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1.

001-es BibID:BIBFORM069322
Első szerző:Brocke, Stephan
Cím:The ontogeny of the interleukin 2 receptor expression and of the interleukin 2 responsiveness in the rat thymus / S. Brocke, L. Takacs, J. Gerdes, H. Osawa, T. Diamantstein
Dátum:1987
ISSN:0171-2985
Megjegyzések:The ontogeny of the interleukin 2 receptor (IL 2 R) expression and of the IL 2 responsiveness has been investigated in the rat thymus. In tissue sections, IL 2 R-bearing cells were first detected at day 16 of gestation using the anti-IL 2 R mAb ART-18. In contrast to mice, IL 2 R-bearing cells of the rat are localized mainly in the thymic medulla from the first day of the corticomedullary compartimentalization, and not in the cortex. They are found in regions with a high expression of MHC class II antigens. The proportion of IL 2 R-bearing cells increases during gestation, reaches a peak at the first day after birth and declines to the adult level in the following weeks. The appearance of medullary localized IL 2 R-bearing cells is paralleled with the capacity of the thymocytes to proliferate in response to IL 2 without any additional stimuli.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunobiology 174 : 3 (1987), p. 266-273. -
További szerzők:Takács László (1955-) Gerdes, J. Osawa, Hisao Diamantstein Tibor
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM069341
Első szerző:Takács László
Cím:Il-2 Receptor Bearing Cell During Ontogenesis Of The Murine Thymus / Takacs, L., Osawa, H., Diamantstein, T.
Dátum:1984
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Lymphokine Research 3 : 4 (1984), 275. p. -
További szerzők:Osawa, Hisao Diamantstein Tibor
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3.

001-es BibID:BIBFORM069333
Első szerző:Takács László
Cím:Detection and localization by the monoclonal anti-interleukin 2 receptor antibody AMT-13 of IL 2 receptor-bearing cells in the developing thymus of the mouse embryo and in the thymus of cortisone-treated mice / Laszlo Takacs, Hisao Osawa, Tibor Diamantstein
Dátum:1984
ISSN:0014-2980
Megjegyzések:During embryonic development of the mouse, before expressing classical T cell markers, the blast cells colonizing the thymus react with the monoclonal antibody AMT-13 shown previously to detect interleukin 2 receptors. The proportion of AMT-13+ cells decreases as gestation time increases. On the other hand, the proportion of Thy-1+, Lyt-1+ and Lyt-2+ cells increases during ontogenesis. On the 19th day of gestation when the thymus architecture is comparable to the adult thymus, the AMT-13+ cells become localized in the subcapsular area of the cortex. In the adult thymus after cortison treatment the regenerating cells express the AMT-13 antigen. The AMT-13 antigen presumably the interleukin 2 receptor is the first marker of the early embryonic thymocytes reported until now that may be related to cellular function.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Immunology 14 : 12 (1984), p. 1152-1156. -
További szerzők:Osawa, Hisao Diamantstein Tibor
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM069332
Első szerző:Takács László
Cím:Immunohistochemical localization of cells reacting with monoclonal antibodies directed against the interleukin-2 receptor of murine, rat and human origin / L. Takacs, H. Osawa, I. Törö, T. Diamantstein
Dátum:1984
ISSN:0009-9104
Megjegyzések:Recently, species specific monoclonal antibodies, directed against the interleukin-2 (IL-2) receptor of murine, rat and human origin, have been produced. In this study we demonstrate with immunohistological methods that cells reacting with these antibodies are present in normal primary and secondary lymphatic organs. The cells are exclusively localized in T cell-dependent areas, and their number increased as a result of immunization.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical and Experimental Immunology 59 : 1 (1984), p. 37-44. -
További szerzők:Osawa, Hisao Törő Imre (1900-1993) (anatómus, biológus) Diamantstein Tibor
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM069326
Első szerző:Takács László
Cím:Cells reacting with the monoclonal anti-IL-2 receptor antibody AMT-13 in the regenerating thymus of irradiated mice / L. Takacs, H. Osawa, K. Liszka, T. Diamantstein
Dátum:1986
ISSN:0009-9104
Megjegyzések:The proportion and anatomical localization in murine thymus of T cell subpopulations, including those which are defined by the monoclonal anti-interleukin 2 (anti-IL-2) receptor antibody AMT-13, were studied by flow cytofluorometry and by immunohistochemical methods, both in irradiated and in normal mice. As a consequence of irradiation the proportion of AMT-13 positive cells and that of Lyt-1 positive cells were markedly enhanced, while the proportion of Lyt-2 positive cells was reduced. The vast majority of the AMT-13 positive cells both in normal and in irradiated thymi were located in the subcapsular area of the thymic cortex, whereas the irradiation resistant Lyt-1 positive cells were located in the medulla. These findings are compatible with the view that, similar to the developing thymus in the mouse embryo, in the regenerating adult thymus, AMT-13+ cells include the activated pro-thymocytes that repopulate the irradiated thymus.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical and Experimental Immunology 64 : 2 (1986), p. 342-342. -
További szerzők:Osawa, Hisao Liszka K. Diamantstein Tibor
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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