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1.

001-es BibID:BIBFORM086813
035-os BibID:(Scopus)85087398268 (cikkazonosító)4833 (WOS)000550348400001
Első szerző:Ádány Róza (megelőző orvostan és népegészségtan szakorvos)
Cím:Prevalence of Insulin Resistance in the Hungarian General and Roma Populations as Defined by Using Data Generated in a Complex Health (Interview and Examination) Survey / Róza Ádány, Péter Pikó, Szilvia Fiatal, Zsigmond Kósa, János Sándor, Éva Bíró, Karolina Kósa, György Paragh, Éva Bácsné Bába, Ilona Veres-Balajti, Klára Bíró, Orsolya Varga, Margit Balázs
Dátum:2020
ISSN:1661-7827 1660-4601
Megjegyzések:Data mainly from one-off surveys clearly show that the health of Roma, the largest ethnic minority of Europe, is much worse than that of the general population. However, results from comprehensive exploratory studies are missing. The aim of our study was to create a complex database for comparative and association studies to better understand the background of the very unfavourable health of Roma, especially the high burden of cardiometabolic diseases. A three-pillar (questionnaire-based, physical and laboratory examinations) health survey was carried out on randomly selected samples of the Hungarian general (HG, n = 417) and Roma (HR, n = 415) populations, and a database consisting of more than half a million datapoints was created. Using selected data, the prevalence rates of metabolic syndrome (MetS) and of its components were determined, and to estimate the risk of insulin resistance (IR), surrogate measures (the homeostasis model assessment of insulin resistance index, quantitative insulin sensitivity check index, McAuley and TyG indices and the TG/HDL-C ratio) were calculated. Receiver operating characteristic curve analysis and Youden's method were used to define the optimal cut-off values of each IR index. The prevalence of MetS was very high in both study populations (HG: 39.8%, HR: 44.0%) with no statistically significant difference between the two groups in females or males. The prevalence of MetS showed a very marked increase in the HR 35?49 years age group. Among surrogate measures, the TyG index showed the greatest power for predicting IR/MetS at a cut-off value of 4.69 (77% sensitivity, 84% specificity) and indicated a 42.3% (HG) and 40.5% (HR) prevalence of IR. The prevalence of MetS and IR is almost equally very unfavourable in both groups; thus, the factors underlying the high premature mortality burden of Roma should be further clarified by investigating the full spectrum of risk factors available in the database, with a special focus on the access of Roma people to preventive and curative health services.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Roma population
health survey
metabolic syndrome
insulin resistance
cut-off values for surrogate indices
HOMA-IR
QUICKI
McAuley index
TG/HDL-C ratio
TyG index
Megjelenés:International Journal of Environmental Research and Public Health. - 17 : 4833 (2020), p. 1-22. -
További szerzők:Pikó Péter (1987-) (biológus) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Bíró Éva (1980-) (megelőző orvostan és népegészségtan szakorvos, egészségfejlesztő) Kósa Karolina (1962-) (népegészségügyi szakember) Paragh György (1953-) (belgyógyász) Bácsné Bába Éva (1968-) (bölcsésztanár, szakközgazda) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Bíró Klára (1970-) (egészségügyi menedzsment) Varga Orsolya (1977-) (orvos, jogász) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
MTA11010
Egyéb
TK2016-78
Egyéb
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2.

001-es BibID:BIBFORM074716
Első szerző:Diószegi Judit (megelőző orvostan és népegészségtan szakorvos)
Cím:Polymorphisms affecting alcohol consumption behaviour in the general Hungarian and Roma populations / J. Diószegi, S. Fiatal, R. Tóth, Á. Moravcsik-Kornyicki, Z. Kósa, J. Sándor, R. Ádány
Dátum:2015
Tárgyszavak:Orvostudományok Egészségtudományok konferenciacikk
Megjelenés:European Journal of Public Health. - 25 : 3 (2015), p. 179-180. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Tóth Réka Moravcsik-Kornyicki Ágota (1986-) (védőnő) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM065965
Első szerző:Diószegi Judit (megelőző orvostan és népegészségtan szakorvos)
Cím:Distribution Characteristics and Combined Effect of Polymorphisms Affecting Alcohol Consumption Behaviour in the Hungarian General and Roma Populations / Judit Diószegi, Szilvia Fiatal, Réka Tóth, Ágota Moravcsik-Kornyicki, Zsigmond Kósa, János Sándor, Martin McKee, Róza Ádány
Dátum:2017
ISSN:0735-0414
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Alcohol
Megjelenés:Alcohol And Alcoholism 52 : 1 (2017), p. 104-111. -
További szerzők:Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Tóth Réka Moravcsik-Kornyicki Ágota (1986-) (védőnő) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) McKee, Martin Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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4.

001-es BibID:BIBFORM105977
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Evaluation of genetic risk related to high fasting glucose level in the Hungarian Roma population / Sz. Fiatal, V. Tomori, P. Pikó, Á. Moravcsik-Kornyicki, B. Soltész, A. Nagy, J. Sándor, R. Ádány
Dátum:2015
ISSN:1101-1262
Megjegyzések:Background Studies showed that health status of Roma population, which represents the largest minority in Central and Eastern Europe, is significantly worse than that of the general population. It is recently pointed out that the prevalence of raised fasting plasma glucose or known type 2 diabetes mellitus (FPG/T2D) were significantly higher in all age groups in the Hungarian Roma (HR) population than in the Hungarian general (HG) population. Our aim was to identify whether a genetic susceptibility contributes to higher FPG/T2D in the HR population. Methods Eighteen single nucleotide polymorphisms were genotyped (Sequenom, MassARRAY platform) in 753 samples from the population of Roma and 1783 samples from the HG population. A genetic risk score (GRS), both unweighted and weighted were constructed for each individual and were compared using two sided t test. Considering the confounding effects of age, gender and BMI on differences in GRS between study populations, analysis of variance models were constructed. Results Although Roma people do not carry more risk alleles than Hungarians counterparts (20.5 2.8 vs. 20.3 2.9, P = 0.19), the average weighted GRS was significantly higher among them comparing to Hungarians (0.51 0.08 vs. 0.49 0.08, p = 4.8X10-4, respectively). This increase causes the distribution of genetic risk to be right-shifted in HR population compared to HG population. Adjustment for confounding factors did not change the inference of mean difference in weighted GRS (P = 5X10-3). Modelling of cumulative GRS suggested that the per-allele effect estimates are slightly also higher in HR than in HG population (OR= 1.1 vs. OR = 1.08, respectively). Conclusions GRS modelling showed that Roma individuals have greater burden of risk alleles compared to HG population. It suggests that there are ethnic specific differences in genetic architecture underlying raised FPG/T2D, which fosters the stratification of the Hungarian population according to T2D disease risk.
Tárgyszavak:Orvostudományok Egészségtudományok konferenciacikk
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 25 : suppl3 (2015), p. 136-137. -
További szerzők:Tomori Valéria Pikó Péter (1987-) (biológus) Moravcsik-Kornyicki Ágota (1986-) (védőnő) Soltész Beáta Nagy A. Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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5.

001-es BibID:BIBFORM105958
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Increased genetic susceptibility of the Hungarian Roma population to venous thrombosis / S. Fiatal, P. Pikó, Z. Kósa, J. Sándor, R. Ádány
Dátum:2017
ISSN:1101-1262
Megjegyzések:Background Studies on Roma populations show the high prevalence of cardiovascular risk factors among them independently from the countries where they live. Sporadic findings suggest that in addition to the environmental/modifiable risk factors genetic susceptibility may also exist behind the high cardiovascular disease morbidity and mortality burden of Roma. Our aim was to define the genetic susceptibility of Hungarian Roma to venous thrombosis by investigating the prevalence of alleles contributing to thrombophilia to a highest extent and compare it to that of the general population. Methods Based on systematic literature review SNPs (N = 48) associated with venous-thrombosis in 32 genes (e.g. F2, F5, F9, F11, F15, FGA, FGB, FGG, CYP4V2, KLKB1, vWF) were selected and analysed in the Hungarian Roma (N = 962) and general (N = 1492) populations. Differences in allele frequencies, as well as genetic risk scores both unweighted (GRS) and weighted (wGRS) were defined for the study groups and compared to estimate the joint effect of SNPs. Results Differences in allele frequencies between the study populations were significant in case of 29 polymorphisms after multiple test correction, and almost all susceptible alleles were more prevalent in the Roma population. Both GRS and wGRS were found significantly higher in Roma than in the general population (GRS: 39.84 5.35 vs. 38.71 5.59, p<0.001; wGRS: 7 1.8 vs. 6.73 1.9, p < 0.01). Only 1.35% of subjects in the Roma population were in the bottom fifth of the wGRS (wGRS 2.5) compared with 2.28% of those in the general population, while 3.62% of the general subjects were in the top fifth of the wGRS (wGRS 9.9) compared with 5.09% of those in the Roma population (p<0.001). Conclusions The Roma population has increased genetic susceptibility to venous thrombosis as it is indicated by higher GRS values in comparison with that for the Hungarian general population.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 27 : suppl3 (2017), p. 31. -
További szerzők:Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM105956
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Fasting plasma glucose related genetic variants show ethnic variation in Hungarian populations / Sz. Fiatal, P. Pikó, Zs. Kósa, J. Sándor, R. Ádány
Dátum:2017
ISSN:1101-1262
Megjegyzések:Background Elevated fasting glucose (FG) level is a risk factor for diabetes. Meta-analyses of European populations' data identified many loci associated with glucose metabolism, but knowledge on other ethnicities is limited. Consequently, the generalizability of results to non-Europeans remains to be clarified. We addressed the question whether the individual effect of established FG related genetic loci are applicable to the Roma considered to have a South Asian origin. Methods Genotyping of 21 SNPs in 19 genes (among them C2CD4B, CDC123, CDKAL1, CDKN2A/B, FADS1, G6PC2, GCKR, GLIS3, SLC2A2, TCF7L2) was performed in Hungarian populations (General: N = 1411; Roma: N = 576). Single SNP associations (direction and magnitude of the effect on FG level) were estimated by regression models using covariates (age, sex). Data obtained on study populations were compared to formerly published European data and to each other. Individuals on antidiabetic treatment were excluded. Results The beta coefficients for SNPs on the sample of general population were found to be almost (except rs5219, rs174550) identical both in direction and magnitude, indicating that the effect is mostly concordant with the results obtained in large scale studies on Europeans. However, among Roma in case of 5 SNPs (rs10946398, rs340874, rs7034200, rs1111875 and rs174550) the effect direction differed in comparison with European data. The rs174550 variant showed difference in effect direction in both populations compared to data on Europeans. Between study populations in case of 5 SNPs (rs10946398, rs340874, rs7034200, rs1111875, rs5219) the association differed in direction, in addition one out of these variants (rs1111875) differed also in magnitude, pointing out the notable ethnic variation among Hungarians. Conclusions Differences observed in effect direction in case of 5 SNPs indicate that data obtained on European populations can be utilised in genetic risk estimation models for Roma with cautions.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 27 : suppl3 (2017), p. 264. -
További szerzők:Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM105951
035-os BibID:(WOS)000506895303139
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Disparities in smoking habits in Hungarian Roma and general populations / S. Fiatal, P. Pikó, Z. Kósa, J. Sándor, R. Ádány
Dátum:2019
ISSN:1101-1262
Megjegyzések:Background: Smoking status, dependence and cessation efforts of the disadvantaged Hungarian Roma living in segregated settlements were compared to those of the general population. Methods: Data were collected through survey. Each study group consists of 500 randomly drawn subjects, and are representative of the adult (18-64) general and Roma population, living in two counties of North-East Hungary. Questions on smoking from the European Health Interview Survey were used with some modifications. Prevalence data were analysed according to age strata (18-29, 30-44 and 45-64 years) by chi2 test, and were compared to data from 2003 and 2014. Results: In Roma the proportion of never smokers is much less compared to the general ones (men:27.27% vs.75%, women:38.6% vs.70.75%, p < 0.05). Less Roma reported never smoking in all age compared to 2014, increasing trend can be found in the general population since 2003. Smoking prevalence is higher in Roma in all ages (72.73% vs.20 83%; 68.42% vs.28.42%; 59.02 vs. 32.26%, p < 0.05, respectively). Interestingly, the prevalence of Roma men smokers is decreasing by age, in the general population the trend is the opposite. Heavy smoker status is the highest in 30-44 age group of both populations. Increasing trend of heavy smoking can be detected in the Roma, but the opposite holds for general population compared to 2014. Half of the Roma smoke within 5 minutes after wakeup (50% vs. 36.92%, p < 0.05), smoke hand-rolled cigarettes (68.91%vs 30.77%, p < 0.05), higher proportion of them tried to quit (34.78% vs. 23.38%, p < 0.05) but smaller proportion of them obtained advise on how to quit (48.53% vs.59.09%, p < 0.05). Initiation starts earlier age among them (men: 15.1 vs.16.6, women: 16.2 vs.18.2, p < 0.05). Conclusions: Regular smoking (especially heavy) is much higher in the Roma and decreasing by age compared to the general in all age-groups. The 30-44 age group of Roma mean are exclusively heavy smokers but half of the Roma show effort to quit.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal Of Public Health. - 29 : Suppl4 (2019), p. 388. -
További szerzők:Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM080279
035-os BibID:(WoS)000470113400008 (Scopus)85065126620
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:Genetic profiling revealed an increased risk of venous thrombosis in the Hungarian Roma population / Szilvia Fiatal, Péter Pikó, Zsigmond Kósa, János Sándor, Róza Ádány
Dátum:2019
ISSN:0049-3848
Megjegyzések:Background Besides modifiable risk factors, genetic susceptibility may also explain the high cardiovascular disease burden of the Roma population. Objectives Aim of this study was to define the genetic susceptibility of Hungarian Roma to venous thrombosis (VT) and comparing it to that of the general population. Methods Fifty-two SNPs associated with VT (in F2, F5, F9, F11, F15, FGA, FGB, FGG, CYP4V2, KLKB1 and vWF) were selected and analyzed in the group of Roma (N?=?962) and general (N?=?1492) subjects collected by cross-sectional studies. Allele frequencies and genetic risk scores (GRS, unweighted and weighted) were computed for the study groups and compared to estimate the joint effects of SNPs. Results The majority of the susceptible alleles were more prevalent in the Roma population, and both GRS and wGRS were found to be significantly higher in Roma than in the general population (GRS: 41.83?±?5.78 vs. 41.04?±?6.04; wGRS: 7.78?±?1.28 vs. 7.46?±?1.33, p?=?.001). Only 2.39% of subjects in the Roma population were in the bottom fifth of the wGRS (wGRS?0.19) compared with 3.62% of those in the general population (p?=?.080); 2.88% of the general subjects were in the top fifth of the wGRS (wGRS?10.02), while 4.26% of the Roma population were (p?=?.066). Conclusion In conclusion, the Roma population seems to have increased genetic susceptibility to VT. This might have important implications in the future in identifying possible new opportunities for targeted prevention and treatment for those subgroups in the populations who are at greater risk for VT development.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Genetic predisposition to disease
Roma
Single nucleotide polymorphisms
Venous thrombosis
Genetic risk scores
Megjelenés:Thrombosis Research. - 179 (2019), p. 37-44. -
További szerzők:Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:TÁMOP 4.2.1. B-09/1/KONV-2010-0007
TÁMOP
TÁMOP 4.2.2.A-11/1/KONV-2012-0031
TÁMOP
GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010
MTA
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM066055
Első szerző:Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background / Szilvia Fiatal, Réka Tóth, Ágota Moravcsik-Kornyicki, Zsigmond Kósa, János Sándor, Martin McKee, Róza Ádány
Dátum:2016
ISSN:1462-2203
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Nicotine & Tobacco Research. - 18 : 12 (2016), p. 2260-2267. -
További szerzők:Tóth Réka Moravcsik-Kornyicki Ágota (1986-) (védőnő) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) McKee, Martin Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM085393
035-os BibID:(cikkazonosító)516
Első szerző:Llanaj, Erand (táplálkozási epidemiológus)
Cím:Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma / Erand Llanaj, Péter Pikó, Károly Nagy, Gábor Rácz, Sándor János, Zsigmond Kósa, Szilvia Fiatal, Róza Ádány
Dátum:2020
ISSN:2073-4425 2073-4425
Megjegyzések:Investigations on the impact of genetic factors on the development of obesity have been limited regarding the Roma population?the largest and most vulnerable ethnic minority in Europe of Asian origin. Genetic variants identified from genetic association studies are primarily from European populations. With that in mind, we investigated the applicability of data on selected obesity?related single nucleotide polymorphisms (SNPs), obtained from the Hungarian general (HG) population of European origin, on the Hungarian Roma (HR) population. Twenty preselected SNPs in susceptible alleles, known to be significantly associated with obesity?related phenotypes, were used to estimate the effect of these SNPs on body mass index (BMI) and waist circumference (WC) in HG (N = 1783) and HR (N = 1225) populations. Single SNP associations were tested using linear and logistic regression models, adjusted for known covariates. Out of 20 SNPs, four located in FTO (rs1121980, rs1558902, rs9939609, and rs9941349) showed strong association with BMI and WC as continuous variables in both samples. Computations based on Adult Treatment Panel III (ATPIII) and the International Diabetes Federation's (IDF) European and Asian criteria showed rs9941349 in FTO to be associated only with WC among both populations, and two SNPs rs2867125, rs6548238) in TMEM18 associated with WC only in HG population. A substantial difference (both in direction and effect size) was observed only in the case of rs1801282 in PPAR? on WC as a continuous outcome. Findings suggest that genetic risk scores based on counting SNPs with relatively high effect sizes, defined based on populations with European ancestry, can sufficiently allow estimation of genetic susceptibility for Roma. Further studies are needed to clarify the role of SNP(s) with protective effect(s).
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
obesity
single nucleotide polymorphisms
genetic risk score
susceptibility
Roma
Hungary
Megjelenés:Genes. - 11 (2020), p. 1-13. -
További szerzők:Pikó Péter (1987-) (biológus) Nagy Károly Rácz Gábor Sándor János (1966-) (orvos-epidemiológus) Kósa Zsigmond (1953-) (orvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010
Egyéb
TK2016-78
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM114683
035-os BibID:(cikkazonosító)13920 (WoS)001073617500001 (Scopus)85172771410
Első szerző:Merzah, Mohammed
Cím:A Transcriptomic Analysis of Smoking-Induced Gene Expression Alterations in Coronary Artery Disease Patients / Mohammed Merzah, Szilárd Póliska, László Balogh, János Sándor, István Szász, Shewaye Natae, Szilvia Fiatal
Dátum:2023
ISSN:1422-0067
Megjegyzések:Abstract: Smoking is a well established risk factor for coronary artery disease (CAD). Despite this, there have been no previous studies investigating the effects of smoking on blood gene expression in CAD patients. This single-centre cross-sectional study was designed with clearly defined inclusion criteria to address this gap. We conducted a high-throughput approach using next generation sequencing analysis with a single-end sequencing protocol and a read length of 75-cycles. Sixty-one patients with a median age of 67 years (range: 28?88 years) were recruited, and only 44 subjects were included for further analyses. Our investigation revealed 120 differentially expressed genes (DEGs) between smokers and nonsmokers, with a fold change (FC) of ?1.5 and a p-value < 0.05. Among these DEGs, 15 were upregulated and 105 were downregulated. Notably, when applying a more stringent adjusted FC ? 2.0, 31 DEGs (5 upregulated, annotated to immune response pathways, and 26 downregulated, involving oxygen and haem binding or activity, with FDR ? 0.03) remained statistically significant at an alpha level of <0.05. Our results illuminate the molecular mechanisms underlying CAD, fortifying existing epidemiological evidence. Of particular interest is the unexplored overexpression of RCAN3, TRAV4, and JCHAIN genes, which may hold promising implications for the involvement of these genes in CAD among smokers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
coronary artery disease
gene expression
smoking
NGS
RNAseq
Megjelenés:International Journal Of Molecular Sciences. - 24 : 18 (2023), p. 1-14. -
További szerzők:Póliska Szilárd (1978-) (biológus) Balogh László (1976-) (kardiológus) Sándor János (1966-) (orvos-epidemiológus) Szász István (1985-) (Ph.D hallgató) Natae, Shewaye (1982-) (PhD hallgató) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM092553
035-os BibID:(cikkazonosító)3206 (WOS)000639196000001 (Scopus)85102693631
Első szerző:Merzah, Mohammed
Cím:Roma Socioeconomic Status Has a Higher Impact on Smoking Behaviour than Genetic Susceptibility / Mohammed Merzah, Zsigmond Kósa, János Sándor, Shewaye Natae, Péter Pikó, Róza Ádány, Szilvia Fiatal
Dátum:2021
ISSN:1661-7827 1660-4601
Megjegyzések:It is a matter of speculation whether the high prevalence of smoking among Hungarian Roma (HR) is related to genetic, gene-environmental interactions or cultural factors. Our aim is to compare the genetic susceptibility and possible effects of determinants associated with smoking behaviours in the Hungarian general (HG) and Roma populations. A complex health survey including three pillars (questionnaire, physical and laboratory examinations) was carried out (NHG = 412 and NHR = 402). Risk allele frequencies of ten single-nucleotide polymorphisms (SNPs) were compared, and their combined effect was estimated by computing unweighted and weighted genetic risk scores (GRS, wGRS). The effects of genetic and environmental factors were investigated in regression analyses after confounders were introduced. Socio-economic status (SES) was calculated based on the Kuppuswamy scale 2019. Risk allele frequencies of only four SNPs were found to be different between populations (p < 0.01). Median values of GRS did not differ, while the wGRS median was slightly higher among Roma individuals (5.2 vs. 4.9; p = 0.02). Roma individuals were more likely to be heavy smokers (ORmales = 2.05, 95% CI [1.47?2.86]; ORfemales = 1.89, 95% CI [1.58? 2.25]. Smokers have lower SES compared to never smokers (SES ?HR = ?0.039, p = 0.023; ?HG = ?0.010, p = 0.049). An inverse relationship was found between SES and smoking behaviours (p < 0.0001) and was found to be a better predictor of smoking behaviours than genetic susceptibility. Our study findings suggest that the high prevalence of smoking behaviours and nicotine-dependence were not revealed to have a genetic susceptibility among HR individuals; therefore, the highest efforts should be focused on targeting SES-related factors in the Roma population. Strengths of the study: This is the first study carried out to investigate and detect the most relevant factors and the possible genetic background of the extremely high prevalence of smoking based in the Roma population. Limitations of the study: No standard instrument has been used to assess the intensity of addiction to nicotine. Because of some participants' unwillingness to define themselves as Roma, the overall HR population was not represented by the sample of this study.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
smoking behaviours
genetic susceptibility
Roma
socioeconomic status
SNP
Megjelenés:International Journal of Environmental Research and Public Health. - 18 : 6 (2021), p. 1-12. -
További szerzők:Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Natae, Shewaye (1982-) (PhD hallgató) Pikó Péter (1987-) (biológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010 and TK2016-78
Egyéb
OTKA 135784
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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