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001-es BibID:	BIBFORM054574
035-os BibID:	PMID: 25061872
Első szerző:	Oláh Attila (élettanász)
Cím:	Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes / Attila Oláh, Balázs I. Tóth, István Borbíró, Koji Sugawara, Attila G. Szöllősi, Gabriella Czifra, Balázs Pál, Lídia Ambrus, Jennifer Kloepper, Emanuela Camera, Matteo Ludovici, Mauro Picardo, Thomas Voets, Christos C. Zouboulis, Ralf Paus, Tamás Bíró
Dátum:	2014
ISSN:	0021-9738
Megjegyzések:	The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-KB signaling. Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Clinical Investigation. - 124 : 9 (2014), p. 3713-3724. -
További szerzők:	Tóth István Balázs (1978-) (élettanász) Borbíró István (1982-) (biokémikus, molekuláris biológus) Sugawara, Koji Szöllősi Attila Gábor (1982-) (élettanász) Czifra Gabriella (1975-) (élettanász) Pál Balázs (1975-) (élettanász) Ambrus Lídia (1986-) (élettanász) Kloepper, Jennifer E. Camera, Emanuela Ludovici, Matteo Picardo, Mauro Voets, Thomas Zouboulis, Christos C. (1960-) (bőrgyógyász) Paus, Ralf Bíró Tamás (1968-) (élettanász)
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001-es BibID:	BIBFORM105072
035-os BibID:	(cikkazonosító)1029818 (Scopus)85142633292 (WOS)000889955400001 (PubMed)36439142
Első szerző:	Zouboulis, Christos C. (bőrgyógyász)
Cím:	Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations / Zouboulis Christos C., Coenye Tom, He Li, Kabashima Kenji, Kobayashi Tetsuro, Niemann Catherin, Nomura Takashi, Oláh Attila, Picardo Mauro, Quist Sven R., Sasano Hironobu, Schneider Marlon R., Törőcsik Daniel, Wong Sunny Y.
Dátum:	2022
ISSN:	1664-3224
Megjegyzések:	This review presents several aspects of the innovative concept of sebaceous immunobiology, which summarizes the numerous activities of the sebaceous gland including its classical physiological and pathophysiological tasks, namely sebum production and the development of seborrhea and acne. Sebaceous lipids, which represent 90% of the skin surface lipids in adolescents and adults, are markedly involved in the skin barrier function and perifollicular and dermal innate immune processes, leading to inflammatory skin diseases. Innovative experimental techniques using stem cell and sebocyte models have clarified the roles of distinct stem cells in sebaceous gland physiology and sebocyte function control mechanisms. The sebaceous gland represents an integral part of the pilosebaceous unit and its status is connected to hair follicle morphogenesis. Interestingly, professional inflammatory cells contribute to sebocyte differentiation and homeostasis, whereas the regulation of sebaceous gland function by immune cells is antigen-independent. Inflammation is involved in the very earliest differentiation changes of the pilosebaceous unit in acne. Sebocytes behave as potent immune regulators, integrating into the innate immune responses of the skin. Expressing inflammatory mediators, sebocytes also contribute to the polarization of cutaneous T cells towards the Th17 phenotype. In addition, the immune response of the perifollicular infiltrate depends on factors produced by the sebaceous glands, mostly sebaceous lipids. Human sebocytes in vitro express functional pattern recognition receptors, which are likely to interact with bacteria in acne pathogenesis. Sex steroids, peroxisome proliferatoractivated receptor ligands, neuropeptides, endocannabinoids and a selective apoptotic process contribute to a complex regulation of sebocyte-induced immunological reaction in numerous acquired and congenital skin diseases, including hair diseases and atopic dermatitis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk sebaceous gland sebocyte hair follicle developmental biology stem cells immunology inflammation sebaceous gland disease
Megjelenés:	Frontiers in Immunology. - 13 (2022), p. 1029818. -
További szerzők:	Coenye, Tom He, Li Kabashima, Kenji Kobayashi, Tetsuro Niemann, Catherin Nomura, Takashi Oláh Attila (1984-) (élettanász) Picardo, Mauro Quist, Sven R. Sasano, Hironobu Schneider, Marlon R. Töröcsik Dániel (1979-) (bőrgyógyász) Wong, Sunny Y.
Pályázati támogatás:	134235 OTKA 132296 OTKA Bolyai János Kutatási Ösztöndíj MTA ÚNKP-22-5-DE-427 Egyéb NIH R01AR065409 Egyéb NIH R01AR080654 Egyéb TLC-21-161-01-TLC Egyéb 20H03705 Egyéb 20K21534 Egyéb JP21gm6510005 Egyéb LEO Foundation Grant Egyéb Takeda Science Foundation Egyéb 73111208 Egyéb
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