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001-es BibID:BIBFORM069339
Első szerző:Loc, N. K.
Cím:Effects of cyclophosphamide on the rat's mesenteric lymph node / Loc, N. K., Oláh, I., Kittner, Z., Takacs, L., Törö, I.
Dátum:1980
ISSN:0001-6217
Megjegyzések:A single large dose (200 mg) of cyclophosphamide (Cy) given to adult rats caused a drastic depletion of lymphocytes occurring earlier in the B dependent compartment than in the T dependent one of the lymph node cortex. The drug had a somewhat facilitating effect on the early differentiation of plasma cells (between 12 and 24 h) which later were also depleted. By Cy administration two types of macrophage were distinguished morphologically and topographically in the lymph nodes. Cy effect the endothelial cells lining the blood vessels and lymph sinuses. From day 4 to 7 Cy caused a constant flooding of red blood cells into the lymph node sinuses like in the normal rat haemolymph gland. Regeneration of the mesenteric lymph nodes occurred by a repopulation of lymphoid cells and a proliferation of other cell types. Repopulation of the B dependent compartment lagged behind that of the T dependent compartment. Regeneration of endothelial cells seemed to be one of the factors facilitating the repopulation of lymphoid cells. The distribution of T and B dependent cells in different compartments of the rat lymph node and activation of mononuclear phagocytes in Cy treated rat lymph node are discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Megjelenés:Acta morphologica Academiae Scientiarum Hungaricae. - 29 : 4 (1980), p. 335-351. -
További szerzők:Oláh I. Kittner Zsuzsa Takács László (1955-) Törő Imre (1900-1993) (anatómus, biológus)
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2.

001-es BibID:BIBFORM069338
Első szerző:Loc, N. K.
Cím:Effect of cyclophosphamide on the rat thymus / Loc, N. K., Olah, I., Takacs, L., Kittner, Z, Törö, I.
Dátum:1980
ISSN:0001-6217
Megjegyzések:A single large dose (200 mg/kg) of cyclophosphamide (Cy) caused thymic involution. Thymic cortex was almost depleted of lymphocytes while medullary thymocytes were not affected. This resulted in thymic inversion on day 4. During the period of involution the cortex was invaded by positive acid phosphatase granules containing macrophages. Later the cytoplasms of these macrophages were loaded with lipid droplets and residual materials. Extensive vacuolization of the cytoplasms of epithelial and special cells were revealed. Regeneration began on day 4. Repopulating cells appeared primarily in subcapsular region. Regeneration was complete by day 11 as examined by morphological technics. While FCS dependent rosette formation capacity remained below the control level even on day 16.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Megjelenés:Acta Morphologica Academiae Scientiarum Hungaricae 29 : 4 (1980), p. 319-333. -
További szerzők:Oláh I. Takács László (1955-) Kittner Zsuzsa Törő Imre (1900-1993) (anatómus, biológus)
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