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001-es BibID:	BIBFORM051588
035-os BibID:	PMID:15736440
Első szerző:	Kiss István (Pécs)
Cím:	Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer / István Kiss, Árpád Németh, Barna Bogner, Gábor Pajkos, Zsuzsa Orsós, János Sándor, András Csejtei, Zsolt Faluhelyi, Imre Rodler, István Ember
Dátum:	2004
Megjegyzések:	Glutathione-S-transferases (GSTs) and N-acetyltransferases (NATs) are involved in the metabolism of a wide range of carcinogenic chemicals. Allelic polymorphism of these enzymes is associated with variations in enzyme activity, hence it may affect the concentration of activated carcinogenic chemicals in the body. Previous studies suggest a possible cancer risk-modifying effect of these allelic polymorphisms, but the results are still controversial. We evaluated the effect of GSTM1, GSTT1, GSTP1, NAT1 and NAT2 enzymes on individual susceptibility to colorectal cancer, with particular attention to possible interactions between the studied genotypes. MATERIALS AND METHODS: Five hundred colorectal cancer patients and 500 matched cancer-free controls were included in the study. The allelic polymorphisms of GSTM1, GSTT1 and GSTP1, NAT1 and NAT2 enzymes were determined by PCR-based methods, from peripheral blood leukocytes, and allelic distributions were compared between colorectal cancer patients and controls. RESULTS: The GSTM1 0 allele (OR: 1.48, 95% CI: 1.15-1.92) and rapid acetylator genotypes of NAT2 (OR: 1.52, 95% CI: 1.17-1.98) were associated with an elevated risk No statistically significant correlation between NAT1, GSTT1, GSTP1 genotypes and colorectal cancer was found. Remarkably increased risk was associated with the GSTM1 0 allele--NAT2 rapid acetylator genotype combination (OR: 2.39, 95% CI: 1.75-3.26) and with the GSTM1 0 allele--NAT2 and NAT1 rapid acetylator triple combination (OR: 3.28, 95% CI: 2.06-5.23). Carrying 4 or 5 putative "high-risk" alleles substantially increased the risk of colorectal cancer (OR: 3.69, 95% CI: 2.33-5.86). CONCLUSION: The genotype of certain metabolizing enzymes affects the risk for colorectal cancer. This effect is particularly important when certain allelic combinations are studied. In the near future, individual level risk assessment may be reached by further increasing the number of studied polymorphisms, combining them with traditional epidemiological risk factors.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban colorectal cancer metabolizing enzvmes cancer susceptibility N-acetyltransferase glutathione-S-transferase
Megjelenés:	Anticancer Research. - 24 : 6 (2004), p. 3965-3970. -
További szerzők:	Németh Árpád Bogner Barna Pajkos Gábor Orsós Zsuzsa Sándor János (1966-) (orvos-epidemiológus) Csejtei András Faluhelyi Zsolt Rodler Imre Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM051679
Első szerző:	Kiss István (Pécs)
Cím:	Daganatok iránti egyéni érzékenységet befolyásoló allélpolimorfizmusok vizsgálata magyarországi roma populációban / Kiss István, Béres Judit, Orsós Zsuzsa, Sándor János, Ember István
Dátum:	2004
Tárgyszavak:	Orvostudományok Egészségtudományok magyar nyelvű folyóiratközlemény hazai lapban
Megjelenés:	Magyar Epidemiológia. - 1 : 1 (2004), p. 69-74. -
További szerzők:	Béres Judit Orsós Zsuzsa Sándor János (1966-) (orvos-epidemiológus) Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM105442
Első szerző:	Orsós Zsuzsa
Cím:	Allelic polymorphisms of metabolizing enzymes in a Hungarian roma population / Zsuzsa Orsós, Judit Béres, János Sándor, István Ember, István Kiss
Dátum:	2004
ISSN:	0250-7005 1791-7530
Megjegyzések:	The Roma population is the largest ethnic minority in Hungary. Their mortality structure differs from the national average. This is partly caused by life-style, environmental and social factors, but genetic factors may also be responsible. Concerning cancer morbidity and mortality, such genetic factors can be polymorphisms of certain metabolizing enzymes, which (based on literature data and on our previous studies) may have an influence on susceptibility to cancer. In the present study, we investigated the allelic polymorphisms of N-acetyltransferase 2 (NAT2), a glutathione-S-transferase M1 (GSTM1), glutathione-S transferase T1 (GSTT1) and cytochrome P450 1A1 (CYP 1A1) metabolizing enzymes in a large group of the Hungarian Romas. The allelic freqencies were compared to the data for the non Roma population. Sample collection was performed in the framework of Roma Project (195 blood samples), genotyping was made from peripheral leukocytes, with PCR based methods (NAT2: rapid and slow acetylators, GST M1 and T1: 0 and + genotypes, CYP 1A1: Ile/Val polymorphism). Our results demonstrated a difference between the allelic distributions of Roma and non Roma populations. Allelic frequencies of GSTM1 (OR: 2.08, 95% CI: 1.45-2.99) and NAT2 (OR: 1.42, 95% CI: 1.00-2.00) were significantly different, while in the case of GSTT1 and CYP 1A1, there was no statistically significant difference. Since both GSTM1 and NAT polymorphisms might have an influence on susceptibility to certain cancers (e.g. colorectal, bladder and lung cancer), the differences found in the allelic distributions may contribute to the mortality differences between the Hungarian Roma and non Roma populations. This hypothesis, however, must be confirmed, e.g. by studying allelic polymorphisms among cancer patients from the Roma population.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk ALLELIC POLYMORPHISMS
Megjelenés:	Anticancer Research. - 24 : 5D Suppl (2004), p. 3587. -
További szerzők:	Béres Judit Sándor János (1966-) (orvos-epidemiológus) Ember István Kiss István
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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