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001-es BibID:BIBFORM086813
035-os BibID:(Scopus)85087398268 (cikkazonosító)4833 (WOS)000550348400001
Első szerző:Ádány Róza (megelőző orvostan és népegészségtan szakorvos)
Cím:Prevalence of Insulin Resistance in the Hungarian General and Roma Populations as Defined by Using Data Generated in a Complex Health (Interview and Examination) Survey / Róza Ádány, Péter Pikó, Szilvia Fiatal, Zsigmond Kósa, János Sándor, Éva Bíró, Karolina Kósa, György Paragh, Éva Bácsné Bába, Ilona Veres-Balajti, Klára Bíró, Orsolya Varga, Margit Balázs
Dátum:2020
ISSN:1661-7827 1660-4601
Megjegyzések:Data mainly from one-off surveys clearly show that the health of Roma, the largest ethnic minority of Europe, is much worse than that of the general population. However, results from comprehensive exploratory studies are missing. The aim of our study was to create a complex database for comparative and association studies to better understand the background of the very unfavourable health of Roma, especially the high burden of cardiometabolic diseases. A three-pillar (questionnaire-based, physical and laboratory examinations) health survey was carried out on randomly selected samples of the Hungarian general (HG, n = 417) and Roma (HR, n = 415) populations, and a database consisting of more than half a million datapoints was created. Using selected data, the prevalence rates of metabolic syndrome (MetS) and of its components were determined, and to estimate the risk of insulin resistance (IR), surrogate measures (the homeostasis model assessment of insulin resistance index, quantitative insulin sensitivity check index, McAuley and TyG indices and the TG/HDL-C ratio) were calculated. Receiver operating characteristic curve analysis and Youden's method were used to define the optimal cut-off values of each IR index. The prevalence of MetS was very high in both study populations (HG: 39.8%, HR: 44.0%) with no statistically significant difference between the two groups in females or males. The prevalence of MetS showed a very marked increase in the HR 35?49 years age group. Among surrogate measures, the TyG index showed the greatest power for predicting IR/MetS at a cut-off value of 4.69 (77% sensitivity, 84% specificity) and indicated a 42.3% (HG) and 40.5% (HR) prevalence of IR. The prevalence of MetS and IR is almost equally very unfavourable in both groups; thus, the factors underlying the high premature mortality burden of Roma should be further clarified by investigating the full spectrum of risk factors available in the database, with a special focus on the access of Roma people to preventive and curative health services.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Roma population
health survey
metabolic syndrome
insulin resistance
cut-off values for surrogate indices
HOMA-IR
QUICKI
McAuley index
TG/HDL-C ratio
TyG index
Megjelenés:International Journal of Environmental Research and Public Health. - 17 : 4833 (2020), p. 1-22. -
További szerzők:Pikó Péter (1987-) (biológus) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Bíró Éva (1980-) (megelőző orvostan és népegészségtan szakorvos, egészségfejlesztő) Kósa Karolina (1962-) (népegészségügyi szakember) Paragh György (1953-) (belgyógyász) Bácsné Bába Éva (1968-) (bölcsésztanár, szakközgazda) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Bíró Klára (1970-) (egészségügyi menedzsment) Varga Orsolya (1977-) (orvos, jogász) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
MTA11010
Egyéb
TK2016-78
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM092553
035-os BibID:(cikkazonosító)3206 (WOS)000639196000001 (Scopus)85102693631
Első szerző:Merzah, Mohammed
Cím:Roma Socioeconomic Status Has a Higher Impact on Smoking Behaviour than Genetic Susceptibility / Mohammed Merzah, Zsigmond Kósa, János Sándor, Shewaye Natae, Péter Pikó, Róza Ádány, Szilvia Fiatal
Dátum:2021
ISSN:1661-7827 1660-4601
Megjegyzések:It is a matter of speculation whether the high prevalence of smoking among Hungarian Roma (HR) is related to genetic, gene-environmental interactions or cultural factors. Our aim is to compare the genetic susceptibility and possible effects of determinants associated with smoking behaviours in the Hungarian general (HG) and Roma populations. A complex health survey including three pillars (questionnaire, physical and laboratory examinations) was carried out (NHG = 412 and NHR = 402). Risk allele frequencies of ten single-nucleotide polymorphisms (SNPs) were compared, and their combined effect was estimated by computing unweighted and weighted genetic risk scores (GRS, wGRS). The effects of genetic and environmental factors were investigated in regression analyses after confounders were introduced. Socio-economic status (SES) was calculated based on the Kuppuswamy scale 2019. Risk allele frequencies of only four SNPs were found to be different between populations (p < 0.01). Median values of GRS did not differ, while the wGRS median was slightly higher among Roma individuals (5.2 vs. 4.9; p = 0.02). Roma individuals were more likely to be heavy smokers (ORmales = 2.05, 95% CI [1.47?2.86]; ORfemales = 1.89, 95% CI [1.58? 2.25]. Smokers have lower SES compared to never smokers (SES ?HR = ?0.039, p = 0.023; ?HG = ?0.010, p = 0.049). An inverse relationship was found between SES and smoking behaviours (p < 0.0001) and was found to be a better predictor of smoking behaviours than genetic susceptibility. Our study findings suggest that the high prevalence of smoking behaviours and nicotine-dependence were not revealed to have a genetic susceptibility among HR individuals; therefore, the highest efforts should be focused on targeting SES-related factors in the Roma population. Strengths of the study: This is the first study carried out to investigate and detect the most relevant factors and the possible genetic background of the extremely high prevalence of smoking based in the Roma population. Limitations of the study: No standard instrument has been used to assess the intensity of addiction to nicotine. Because of some participants' unwillingness to define themselves as Roma, the overall HR population was not represented by the sample of this study.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
smoking behaviours
genetic susceptibility
Roma
socioeconomic status
SNP
Megjelenés:International Journal of Environmental Research and Public Health. - 18 : 6 (2021), p. 1-12. -
További szerzők:Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Natae, Shewaye (1982-) (PhD hallgató) Pikó Péter (1987-) (biológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010 and TK2016-78
Egyéb
OTKA 135784
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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