CCL

Összesen 7 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM051390
Első szerző:Büki András (általános orvos)
Cím:Geriatric Traumatic Brain Injury in Hungary and Eastern Europe / András Büki, Endre Czeiter, Noémi Kovács, Krisztina Amrein, Erzsébet Ezer, János Sándor, Tamás Dóczi
Dátum:2012
ISSN:2162-4941
Megjegyzések:While the incidence of traumatic brain injury (TBI) is decreasing in the young, active population, injuries are getting more frequent among the elderly; as the geriatric population is in a constant rise and the relative cost of care is particularly high in this group of patients, the economic burden of TBI does not decline. This review is aimed to identify predisposing factors and characteristic features of geriatric brain injury, primarily focusing on the comparison between Eastern and Western European countries. While economically each of these is a high- or middle-income country, the differences in mortality and morbidity, approaches, and policies applied by health care providers are substantial. On the basis of the disappointing outcome results in Eastern Europe, one may conclude that therapeutic guidelines defined on the basis of the "Western experience" should only be applied in conjunction with a systematic reorganization of health care in Eastern Europe.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Brain injury
Trauma
Elderly
Geriatric
Outcome prediction
Glasgow Coma Scale
IMPACT database
Epidemiology
Guideline
Eastern Europe
Hungary
Megjelenés:Current Translational Geriatrics and Experimental Gerontology Reports. - 1 : 3 (2012), p. 159-166. -
További szerzők:Czeiter Endre Kovács Noémi Amrein Krisztina Ezer Erzsébet Sándor János (1966-) (orvos-epidemiológus) Dóczi Tamás
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM051564
Első szerző:Czeiter Endre
Cím:Calpain inhibition reduces axolemmal leakage in traumatic axonal injury / Endre Czeiter, András Büki, Péter Bukovics, Orsolya Farkas, József Pál, Erzsébet Kövesdi, Tamás Dóczi, János Sándor
Dátum:2009
ISSN:1420-3049
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
calpain
MDL-28170
traumatic axonal injury
traumatic brain injury
Megjelenés:Molecules [electronic resource]. - 14 : 12 (2009), p. 5115-5123. -
További szerzők:Büki András (1990-) (általános orvos) Bukovics Péter Farkas Orsolya Pál József Kövesdi Erzsébet Dóczi Tamás Sándor János (1966-) (orvos-epidemiológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM042451
035-os BibID:PMID:22435839
Első szerző:Czeiter Endre
Cím:Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator / Endre Czeiter, Stefania Mondello, Noemi Kovacs, Janos Sandor, Andrea Gabrielli, Kara Schmid, Frank Tortella, Kevin K. W. Wang, Ronald L. Hayes, Pal Barzo, Erzsebet Ezer, Tamas Doczi, Andras Buki
Dátum:2012
ISSN:0897-7151
Megjegyzések:Outcome prediction following severe traumatic brain injury (sTBI) is a widely investigated field of research. A major breakthrough is represented by the IMPACT prognostic calculator based on admission data of more than 8500 patients. A growing body of scientific evidence has shown that clinically meaningful biomarkers, including glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), and αII-spectrin breakdown product (SBDP145), could also contribute to outcome prediction. The present study was initiated to assess whether the addition of biomarkers to the IMPACT prognostic calculator could improve its predictive power. Forty-five sTBI patients (GCS score8) from four different sites were investigated. We utilized the core model of the IMPACT calculator (age, GCS motor score, and reaction of pupils), and measured the level of GFAP, UCH-L1, and SBDP145 in serum and cerebrospinal fluid (CSF). The forecast and actual 6-month outcomes were compared by logistic regression analysis. The results of the core model itself, as well as serum values of GFAP and CSF levels of SBDP145, showed a significant correlation with the 6-month mortality using a univariate analysis. In the core model, the Nagelkerke R(2) value was 0.214. With multivariate analysis we were able to increase this predictive power with one additional biomarker (GFAP in CSF) to R(2)=0.476, while the application of three biomarker levels (GFAP in CSF, GFAP in serum, and SBDP145 in CSF) increased the Nagelkerke R(2) to 0.700. Our preliminary results underline the importance of biomarkers in outcome prediction, and encourage further investigation to expand the predictive power of contemporary outcome calculators and prognostic models in TBI.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
biomarkers
IMPACT calculator
outcome
prognostic models
traumatic brain injury
külföldön készült közlemény
Megjelenés:Journal of Neurotrauma. - 29 : 9 (2012), p. 1770-1778. -
További szerzők:Mondello, Stefania Kovács Noémi Sándor János (1966-) (orvos-epidemiológus) Gabrielli Andrea Schmid, Kara Tortella, Frank Wang, Kevin K. W. Hayes, Ronald L. Barzó Pál Ezer Erzsébet Dóczi Tamás Büki András (1990-) (általános orvos)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM072261
Első szerző:Mondello, Stefania
Cím:Blood-based protein biomarkers for the management of traumatic brain injuries in adults presenting to emergency departments with mild brain injury : a living systematic review and meta-analysis / Stefania Mondello, Abayomi Sorinola, Endre Czeiter, Zoltán Vámos, Krisztina Amrein, Anneliese Synnot, Emma Donoghue, János Sándor, Kevin K. W. Wang, Ramon Diaz-Arrastia, Ewout W. Steyerberg, David K. Menon, Andrew I. R. Maas, Andras Buki
Dátum:2021
ISSN:0897-7151 1557-9042
Megjegyzések:Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision-making beyond current practice standards. We performed a systematic review and meta-analysis to comprehensively and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100B, GFAP, NSE, UCH-L1, Tau and Neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI. Effects of potential confounding factors and differential diagnostic performance of the included markers were explored. Furthermore, appropriateness of study design, analysis, quality and demonstration of clinical utility were assessed. Studies published up to October 2016 were identified through a MEDLINE, EMBASE and CINHAL search. Following screening of the identified articles, 26 were selected as relevant. We found that measurement of S100B can help informed decision making in the emergency department possibly reducing resource use, but there is insufficient evidence that any of the other markers is ready for clinical application. Our work pointed out serious problems in the design, analysis and reporting of many of the studies and identified a substantial heterogeneity and research gaps. These findings emphasize the importance of methodologically rigorous studies focused on a biomarker's intended use and defining standardized, validated and reproducible approaches. The living nature of this systematic review, which will summarize key updated information as it becomes available, can inform and guide future implementation of biomarkers in the clinical arena.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Biomarkers
Traumatic
Brain Injury
Diagnosis
Living Systematic review
Meta analysis
Megjelenés:Journal of Neurotrauma. - 38 : 8 (2021), p. 1086-1106. -
További szerzők:Sorinola, Abayomi Czeiter Endre Vámos Zoltán Amrein Krisztina Synnot, Anneliese Donoghue, Emma Sándor János (1966-) (orvos-epidemiológus) Wang, Kevin K. W. Diaz-Arrastia, Ramon Steyerberg, Ewout W. Menon, David Krishna Maas, Andrew I. R. Buki András
Pályázati támogatás:602150
FP7
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM077719
Első szerző:Sorinola, Abayomi
Cím:Risk Factors of External Ventricular Drain Infection : proposing a Model for Future Studies / Abayomi Sorinola, Andras Buki, Janos Sandor, Endre Czeiter
Dátum:2019
ISSN:1664-2295 1664-2295
Megjegyzések:Background: External ventricular drain (EVD) has a major role in the management and monitoring of intracranial pressure (ICP) and its major complication is EVD infection. The risk factors for EVD infection are still a major topic of controversy, hence the need for further research. Objective: The objective of this review was to identify risk factors that affect the incidence of EVD infection and create a model, which can be used in future studies in order to contribute to elaborations on guideline for EVD. Methods: A PubMed and Google Scholar literature search was performed and data were extracted from studies published from 1966 through 2017. The search of the databases generated 604 articles and 28 articles of these were found to be relevant. A manual search of the 28 relevant papers generated 4 new articles. Of the 32 relevant articles, 20 articles that performed a multivariate analysis of the suspected risk factors of EVD infection and had a positive culture as a mandatory component in diagnosis were selected for data collection and analysis. Results: Because reviewed papers investigated only a few influencing factors, and could not determine convincingly the real risk factors of EVD infection and their real strengths. A total of 15 supposed influencing factors which includes: age, age & sex interactions, coinfection, catheter insertion outside the hospital, catheter type, CSF leakage, CSF sampling frequency, diagnosis, duration of catheterization, ICP > 20 mmHg, irrigation, multiple catheter, neurosurgical operation, reduced CSF glucose at catheter insertion and sex were identified. Conclusion: This review summarizes a set of variables which have to be covered by future clinical epidemiological investigations in order to describe the etiological background of EVD infection.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
external ventricular drain,
EVD infection,
ventricular catheter
ventricular catheter infection,
risk factors
Megjelenés:Frontiers in Neurology. - 10 : 226 (2019), p. 1-8. -
További szerzők:Buki András Sándor János (1966-) (orvos-epidemiológus) Czeiter Endre
Pályázati támogatás:Hungarian Brain Research Program 2.0?Grant No. 2017- 1.2.1-NKP-2017-00002
Egyéb
EFOP-3.6.2.-16-2017-00008
EFOP
Higher Education Institutional Excellence Programme - Grant No. 20765-3/2018/FEKUTSTRAT
Egyéb
GINOP-2.3.2-15-2016-00048
GINOP
GINOP-2.3.3-15-2016-00032
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM070423
Első szerző:Sorinola, Abayomi
Cím:Effectiveness of traumatic brain injury management guideline introduction in Hungary / Abayomi Sorinola, Andras Buki, Janos Sandor, Endre Czeiter
Dátum:2018
ISSN:1019-5149
Megjegyzések:AIm: To describe the impact of the Traumatic Brain Injury management guideline introduction in Hungary.Mater Ial and Methods: Hospital discharge records (HDR) including age, gender, codes of interventions applied, ICD codesof diagnosed disorders of patients admitted between 01/01/2004 and 31/12/2010 with the diagnosis of intracranial injury (S06 byICD10) from every inpatient institution in Hungary were collected from the database of National Health Insurance Fund (NHIF). TheCase Fatality Ratios (CFR) for one week, one month and six months were calculated for the periods before and after the guidelineintroduction. The change of CFRs was applied as indicators for change of clinical quality elicited by the guideline.Results: The centers together at one week, one month and six months had pre-guideline introduction CFRs of 23.4%, 37.7% and47.5% and post-guideline introduction CFRs of 22.1%, 39.1%, and 50.0% respectively. The secondary institutions together at oneweek, one month and six months had pre-guideline introduction CFRs of 21.5%, 34.8% and 46.3% and post-guideline introductionCFRs of 21.9%, 37.0%, and 48.9% respectively. None of the CFRs showed significant change.ConclusIon: The effectiveness of TBI management guideline adaptation in Hungary is poor. Without supportive financing andexternal auditing system, guideline introduction alone cannot achieve standard clinical practice and a reduction in CFR.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Case fatality ratio
Guideline introduction
Guideline
Hungary
Traumatic brain injury
Megjelenés:Turkish Neurosurgery. - 28 : 3 (2018), p. 410-415. -
További szerzők:Buki András Sándor János (1966-) (orvos-epidemiológus) Czeiter Endre
Pályázati támogatás:CENTER-TBI
Egyéb
Hungarian Brain Research Program (KTIA_13_NAP-A-II/8)
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM107353
035-os BibID:(cikkazonosító)2545 (scopus)85130005214 (wos)000793456800026
Első szerző:Thomas, Ilias
Cím:Serum metabolome associated with severity of acute traumatic brain injury / Thomas Ilias, Dickens Alex M., Posti Jussi P., Czeiter Endre, Duberg Daniel, Sinioja Tim, Kråkström Matilda, Retel Helmrich Isabel R. A., Wang Kevin K. W., Maas Andrew I. R., Steyerberg Ewout W., Menon David K., Tenovuo Olli, Hyötyläinen Tuulia, Büki András, Oreŝiĉ Matej, CENTER-TBI Participants and Investigators
Dátum:2022
ISSN:2041-1723
Megjegyzések:Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain. ? 2022. The Author(s).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
traumatic brain injury
Megjelenés:Nature Communications. - 13 : 1 (2022), p. 1-15. -
További szerzők:Dickens, Alex M. Posti, Jussi P. Czeiter Endre Duberg, Daniel Sinioja, Tim Kråkström, Matilda Retel Helmrich, Isabel R. A. Wang, Kevin K. W. Maas, Andrew I. R. Steyerberg, Ewout W. Menon, David Krishna Tenovuo, Olli Hyötyläinen, Tuulia Büki András (1990-) (általános orvos) Orešič, Matej Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.