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001-es BibID:BIBFORM085393
035-os BibID:(cikkazonosító)516
Első szerző:Llanaj, Erand (táplálkozási epidemiológus)
Cím:Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma / Erand Llanaj, Péter Pikó, Károly Nagy, Gábor Rácz, Sándor János, Zsigmond Kósa, Szilvia Fiatal, Róza Ádány
Dátum:2020
ISSN:2073-4425 2073-4425
Megjegyzések:Investigations on the impact of genetic factors on the development of obesity have been limited regarding the Roma population?the largest and most vulnerable ethnic minority in Europe of Asian origin. Genetic variants identified from genetic association studies are primarily from European populations. With that in mind, we investigated the applicability of data on selected obesity?related single nucleotide polymorphisms (SNPs), obtained from the Hungarian general (HG) population of European origin, on the Hungarian Roma (HR) population. Twenty preselected SNPs in susceptible alleles, known to be significantly associated with obesity?related phenotypes, were used to estimate the effect of these SNPs on body mass index (BMI) and waist circumference (WC) in HG (N = 1783) and HR (N = 1225) populations. Single SNP associations were tested using linear and logistic regression models, adjusted for known covariates. Out of 20 SNPs, four located in FTO (rs1121980, rs1558902, rs9939609, and rs9941349) showed strong association with BMI and WC as continuous variables in both samples. Computations based on Adult Treatment Panel III (ATPIII) and the International Diabetes Federation's (IDF) European and Asian criteria showed rs9941349 in FTO to be associated only with WC among both populations, and two SNPs rs2867125, rs6548238) in TMEM18 associated with WC only in HG population. A substantial difference (both in direction and effect size) was observed only in the case of rs1801282 in PPAR? on WC as a continuous outcome. Findings suggest that genetic risk scores based on counting SNPs with relatively high effect sizes, defined based on populations with European ancestry, can sufficiently allow estimation of genetic susceptibility for Roma. Further studies are needed to clarify the role of SNP(s) with protective effect(s).
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
obesity
single nucleotide polymorphisms
genetic risk score
susceptibility
Roma
Hungary
Megjelenés:Genes. - 11 (2020), p. 1-13. -
További szerzők:Pikó Péter (1987-) (biológus) Nagy Károly Rácz Gábor Sándor János (1966-) (orvos-epidemiológus) Kósa Zsigmond (1953-) (orvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010
Egyéb
TK2016-78
Egyéb
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