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001-es BibID:	BIBFORM051585
035-os BibID:	PMID:12494871
Első szerző:	Gyöngyi Zoltán
Cím:	Flow cytometric analysis of DMBA-induced early in vivo ras expression / Zoltán Gyongyi, Laszlo Grama, Edit Nádasi, János Sándor, Árpád Németh, Csaba Varga, István Kiss, István Ember
Dátum:	2002
ISSN:	0258-851X
Megjegyzések:	According to recent publications 7,12-dimethylbenz[a]anthracene (DMBA) induces not only mammary cancer but also leukemia in Long-Evans (LE) rats. After treatment with DMBA, trisomy of the chromosome bearing N-ras and mutations in the codon 61 of different ras family genes are frequent. These alterations are already visible within 48 hours. Since there are very few data on ras genes' expression in the early stages of leukemogenesis, in our investigations LE rats were treated with DMBA and the expression of ras genes was measured within two days. DMBA was administered to outbred Long-Evans rats and the fluorescence intensity of the antibody recognizing the ras gene family was measured in femoral bone marrow cells 24 and 48 hours after the treatment. One of the bone marrow cell populations, separated by FSC and SSC, showed elevated ras gene expression at both 24 and 48 hours after the administration of the carcinogen. These results suggest that, besides the specific chromosomal aberrations and gene mutations, elevated ras gene expression could also be the marker of DMBA exposure.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Long-Evans rats DMBA ras gene expression biomarker flow cytometry
Megjelenés:	In Vivo. - 16 : 5 (2002), p. 323-326. -
További szerzők:	Grama László Nádasi Edit Sándor János (1966-) (orvos-epidemiológus) Németh Árpád Varga Csaba Kiss István (Pécs) Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM105441
Első szerző:	Nádasi Edit
Cím:	HER2, P53, FAS, FASL, COX2, PGE2S, EGFR expression in breast cancer and in normal peritumoral breast tissue : potential novel risk biomarkers / Edit Nádasi, János Sándor, Marcella Mottolese, AnnaMaria Cianciulli, Pier Giorgio Natali, István Ember
Dátum:	2004
Megjegyzések:	We analyzed, by using specific antibodies, HER2, p53, Fas and Fas ligand (FasL), expression in 72 breast carcinomas, the corresponding autologous peritumoral tissues (PTT) sampled at 1, 2 and 3 cm from the tumor itself and in 44 benign mammary lesions. Ten breast carcinomas and their autologous 1-cm PTT samples were also analyzed by fluorescent in situ hybridization (FISH) to determine if HER2 gene amplification can be demonstrated in the background of cytoplasmic immunohistochemical HER2 staining. A further 186 stage I-II primary BC and 95 autologous lymph node metastases were analyzed immunohistochemically for cyclooxygenase-2 (COX2), hormone receptors, p53, HER2, Ki67, Fas, FasL and epidermal growth factor receptor (EGFR) expression, to determine their effects on the prognosis of breast cancer patients receiving chemotherapy. The results obtained suggest that HER2 gene amplification often underlies cytoplasmic HER2 staining when analyzed immunohistochemically. Furthermore, breast carcinomas and the closest adjacent uninvolved parenchyma shared an up-regulated FasL phenotype, which is lost in PTT farther from the tumor. Therefore, among the biological parameters investigated, HER2 and FasL expressions seem to represent biomarkers of breast tumorigenesis easily applicable to fine-needle aspirates and potentially useful to detect patients at high risk of breast carcinoma. Moreover, in high-risk breast cancer patients, the immunohistochemical evaluation of COX2, together with PGE2S, p53, Ki67, HER2, Fas and FasL, may be of clinical value in determining 5-year disease-free survival and overall survival for the patient.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk Breast cancer
Megjelenés:	Anticancer Research. - 24 : 5D Suppl (2004), p. 3574. -
További szerzők:	Sándor János (1966-) (orvos-epidemiológus) Mottolese, Marcella Cianciulli, AnnaMaria Natali, Pier Giorgio Ember István
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM051570
Első szerző:	Nádasi Edit
Cím:	Detection of the Leu40Arg variant of the platelet glycoprotein IIb/IIIa receptor in subjects with thrombotic diseases / Edit Nádasi, Judit Bene, Viktória Havasi, Katalin Komlósi, Gábor Talián, György Melegh, Előd Papp, Beáta Gasztonyi, Zoltán Szolnoki, János Sándor, Gyula Mózsik, Kálmán Tóth, Béla Melegh, István Wittmann
Dátum:	2005
ISSN:	0049-3848
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Thrombosis Research. - 116 : 6 (2005), p. 479-482. -
További szerzők:	Bene Judit Havasi Viktória Komlósi Katalin Tálián Gábor Melegh György Papp Előd Gasztonyi Beáta Szolnoki Zoltán Sándor János (1966-) (orvos-epidemiológus) Mózsik Gyula Tóth Kálmán Melegh Béla Wittmann István
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM051574
035-os BibID:	PMID:17352244
Első szerző:	Nádasi Edit
Cím:	Prognostic factors in Hungarian breast cancer patients / Edit Nádasi, Béla Anga, János Sándor, Judit Megyesi, Dezső Kelemen, Marcella Mottolese, Pier Giorgio Natali, Géza Hegedűs, István Arany, István Ember
Dátum:	2007
Megjegyzések:	Breast cancer is the most common cancer among women, with variable outcomes, justifying a continuous search for new parameters to predict accurate prognosis and indicate suitable adjuvant therapy for patients. MATERIALS AND METHODS: Fourty-four stage I-III breast cancer specimens were investigated immunohistochemically for the expression of cyclooxygenase-2 enzyme (COX-2), hormone receptors, tumor suppressor gene p53, oncogene HER2 and proliferation marker Ki-67. Additionally, twelve specimens were also investigated for the presence of the phosphorylated extracellular signal-regulated kinase (pERK). RESULTS: It was demonstrated that expressions of biological markers were related to each other (ER to p53 and Ki-67, COX-2 to ER, PgR, Ki-67 and p53, Ki-67 to p53 and PgR, p53 to PgR). CONCLUSION: Our data indicate that concomitant immunohistochemical evaluation of cyclooxygenase-2, hormone receptors, p53 and Ki-67 may be of clinical value in determining an accurate prognosis.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban breast cancer immunohistochemistry prognostic factors activated extracellular signal-regulated kinase odds ratio
Megjelenés:	Anticancer Research. - 27 : 1A (2007), p. 279-282. -
További szerzők:	Anga Béla Sándor János (1966-) (orvos-epidemiológus) Megyesi Judit Kelemen Dezső Mottolese, Marcella Natali, Pier Giorgio Hegedűs Géza Arany István Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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