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001-es BibID:	BIBFORM104602
035-os BibID:	(Scopus)85141858760 (WOS)000894561800002
Első szerző:	Bácsi Attila (immunológus)
Cím:	Whole blood transcriptome characterization of young female triathlon athletes following an endurance exercise : a pilot study / Bácsi Attila, Penyige András, Becs Gergely, Benkő Szilvia, Kovács Elek Gergő, Jenei Csaba, Pócsi István, Balla József, Csernoch László, Balatoni Ildikó
Dátum:	2022
ISSN:	1094-8341
Megjegyzések:	The vast majority of studies focusing on the effects of endurance exercise on hematological parameters and leukocyte gene expression were performed in adult men, so our aim was to investigate these changes in young females. Four young (age 15.3 ? 1.3 years) elite female athletes completed an exercise session, in which they accomplished the cycling and running disciplines of a junior triathlon race. Blood samples were taken immediately before the exercise, right after the exercise, and then 1, 2, and 7 days later. Analysis of cell counts and routine biochemical parameters was complemented by RNA sequencing (RNA-seq) to whole blood samples. The applied exercise load did not trigger remarkable changes in either cardiovascular or biochemical parameters; however, it caused a significant increase in the percentage of neutrophils and a significant reduction in the ratio of lymphocytes immediately after exercise. Furthermore, endurance exercise induced a characteristic gene expression pattern change in the blood transcriptome. Gene set enrichment analysis (GSEA) using the Reactome database revealed that the expression of genes involved in immune processes and neutrophil granulocyte activation was upregulated, while the expression of genes important in translation and rRNA metabolism was downregulated. Comparison of a set of immune cell gene signatures (ImSig) and our transcriptomic data identified 15 overlapping genes related to T cell functions, and involved in podosome formation and adhesion to the vessel wall. Our results suggest that RNA-seq to whole blood together with ImSig analysis are useful tools for investigation of systemic responses to endurance exercise.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk ImSig RNA sequencing endurance exercise whole blood transcriptome young female athletes
Megjelenés:	Physiological Genomics. - 54 : 11 (2022), p. 457-469. -
További szerzők:	Penyige András (1954-) (molekuláris genetikus) Becs Gergely Benkő Szilvia (1973-) (molekuláris biológus) Kovács Elek Gergő Jenei Csaba (1976-) (kardiológus) Pócsi István (1961-) (vegyész) Balla József (1959-) (belgyógyász, nephrológus) Csernoch László (1961-) (élettanász) Balatoni Ildikó (1970-) (orvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00062 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM110682
035-os BibID:	(cikkazonosító)1085818 (Scopus)85159827903 (WoS)000977904100001
Első szerző:	Ráduly Zsolt (gyógyszerész)
Cím:	New perspectives in application of kidney biomarkers in mycotoxin induced nephrotoxicity, with a particular focus on domestic pigs / Zsolt Ráduly, András Szabó, Miklós Mézes, Ildikó Balatoni, Robert G. Price, Mark E. Dockrell, István Pócsi, László Csernoch
Dátum:	2023
ISSN:	1664-302X
Megjegyzések:	The gradual spread of Aspergilli worldwide is adding to the global shortage of food and is affecting its safe consumption. Aspergillus -derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. Although the kidney functions as the major excretory system in mammals, monitoring and screening for mycotoxin induced nephrotoxicity is only now a developmental area in the field of livestock feed toxicology. Currently the assessment of individual exposure to mycotoxins in man and animals is usually based on the analysis of toxin and/or metabolite contamination in the blood or urine. However, this requires selective and sensitive analytical methods (e.g., HPLC-MS/MS), which are time consuming and expensive. The toxicokinetic of mycotoxin metabolites is becoming better understood. Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease.Beta 2 -microglobulin (beta 2 -MG) and N -acetyl-β-D-glucosaminidase (NAG) are the dominant biomarkers employed routinely in environmental toxicology research, while kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are also emerging as effective markers to identify mycotoxin induced nephropathy. Pigs are exposed to mycotoxins due to their cereal-based diet and are particularly susceptible to Aspergillus mycotoxins. In addition to commonly used diagnostic markers for nephrotoxicity including plasma creatinine, NAG, KIM-1 and NGAL can be used in pigs. In this review, the currently available techniques are summarized, which are used for screening mycotoxin induced nephrotoxicity in farm animals. Possible approaches are considered, which could be used to detect mycotoxin induced nephropathy.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk nephrotoxicity KIM-1 kidney biomarkers mycotoxins animal toxicity NAG NGAL biomarkers mycotoxin induced nephrotoxicity
Megjelenés:	Frontiers in Microbiology. - 14 (2023), p. 1085818. -
További szerzők:	Szabó András Mézes Miklós Balatoni Ildikó (1970-) (orvos) Price, Robert G. Dockrell, Mark E. C. Pócsi István (1961-) (vegyész) Csernoch László (1961-) (élettanász)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00062 GINOP TKP2021-EGA-18 NKFIH RRF-2.3.1-21-2022-00007 Egyéb 2018-1.2.1-NKP-2018-00002 Egyéb
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