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001-es BibID:	BIBFORM051567
035-os BibID:	PMID:10769717
Első szerző:	Kiss István (Pécs)
Cím:	Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes / István Kiss, János Sándor, Gábor Pajkos, Barna Bogner, Géza Hegedűs, István Ember
Dátum:	2000
Megjegyzések:	Chemical carcinogens generally require metabolic activation in order to be able to bind to DNA and contribute to cancer causation. Most of the human metabolizing enzymes are genetically polymorphic, and these polymorphisms may affect the enzyme activity or inducibility. In our present study we investigated the connection between genetic polymorphism of cytochrome P450 1A1, 2E1 (phase I enzymes) and glutathione-S-transferase M1 (a phase II enzyme) and colorectal cancer occurrence in a Hungarian population. The CYP 2E1 c2 allele proved to be in significant association with colorectal cancer (OR: 1.91, 95% CI: 1.05-3.52), the CYP 1A1 Val allele was also overrepresented among colon cancer patients (OR: 1.57, 95% CI: 0.90-2.74), and the frequency of GSTM1 homozygous 0 genotype showed only minor difference (OR: 1.19, 95% CI: 0.75-1.35). Combined analysis of the polymorphisms showed that individuals carrying all the three "high-risk" alleles have a strikingly increased risk for sporadic colorectal cancer (OR: 4.62, 95% CI: 1.23-25.68).
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban metabolizing enzymes CYP 1Al CYP 2E1 GSTM l genetic polymorphisrn cancer susceptibility
Megjelenés:	Anticancer Research. - 20 : 1B (2000), p. 519-522. -
További szerzők:	Sándor János (1966-) (orvos-epidemiológus) Pajkos Gábor Bogner Barna Hegedűs Géza Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM051588
035-os BibID:	PMID:15736440
Első szerző:	Kiss István (Pécs)
Cím:	Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer / István Kiss, Árpád Németh, Barna Bogner, Gábor Pajkos, Zsuzsa Orsós, János Sándor, András Csejtei, Zsolt Faluhelyi, Imre Rodler, István Ember
Dátum:	2004
Megjegyzések:	Glutathione-S-transferases (GSTs) and N-acetyltransferases (NATs) are involved in the metabolism of a wide range of carcinogenic chemicals. Allelic polymorphism of these enzymes is associated with variations in enzyme activity, hence it may affect the concentration of activated carcinogenic chemicals in the body. Previous studies suggest a possible cancer risk-modifying effect of these allelic polymorphisms, but the results are still controversial. We evaluated the effect of GSTM1, GSTT1, GSTP1, NAT1 and NAT2 enzymes on individual susceptibility to colorectal cancer, with particular attention to possible interactions between the studied genotypes. MATERIALS AND METHODS: Five hundred colorectal cancer patients and 500 matched cancer-free controls were included in the study. The allelic polymorphisms of GSTM1, GSTT1 and GSTP1, NAT1 and NAT2 enzymes were determined by PCR-based methods, from peripheral blood leukocytes, and allelic distributions were compared between colorectal cancer patients and controls. RESULTS: The GSTM1 0 allele (OR: 1.48, 95% CI: 1.15-1.92) and rapid acetylator genotypes of NAT2 (OR: 1.52, 95% CI: 1.17-1.98) were associated with an elevated risk No statistically significant correlation between NAT1, GSTT1, GSTP1 genotypes and colorectal cancer was found. Remarkably increased risk was associated with the GSTM1 0 allele--NAT2 rapid acetylator genotype combination (OR: 2.39, 95% CI: 1.75-3.26) and with the GSTM1 0 allele--NAT2 and NAT1 rapid acetylator triple combination (OR: 3.28, 95% CI: 2.06-5.23). Carrying 4 or 5 putative "high-risk" alleles substantially increased the risk of colorectal cancer (OR: 3.69, 95% CI: 2.33-5.86). CONCLUSION: The genotype of certain metabolizing enzymes affects the risk for colorectal cancer. This effect is particularly important when certain allelic combinations are studied. In the near future, individual level risk assessment may be reached by further increasing the number of studied polymorphisms, combining them with traditional epidemiological risk factors.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban colorectal cancer metabolizing enzvmes cancer susceptibility N-acetyltransferase glutathione-S-transferase
Megjelenés:	Anticancer Research. - 24 : 6 (2004), p. 3965-3970. -
További szerzők:	Németh Árpád Bogner Barna Pajkos Gábor Orsós Zsuzsa Sándor János (1966-) (orvos-epidemiológus) Csejtei András Faluhelyi Zsolt Rodler Imre Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM051576
035-os BibID:	PMID:10928094
Első szerző:	Pajkos Gábor
Cím:	The prognostic value of the presence of mutations at the codons 12, 13, 61 of K-ras oncogene in colorectal cancer / Gábor Pajkos, István Kiss, János Sándor, István Ember, Péter Kisházi
Dátum:	2000
Megjegyzések:	The predictive and prognostic value of the c-K-ras mutation is still unequivocal despite extensive and intensive studies. Investigation of the occurrence of mutations in 88 colorectal cancer patients' specimens using the polymerase chain reaction (PCR) is reported: age: 61.9 years (27-80), gender: 48 male, 42 female, Dukes' stages: 43 at B, 35 at C, 10 at D, primary of tumour: 52 colon, 36 rectal adenocarcinoma. Mutation of one of the three ras-codons was detectable in the 54 cases, more frequently at the Dukes' stage C (p < 0.05). The ras-mutation correlated to a more elevated death-rate in the Dukes' B and C stages (p < 0.01). Mean survival time and time to progression were significantly longer at the Dukes' stage B if mutation was not detected (p < 0.01). The genetic alteration occurred significantly more frequently at tumours of the right-side colon, than the left side (p < 0.02) or rectum (p < 0.05). However, in the age group of 41-50 years, it was more significantly identified in the cases of rectal cancer (p < 0.01). At the age of 51-60 years mutations were detected in men at a higher rate (p < 0.05). The mutation of the codon 13 appeared more frequently in the cases of local recurrences (p < 0.05). The occurrence of the ras-oncogene is a sign of an extremely malignant potential of tumour. This fact manifested itself in the time to progression and mean survival time of patients at the same clinical or pathological stage. The higher frequency of genetic alterations at the proximal colon may be the reason for more unfavourable prognosis of the disease localised to this site. Reconstructing the molecular events, the presence of the ras mutation proved to be an important element for prognosis of the disease and should be a basis of potentially individualised therapeutic intervention.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Coltlrectal cancer K-ras oncogene MASA- PCR-method
Megjelenés:	Anticancer Research. - 20 : 3A (2000), p. l695-1702. -
További szerzők:	Kiss István (Pécs) Sándor János (1966-) (orvos-epidemiológus) Ember István Kisházi Péter
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM051624
Első szerző:	Pajkos Gábor
Cím:	A K-ras onkogén 12, 13 és 61 kodonjai mutációjának prognosztikus értéke colorectalis carcinomában / Pajkos Gábor, Kiss István, Sándor János, Ember István, Kisházi Péter
Dátum:	1999
Tárgyszavak:	Orvostudományok Egészségtudományok magyar nyelvű folyóiratközlemény hazai lapban colorectalis carcinoma K-ras onkogén MASA PCR technika
Megjelenés:	Orvosi Hetilap. - 140 : 30 (1999), p. 1673-1679. -
További szerzők:	Kiss István (Pécs) Sándor János (1966-) (orvos-epidemiológus) Ember István Kisházi Péter
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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