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001-es BibID:	BIBFORM105073
035-os BibID:	(WOS)000382876700016 (Scopus)84991063666 (cikkazonosító)e0161367
Első szerző:	Cnossen, Maryse C.
Cím:	Variation in Structure and Process of Care in Traumatic Brain Injury : provider Profiles of European Neurotrauma Centers Participating in the CENTER-TBI Study / Maryse C. Cnossen, Suzanne Polinder, Hester F. Lingsma, Andrew I. R. Maas, David Menon, Ewout W. Steyerberg, CENTER-TBI Investigators and Participants
Dátum:	2016
ISSN:	1932-6203
Megjegyzések:	Abstract Introduction The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for optimal care for TBI patients. The first step in CER is to map the existing variation. The aim of current study is to quantify variation in general struc tural and process characteristics among centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Methods We designed a set of 11 provider profiling questionnaires with 321 questions about various aspects of TBI care, chosen based on literature and expert opinion. After pilot testing, ques tionnaires were disseminated to 71 centers from 20 countries participating in the CENTER TBI study. Reliability of questionnaires was estimated by calculating a concordance rate among 5% duplicate questions. Results All 71 centers completed the questionnaires. Median concordance rate among duplicate questions was 0.85. The majority of centers were academic hospitals (n = 65, 92%), desig nated as a level I trauma center (n = 48, 68%) and situated in an urban location (n = 70, 99%). The availability of facilities for neuro-trauma care varied across centers; e.g. 40 (57%) had a dedicated neuro-intensive care unit (ICU), 36 (51%) had an in-hospital rehabili tation unit and the organization of the ICU was closed in 64% (n = 45) of the centers. In addi tion, we found wide variation in processes of care, such as the ICU admission policy and intracranial pressure monitoring policy among centers.Conclusion Even among high-volume, specialized neurotrauma centers there is substantial variation in structures and processes of TBI care. This variation provides an opportunity to study effec tiveness of specific aspects of TBI care and to identify best practices with CER approaches.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plos One. - 11 : 8 (2016), p. 1-21. -
További szerzők:	Polinder, Suzanne Lingsma, Hester Maas, Andrew I. R. Menon, David Krishna Steyerberg, Ewout W. Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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001-es BibID:	BIBFORM051384
035-os BibID:	Article ID: e82422
Első szerző:	Mike Andrea (neurológus, Pécs)
Cím:	Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study / Andrea Mike, Erzsebet Strammer, Mihaly Aradi, Gergely Orsi, Gabor Perlaki, Andras Hajnal, Janos Sandor, Miklos Banati, Eniko Illes, Alexander Zaitsev, Robert Herold, Charles R. G. Guttmann, Zsolt Illes
Dátum:	2013
ISSN:	1932-6203
Megjegyzések:	Successful socialization requires the ability of understanding of others' mental states. This ability called as mentalization (Theory of Mind) may become deficient and contribute to everyday life difficulties in multiple sclerosis. We aimed to explore the impact of brain pathology on mentalization performance in multiple sclerosis. Mentalization performance of 49 patients with multiple sclerosis was compared to 24 age- and gender matched healthy controls. T1- and T2-weighted three-dimensional brain MRI images were acquired at 3Tesla from patients with multiple sclerosis and 18 gender- and age matched healthy controls. We assessed overall brain cortical thickness in patients with multiple sclerosis and the scanned healthy controls, and measured the total and regional T1 and T2 white matter lesion volumes in patients with multiple sclerosis. Performances in tests of recognition of mental states and emotions from facial expressions and eye gazes correlated with both total T1-lesion load and regional T1-lesion load of association fiber tracts interconnecting cortical regions related to visual and emotion processing (genu and splenium of corpus callosum, right inferior longitudinal fasciculus, right inferior fronto-occipital fasciculus, uncinate fasciculus). Both of these tests showed correlations with specific cortical areas involved in emotion recognition from facial expressions (right and left fusiform face area, frontal eye filed), processing of emotions (right entorhinal cortex) and socially relevant information (left temporal pole). Thus, both disconnection mechanism due to white matter lesions and cortical thinning of specific brain areas may result in cognitive deficit in multiple sclerosis affecting emotion and mental state processing from facial expressions and contributing to everyday and social life difficulties of these patients.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Plos One [electronic resource]. - 8 : 12 (2013), [10] p. -
További szerzők:	Strammer Erzsébet Aradi Mihály Orsi Gergely Perlaki Gábor Hajnal András Sándor János (1966-) (orvos-epidemiológus) Bánáti Miklós (neurológus, Pécs) Illés Enikő (neurológus, Pécs) Zaitsev, Alexander Herold Róbert Guttmann, Charles R. G. Illés Zsolt (neurológus, Pécs)
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001-es BibID:	BIBFORM100561
035-os BibID:	(cikkazonosító)e0264363 (WOS)000793394000019 (Scopus)85125477470
Első szerző:	Sándor János (orvos-epidemiológus)
Cím:	COVID-19 vaccination coverage in deprived populations living in segregated colonies : a nationwide cross-sectional study in Hungary / Sándor János, Vincze Ferenc, Shrikant Maya Liza, Kőrösi László, Ulicska László, Kósa Karolina, Ádány Róza
Dátum:	2022
ISSN:	1932-6203
Megjegyzések:	The segregated colonies (SCs) in Hungary are populated mainly but not exclusively by Roma. Their health care use is restricted in many respects. It has not been studied yet, whether fair COVID-19 vaccination coverage achieved in Hungary is accompanied with fair effectiveness in SCs. Using census data, the vaccination coverage in SCs and the complementary areas (CAs) in the same settlements of the country was determined. To describe the settlement level differences, the vaccination coverage (until June 30, 2021) in SCs were compared to those in CAs by age, sex, and eligibility for exemption certificate standardized measures. Aggregating settlement level data, the level of geographic discrimination in Hungary was also determined. According to nationwide aggregates, crude vaccination coverage was significantly lower in SCs (40.05%, 95% CI 39.87%-40.23%) than in CAs (65.42%, 95% CI 65.37%-65.46%). The relative standardized vaccination coverage was 0.643 (95% CI 0.639?0.647) in SCs. A total of 437 of the 938 investigated settlements showed significant local vaccination disparities. Hungarian citizens living in SCs, mainly of Roma ethnicity, are a distinct high-risk group. Special intervention adapted to SCs is needed to mitigate inequality in vaccination coverage and further consequences of the pandemic.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plos One. - 17 : 2 (2022), p. e0264363-. -
További szerzők:	Vincze Ferenc (1987-) (táplákozástudományi szakember, epidemiológus) Shrikant, Maya Liza Kőrösi László Ulicska László Kósa Karolina (1962-) (népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	BM/6327-3/2021, FEIF/951/2021-ITM Egyéb
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001-es BibID:	BIBFORM086819
035-os BibID:	(cikkazonosító)e0234547 (WOS)000542759600049 (Scopus)85086691856
Első szerző:	Soltész Beáta
Cím:	The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population / Beáta Soltész, Péter Pikó, János Sándor, Zsigmond Kósa, Róza Ádány, Szilvia Fiatal
Dátum:	2020
ISSN:	1932-6203
Megjegyzések:	Estimating the prevalence of cardiovascular diseases (CVDs) and risk factors among the Roma population, the largest minority in Europe, and investigating the role of genetic or environmental/behavioral risk factors in CVD development are important issues in countries where they are significant minority. This study was designed to estimate the genetic susceptibility of the Hungarian Roma (HR) population to essential hypertension (EH) and compare it to that of the general (HG) population. Twenty EH associated SNPs (in AGT, FMO3, MTHFR-NPPB, NPPA, NPPA-AS1, AGTR1, ADD1, NPR3-C5orf23, NOS3, CACNB2, PLCE1, ATP2B1, GNB3, CYP1A1-ULK3, UMOD and GNAS-EDN3) were genotyped using DNA samples obtained from HR (N = 1176) and HG population (N = 1178) subjects assembled by cross-sectional studies. Allele frequencies and genetic risk scores (unweighted and weighted genetic risk scores (GRS and wGRS, respectively) were calculated for the study groups and compared to examine the joint effects of the SNPs. The susceptibility alleles were more frequent in the HG population, and both GRS and wGRS were found to be higher in the HG population than in the HR population (GRS: 18.98 ? 3.05 vs. 18.25 ? 2.97, p<0.001; wGRS: 1.4 [IQR: 0.93?1.89] vs. 1.52 [IQR: 0.99?2.00], p<0.01). Twenty-seven percent of subjects in the HR population were in the bottom fifth (GRS ? 16) of the risk allele count compared with 21% of those in the HG population. Thirteen percent of people in the HR group were in the top fifth (GRS ? 22) of the GRS compared with 21% of those in the HG population (p<0.001), i.e., the distribution of GRS was found to be left-shifted in the HR population compared to the HG population. The Roma population seems to be genetically less susceptible to EH than the general one. These results support preventive efforts to lower the risk of developing hypertension by encouraging a healthy lifestyle. Helyreigazítás: Plos One. -16 : 7 (2022). -PLoS One. -1932-6203. -1932-6203
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plos One. - 15 : 6 (2020), p. 1-17. -
További szerzők:	Pikó Péter (1987-) (biológus) Sándor János (1966-) (orvos-epidemiológus) Kósa Zsigmond (1953-) (orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:	TÁMOP 4.2.2.A-11/1/KONV-2012-0031 TÁMOP GINOP-2.3.2-15-2016-00005 GINOP
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