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001-es BibID:BIBFORM009720
Első szerző:Piros Sándor (villamosmérnök, mechatronikai mérnök)
Cím:Possible physical mechanisms of tRNA pre-selection in the cytoplasm of Escherichia coli bacteria / Sándor J. Piros, Ghaleb A. Husseini
Dátum:2010
Megjegyzések:In a previous publication, we used kinetic models to simulate the physical movement ofthe transfer RNA (tRNA) in the cytoplasm of Escherichia coli and concluded that tRNA molecules are not able to approach the ribosome by random Brownian motion at a sufficient rate for protein synthesis. In this paper, we propose three mechanisms to explain tRNA pre-selection (to distinguish it from initial selection, we refer to it in this article as "pre-selection") in prokaryotes. The first hypothesis is that the ribosome stores tRNA molecules inside its structure and aids in the pre-selection process. Because no previous reports in literature support such a pre-selection process, we believe that this hypothesis is unlikely. The second hypothesis suggests distant signaling between the ribosome and the cognate-transfer RNA (ctRNA) that allows the correct ctRNA to approach the ribosome and bind to the "A site." Again, no experimental proofofa signaling mechanism between the ribosome and ctRNA exists when they are distant from each other, which renders this hypothesis invalid. Third, we hypothesize that the messenger RNA (mRNA) could act as a "comb" which is able to filter out the consecutive tRNAs from the cytoplasm, thus allowing the correct ctRNA to reach the "A site" in the ribosome. Although the functions of tRNAs, how they are assembled, and how they get charged by amino acids are widely studied and well understood, few articles report on the mechanism by which tRNAs are pre-selected and how they reach the site ofamino-acid assembly, the ribosome. This article suggests several mechanisms to explain this pre-selection process.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
tRNA
Escherichia coli Bacteria
Megjelenés:Advanced Science Letters. - 3 : 1 (2010), p. 37-42. -
További szerzők:Husseini, Ghaleb A.
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001-es BibID:BIBFORM009718
Első szerző:Piros Sándor (villamosmérnök, mechatronikai mérnök)
Cím:Preliminary modeling of transfer RNA kinetics in the cytoplasm of Escherichia coli bacteria / Sándor J. Piros, Ghaleb A. Husseini
Dátum:2010
ISSN:1936-6612
Megjegyzések:Transfer RNAs (tRNAs) can recognize a specific amino acid from a possible pool of 20. Theyare able to transport these protein building-blocks to the ribosome, the site where amino acids assemble into protein chains. Accurate and rapid selection of tRNAs bythe ribosome is critical for cell survival. The aim of this paper is to develop a preliminaryand simple model of tRNA molecular movement in the bacterial (Escherichia coli-E. coli) cytoplasm. We examine the spatial movement/placement of aminoacylated tRNAs in the cytoplasm-viewed from the perspective of that particular aminoacylated tRNA. To achieve this goal, a kinetic model of the interaction between messenger RNA, ribosome, and RNA molecules is developed. The purpose of the simulation is to examine the conditions necessaryf or the tRNA to deliver a particular amino acid to the ribosome within a biological timeframe. Simulation results show that it is unlikelythat tRNAs are able to reach the "A site" of the ribosome byr andom movement.
Tárgyszavak:Műszaki tudományok Anyagtudományok és technológiák idegen nyelvű folyóiratközlemény külföldi lapban
Cytoplasm
Kinetic model
Megjelenés:Advanced Science Letters. - 3 : 1 (2010), p. 28-36. -
További szerzők:Husseini, Ghaleb A.
Internet cím:elektronikus változat
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