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001-es BibID:	BIBFORM070475
Első szerző:	Oláh Attila (élettanász)
Cím:	Echinacea purpurea-derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema / Oláh Attila, Szabó-Papp Judit, Soeberdt Michael, Knie Ulrich, Dähnhardt-Pfeiffer Stephan, Abels Christoph, Bíró Tamás
Dátum:	2017
ISSN:	0923-1811 1873-569X
Megjegyzések:	Background: Atopic eczema (AE) is a chronic inflammatory and pruritic skin disease. There is still anunmet need for topical anti-inflammatory and anti-pruritic substances exhibiting an excellent safetyprofile. The endocannabinoid system is known to regulate various aspects of cutaneous barrier andimmune functions, thus targeting it may be a valid approach for alleviating the symptoms of AE.Objective: To assess the putative efficacy of Echinacea purpurea-derived alkylamides (Ec. extract)activating cannabinoid (CB)-2 receptors in exerting anti-inflammatory effects and alleviating symptomsof AE.Methods: In vitro anti-inflammatory efficiency was investigated by monitoring the effects of Ec. extract onpoly-(I:C)-induced pro-inflammatory cytokine expression (Q-PCR) and release (ELISA) of HaCaTkeratinocytes. Irritancy and sensitization potential (assessed by Human Repeat Insult Patch Test;Clinical trial 1); clinical efficiency in alleviating symptoms of AE (Clinical trial 2) as well as effects onhuman skin structure and lipid content (Clinical trial 3 followed by transmission electron microscopy andHPTLC) were investigated in randomized double blind clinical trials.Results: Ec. extract significantly reduced mRNA expression as well as release of poly-(I:C)-induced proinflammatorycytokines (IL-6 and IL-8) in keratinocytes. Thus, not surprisingly, the well-tolerated(Clinical trial 1) Ec. extract-based cream reduced local SCORAD statistically significantly, not onlycompared to baseline, but also compared to the comparator (Clinical trial 2). Of great importance, besidesthe in vitro anti-inflammatory effects, administration of the Ec. extract-based cream also resulted insignificantly higher levels of overall epidermal lipids, ceramide EOS (v-esterified fatty acid + sphingosinesphingoid base), and cholesterol at Day 15 compared to baseline as well as significantly greater numbersof intercellular lipid lamellae in the intercellular space (Clinical trial 3).Conclusion: The investigated Ec. extract shows great potential in alleviating cutaneous symptoms of AE,and by exerting remarkable anti-inflammatory actions and restoring the epidermal lipid barrier, it will bevery likely a well-tolerated, powerful novel ingredient for the adjuvant therapy of AE.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Echinacea purpurea Atopic eczema Endocannabinoid system Inflammation Skin barrier
Megjelenés:	Journal Of Dermatological Science 88 : 1 (2017), p. 67-77. -
További szerzők:	Papp Judit (élettanász) Soeberdt, Michael Knie, Ulrich Dähnhardt-Pfeiffer, Stephan Abels, Christoph Bíró Tamás (1968-) (élettanász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM078907
035-os BibID:	(WoS)000373072800058
Első szerző:	Soeberdt, Michael
Cím:	The lipophilic Echinacea purpurea root extract exhibit anti-inflammatory and anti-pruritic properties in vitro and in vivo / M. Soeberdt, A. Olah, U. Knie, T. Biro, S. Dähnhardt-Pfeiffer, C. Abels
Dátum:	2016
Megjegyzések:	Echinacea purpurea extracts (purple coneflower) are known to have immunemodulatory effects. Several alkamides, as the major lipophilic constituents, bind to cannabinoid receptors 1 and 2. Since the endocannabinoid system is of importance in inflammatory skin diseases, anti-inflammatory activity of alkamides was investigated. Therefore the new lipophilic root extract of Echinacea purpurea was tested in cultured human keratinocytes. A significant (P < 0.05) reduction of lipoteichoic acid-induced mRNA expression of IL-1a, IL-1b, and IL-6 was observed. Moreover, the mixture was also able to reduce expression of IL-8 and showed significant anti-inflammatory effects in vitro. The overall impact of the new developed water-in-oil (W/O) emulsion containing the new lipophilic root extract of Echinacea purpurea was investigated in different clinical studies. Long-term efficacy and safety of the Echinacea purpurea root extract (W/O) emulsion was evaluated in a 3 month half-side trial against comparator (30.2 15.9 years; n = 60). The emulsions were applied at least twice daily on two comparable and contralateral located skin areas on the crooks of arms, hollow of the knees, on the trunk, on the wrist or on the shin with slight lesions of atopic dermatitis. Erythema reduced significantly after 1, 2 and 3 months after application of Echinacea purpurea root extract (W/O) emulsion, as well as comparator. Interestingly, Echinacea purpurea root extract (W/O) emulsion is superior after prolonged application, indicated by a significant difference to comparator after 2 and 3 months. A significant reduction of pruritus could be measured after 1, 2 and 3 months. Furthermore Echinacea purpurea root extract (W/O) emulsion was significant superior compared to comparator after 2 months and nearly significant after 3 months. The same was observed for the local SCORAD. A significant reduction could be measured after 1, 2 and 3 months. Furthermore Echinacea purpurea root extract (W/O) emulsion was significant superior compared to comparator after 3 months. To gain further insight in underlying mechanisms, electron microscope analyses of the skin barrier as well as the lipid analysis by HPTLC will be performed and data will be presented. In summary, application of an Echinacea purpurea root extract (W/O) emulsion reduced significantly the local SCORAD, erythema and pruritus without irritation, very likely by improved functions of the epidermal barrier.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk Echinacea purpurea inflammation pruritus
Megjelenés:	Experimental Dermatology. - 25 : 3 (2016), p. E10. -
További szerzők:	Oláh Attila (1984-) (élettanász) Knie, Ulrich Bíró Tamás (1968-) (élettanász) (absztraktok) Dähnhardt-Pfeiffer, Stephan Abels, Christoph
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM071184
035-os BibID:	(WOS)000380028800260
Első szerző:	Soeberdt, Michael
Cím:	Anti-inflammatory and anti-pruritic properties of a lipophilic Echinacea purpurea root extract / M. Soeberdt, A. Oláh, U. Knie, S. Dähnhardt-Pfeiffer, T. Bíró, C. Abels
Dátum:	2016
ISSN:	0022-202X
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Journal of Investigative Dermatology. - 136 : 5 Suppl. 1 (2016), p. S46. -
További szerzők:	Oláh Attila (1984-) (élettanász) Knie, Ulrich Dähnhardt-Pfeiffer, Stephan Bíró Tamás (1968-) (élettanász) (absztraktok) Abels, Christoph
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM071176
Első szerző:	Soeberdt, Michael
Cím:	Anti-inflammatory activity of alkylamides from Echinacea purpurea in keratinocytes in vitro and in mouse models of inflammatory skin diseases / M. Soeberdt, A. Oláh, U. Knie, D. Metze, T. Biro, C. Abels
Dátum:	2014
ISSN:	0022-202X
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:	Journal of Investigative Dermatology. - 133 : Suppl. 1. (2014), p. S14. -
További szerzők:	Oláh Attila (1984-) (élettanász) Knie, Ulrich Metze, Dieter Bíró Tamás (1968-) (élettanász) (absztraktok) Abels, Christoph
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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