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001-es BibID:BIBFORM109465
035-os BibID:(cikkazonosító)666 (Scopus)85151111518 (WoS)000968394300001
Első szerző:Kurshed, Ali Abbas Mohammad
Cím:Taste Preference-Related Genetic Polymorphisms Modify Alcohol Consumption Behavior of the Hungarian General and Roma Populations / Ali Abbas Mohammad Kurshed, Ferenc Vincze, Péter Pikó, Zsigmond Kósa, János Sándor, Róza Ádány, Judit Diószegi
Dátum:2023
ISSN:2073-4425
Megjegyzések:Harmful alcohol consumption has been considered a major public health issue globally, with the amounts of alcohol drunk being highest in the WHO European Region including Hungary. Alcohol consumption behaviors are complex human traits influenced by environmental factors and numerous genes. Beyond alcohol metabolization and neurotransmitter gene polymorphisms, taste preference-related genetic variants may also mediate alcohol consumption behaviors. Applying the Alcohol Use Disorders Identification Test (AUDIT) we aimed to elucidate the underlying genetic determinants of alcohol consumption patterns considering taste preference gene polymorphisms (TAS1R3 rs307355, TAS2R38 rs713598, TAS2R19 rs10772420 and CA6 rs2274333) in the Hungarian general (HG) and Roma (HR) populations. Alcohol consumption assessment was available for 410 HG and 387 HR individuals with 405 HG and 364 HR DNA samples being obtained for genotyping. No significant associations were found between TAS1R3 rs307355, TAS2R19 rs10772420, and CA6 rs2274333 polymorphisms and alcohol consumption phenotypes. Significant associations were identified between TAS2R38 rs713598 and the number of standard drinks consumed in the HG sample (genotype GG negatively correlated with the number of standard drinks; coef: ?0.136, p = 0.028) and the prevalence of having six or more drinks among Roma (a negative correlation was identified in the recessive model; genotype GG, coef: ?0.170, p = 0.049), although, none of these findings passed the Bonferroni-corrected probability criterion (p > 0.05). Nevertheless, our findings may suggest that alcohol consumption is partially driven by genetically determined taste preferences in our study populations. Further studies are required to strengthen the findings and to understand the drivers of alcohol consumption behavior in more depth.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
alcohol consumption
AUDIT
taste preference
genetic polymorphisms
genetic association
Hungarian population
Roma population
Megjelenés:Genes. - 14 : 3 (2023), p. 1-16. -
További szerzők:Vincze Ferenc (1987-) (táplákozástudományi szakember, epidemiológus) Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Egyéb
Hungarian Academy of Sciences TK2016-78
Egyéb
Eötvös Loránd Research Network (TKCS-2021/32)
Egyéb
135784 National Research, Development, and Innovation Fund of Hungary
Egyéb
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2.

001-es BibID:BIBFORM085393
035-os BibID:(cikkazonosító)516
Első szerző:Llanaj, Erand (táplálkozási epidemiológus)
Cím:Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma / Erand Llanaj, Péter Pikó, Károly Nagy, Gábor Rácz, Sándor János, Zsigmond Kósa, Szilvia Fiatal, Róza Ádány
Dátum:2020
ISSN:2073-4425 2073-4425
Megjegyzések:Investigations on the impact of genetic factors on the development of obesity have been limited regarding the Roma population?the largest and most vulnerable ethnic minority in Europe of Asian origin. Genetic variants identified from genetic association studies are primarily from European populations. With that in mind, we investigated the applicability of data on selected obesity?related single nucleotide polymorphisms (SNPs), obtained from the Hungarian general (HG) population of European origin, on the Hungarian Roma (HR) population. Twenty preselected SNPs in susceptible alleles, known to be significantly associated with obesity?related phenotypes, were used to estimate the effect of these SNPs on body mass index (BMI) and waist circumference (WC) in HG (N = 1783) and HR (N = 1225) populations. Single SNP associations were tested using linear and logistic regression models, adjusted for known covariates. Out of 20 SNPs, four located in FTO (rs1121980, rs1558902, rs9939609, and rs9941349) showed strong association with BMI and WC as continuous variables in both samples. Computations based on Adult Treatment Panel III (ATPIII) and the International Diabetes Federation's (IDF) European and Asian criteria showed rs9941349 in FTO to be associated only with WC among both populations, and two SNPs rs2867125, rs6548238) in TMEM18 associated with WC only in HG population. A substantial difference (both in direction and effect size) was observed only in the case of rs1801282 in PPAR? on WC as a continuous outcome. Findings suggest that genetic risk scores based on counting SNPs with relatively high effect sizes, defined based on populations with European ancestry, can sufficiently allow estimation of genetic susceptibility for Roma. Further studies are needed to clarify the role of SNP(s) with protective effect(s).
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
obesity
single nucleotide polymorphisms
genetic risk score
susceptibility
Roma
Hungary
Megjelenés:Genes. - 11 (2020), p. 1-13. -
További szerzők:Pikó Péter (1987-) (biológus) Nagy Károly Rácz Gábor Sándor János (1966-) (orvos-epidemiológus) Kósa Zsigmond (1953-) (orvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010
Egyéb
TK2016-78
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM111155
035-os BibID:(cikkazonosító)1033 (Scopus)85160375440 (WoS)000997290400001
Első szerző:Nasr, Nayla Mohamed Gomaa
Cím:Comparison of Genetic Susceptibility to Coronary Heart Disease in the Hungarian Populations : Risk Prediction Models for Coronary Heart Disease / Nayla Nasr, Beáta Soltész, János Sándor, Róza Ádány, Szilvia Fiatal
Dátum:2023
ISSN:2073-4425
Megjegyzések:Background and Aim: It was evaluated whether the integration of genetic risk scores (GRS-unweighted, wGRS-weighted) into conventional risk factor (CRF) models for coronary heart disease or acute myocardial infarction (CHD/AMI) could improve the predictive ability of the models. Methods: Subjects and data collected in a previous survey were used to perform regression and ROC curve analyses as well as to examine the role of genetic components. Thirty SNPs were selected, and genotype and phenotype data were available for 558 participants (general: N = 279 and Roma: N = 279). Results: The mean GRS (27.27 ? 3.43 vs. 26.68 ? 3.51, p = 0.046) and wGRS (3.52 ? 0.68 vs. 3.33 ? 0.62, p = 0.001) were significantly higher in the general population. The addition of the wGRS to the CRF model yielded the strongest improvement in discrimination among Roma (from 0.8616 to 0.8674), while the addition of GRS to the CRF model yielded the strongest improvement in discrimination in the general population (from 0.8149 to 0.8160). In addition to that, the Roma individuals were likely to develop CHD/AMI at a younger age than subjects in the general population. Conclusions: The combination of the CRFs and genetic components improved the model's performance and predicted AMI/CHD better than CRFs alone.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
coronary heart disease
developmental models
genetic risk factors
conventional risk factors
Megjelenés:Genes. - 14 : 5 (2023), p. 1-16. -
További szerzők:Soltész Beáta Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Egyéb
Internet cím:Szerző által megadott URL
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM082685
Első szerző:Pikó Péter (biológus)
Cím:The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations / Peter Piko, Szilvia Fiatal, Nardos Abebe Werissa, Bayu Begashaw Bekele, Gabor Racz, Zsigmond Kosa, Janos Sandor, Roza Adany
Dátum:2020
ISSN:2073-4425 2073-4425
Megjegyzések:Background: The triglycerides (TG) to high-density lipoprotein (HDL)-cholesterol (HDLC) ratio (TG/HDL-C) is a well-known predictor for cardiovascular diseases (CVDs) with great heritability background. The cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) gene affect TG/HDL-C ratio. This study aims to explore the association between haplotypes (H) in CETP (based on 5 single nucleotide polymorphisms (SNPs)) and LIPC (based on 6 SNPs) genes and the TG/HDL-C ratio and its components, among Roma and Hungarian general populations. Methods: The prevalence of haplotypes and their effect on HDL-C, TG and TG/HDL-C ratio were calculated in both populations and compared. Results: Ten haplotypes in CETP and 6 in LIPC gene were identified. Three haplotypes in CETP and 3 in LIPC have significant effect on HDL-C level, whereas two in CETP and 3 in LIPC on TG level. The H6 in CETP (? = 0.52, p = 0.015; odds ratio (OR) = 1.87, p = 0.009) and H5 in LIPC (? = 0.56, p < 0.001; OR = 1.51, p = 0.002) have a significant increasing effect on TG/HDL-C ratio and have shown higher prevalence among the Roma, as compared to Hungarian general population. The H2 in the CETP gene has a decreasing effect on the TG/HDL-C ratio (OR = 0.58, p = 0.019) and is significantly less frequent among the Roma. Conclusions: Accumulation of harmful haplotypes in CETP and LIPC genes might have a role in the elevated TG/HDL-C ratio in the Roma population, which contributes to a higher risk in the development of cardiovascular diseases.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
single nucleotide polymorphism
triglyceride
high-density lipoprotein cholesterol
TG/HDL-C ratio
Roma
Hungarian general
CETP
LIPC
haplotype
cardiometabolic risk
Megjelenés:Genes. - 11 : 56 (2020), p. 1-13. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Werissa, Nardos Abebe (1985-) Bekele, Bayu Begashaw (1988-) (PhD hallgató) Rácz Gábor (1982-) (orvos, környezetegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:TÁMOP 4.2.1. B-09/1/KONV-2010-0007
Egyéb
TÁMOP 4.2.2. A-11/1/KONV-2012-0031
Egyéb
GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010
Egyéb
TK2016- 78
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM082148
035-os BibID:(cikkazonosító)942
Első szerző:Werissa, Nardos Abebe
Cím:SNP-Based Genetic Risk Score Modeling Suggests No Increased Genetic Susceptibility of the Roma Population to Type 2 Diabetes Mellitus / Nardos Abebe Werissa, Peter Piko, Szilvia Fiatal, Zsigmond Kosa, Janos Sandor, Roza Adany
Dátum:2019
ISSN:2073-4425
Megjegyzések:Background: In a previous survey, an elevated fasting glucose level (FG) and/or known type 2 diabetes mellitus (T2DM) were significantly more frequent in the Roma population than in the Hungarian general population. We assessed whether the distribution of 16 single nucleotide polymorphisms (SNPs) with unequivocal e ects on the development of T2DM contributes to this higher prevalence. Methods: Genetic risk scores, unweighted (GRS) and weighted (wGRS), were computed and compared between the study populations. Associations between GRSs and FG levels and T2DM status were investigated in separate and combined study populations. Results: The Hungarian general population carried a greater genetic risk for the development of T2DM (GRSGeneral = 15.38 2.70 vs. GRSRoma = 14.80 2.68, p < 0.001; wGRSGeneral = 1.41 0.32 vs. wGRSRoma = 1.36 0.31, p < 0.001). In the combined population models, GRSs and wGRSs showed significant associations with elevated FG (p < 0.001) and T2DM (p < 0.001) after adjusting for ethnicity, age, sex, body mass index (BMI), high-density Lipoprotein Cholesterol (HDL-C), and triglyceride (TG). In these models, the e ect of ethnicity was relatively strong on both outcomes (FG levels: ethnicity = 0.918, p < 0.001; T2DM status: ORethnicity = 2.484, p < 0.001). Conclusions: The higher prevalence of elevated FG and/or T2DM among Roma does not seem to be directly linked to their increased genetic load but rather to their environmental/cultural attributes. Interventions targeting T2DM prevention among Roma should focus on harmful environmental exposures related to their unhealthy lifestyle.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
type 2diabetes
Roma
genetic risk score
targeted intervention
single nucleotide polymorphism
Megjelenés:Genes. - 10 : 11 (2019), p. 1-16. -
További szerzők:Pikó Péter (1987-) (biológus) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:TÁMOP 4.2.1. B-09/1/KONV-2010-0007
Egyéb
TÁMOP 4.2.2. A-11/1/KONV-2012-0031
Egyéb
GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010
Egyéb
TK2016-78
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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