerdes, J. Osawa, Hisao Diamantstein Tibor
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM069347
Első szerző:	Takács László
Cím:	The Analysis of The Role of Il-2 And Il-2 Receptors in The Rat Thymus / Takacs, L., Brocke, S., Kovacs, E., Mathieson, B., Ruscetti, F., Rocha, B.
Dátum:	1987
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:	Lymphokine Research. - 6 : 6 (1987), 124. p. -
További szerzők:	Brocke, Stephan Kovács Erzsébet J. Mathieson, Bonnie J. Ruscetti, Francis Rocha, Benedita
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001-es BibID:	BIBFORM069319
Első szerző:	Takács László
Cím:	Immature, double negative (CD4-,CD8-) rat thymocytes do not express IL-2 receptors / László Takács, Francis W. Ruscetti, Elizabeth J. Kovacs, Benedita Rocha, Stephan Brocke, Tibor Diamantstein, Bonnie J. Mathieson
Dátum:	1988
Megjegyzések:	IL-2R alpha-chain is expressed on a subset of mouse CD4- and CD8-, double negative (DN) thymocytes. This expression of IL-2R alpha-chain on some DN thymocytes in the mouse has led to the proposal that IL-2 might serve as a principal growth and/or differentiation factor for immature thymocytes. However, previous histologic observations have indicated that IL-2R alpha-chain is not expressed on the subcapsular thymic blasts (an area rich in DN cells) in either huma or rat thymus, whereas all three species display IL-2R expression on a few cells in the thymic medulla. Therefore, we characterized rat DN thymocytes to determine whether they contained an IL-2R+ population. The results show that rat thymic DN cells share several characteristics with mouse DN cells. However, most of the rat strains do not express the IL-2R on DN cells as shown either by immunofluorescence or by IL-2 binding and receptor cross-linking. Thus, the rare medullary IL-2R+ cells were not found in the DN cells. Only in the exceptional F344 rat strain is the IL-2R alpha-chain expressed on a major proportion of thymocytes, including both DN cells and small cortical-type thymocytes. Furthermore, rat DN cells do not contain detectable IL-2 mRNA or cytoplasmic IL-2 activity, thus supporting the conclusion that it is unlikely that IL-2 and IL-2R serve to maintain the proliferation of rat DN thymocytes in vivo. The possible significance of in vivo expression of IL-2R alpha-chain on immature thymocytes in the mouse and in a single rat strain is discussed.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Immunology 141 : 11 (1988), p. 3810-3818. -
További szerzők:	Ruscetti, Francis Kovács Erzsébet J. Rocha, Benedita Brocke, Stephan Diamantstein Tibor Mathieson, Bonnie J.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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