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001-es BibID:BIBFORM105441
Első szerző:Nádasi Edit
Cím:HER2, P53, FAS, FASL, COX2, PGE2S, EGFR expression in breast cancer and in normal peritumoral breast tissue : potential novel risk biomarkers / Edit Nádasi, János Sándor, Marcella Mottolese, AnnaMaria Cianciulli, Pier Giorgio Natali, István Ember
Dátum:2004
Megjegyzések:We analyzed, by using specific antibodies, HER2, p53, Fas and Fas ligand (FasL), expression in 72 breast carcinomas, the corresponding autologous peritumoral tissues (PTT) sampled at 1, 2 and 3 cm from the tumor itself and in 44 benign mammary lesions. Ten breast carcinomas and their autologous 1-cm PTT samples were also analyzed by fluorescent in situ hybridization (FISH) to determine if HER2 gene amplification can be demonstrated in the background of cytoplasmic immunohistochemical HER2 staining. A further 186 stage I-II primary BC and 95 autologous lymph node metastases were analyzed immunohistochemically for cyclooxygenase-2 (COX2), hormone receptors, p53, HER2, Ki67, Fas, FasL and epidermal growth factor receptor (EGFR) expression, to determine their effects on the prognosis of breast cancer patients receiving chemotherapy. The results obtained suggest that HER2 gene amplification often underlies cytoplasmic HER2 staining when analyzed immunohistochemically. Furthermore, breast carcinomas and the closest adjacent uninvolved parenchyma shared an up-regulated FasL phenotype, which is lost in PTT farther from the tumor. Therefore, among the biological parameters investigated, HER2 and FasL expressions seem to represent biomarkers of breast tumorigenesis easily applicable to fine-needle aspirates and potentially useful to detect patients at high risk of breast carcinoma. Moreover, in high-risk breast cancer patients, the immunohistochemical evaluation of COX2, together with PGE2S, p53, Ki67, HER2, Fas and FasL, may be of clinical value in determining 5-year disease-free survival and overall survival for the patient.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
Breast cancer
Megjelenés:Anticancer Research. - 24 : 5D Suppl (2004), p. 3574. -
További szerzők:Sándor János (1966-) (orvos-epidemiológus) Mottolese, Marcella Cianciulli, AnnaMaria Natali, Pier Giorgio Ember István
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001-es BibID:BIBFORM051574
035-os BibID:PMID:17352244
Első szerző:Nádasi Edit
Cím:Prognostic factors in Hungarian breast cancer patients / Edit Nádasi, Béla Anga, János Sándor, Judit Megyesi, Dezső Kelemen, Marcella Mottolese, Pier Giorgio Natali, Géza Hegedűs, István Arany, István Ember
Dátum:2007
Megjegyzések:Breast cancer is the most common cancer among women, with variable outcomes, justifying a continuous search for new parameters to predict accurate prognosis and indicate suitable adjuvant therapy for patients. MATERIALS AND METHODS: Fourty-four stage I-III breast cancer specimens were investigated immunohistochemically for the expression of cyclooxygenase-2 enzyme (COX-2), hormone receptors, tumor suppressor gene p53, oncogene HER2 and proliferation marker Ki-67. Additionally, twelve specimens were also investigated for the presence of the phosphorylated extracellular signal-regulated kinase (pERK). RESULTS: It was demonstrated that expressions of biological markers were related to each other (ER to p53 and Ki-67, COX-2 to ER, PgR, Ki-67 and p53, Ki-67 to p53 and PgR, p53 to PgR). CONCLUSION: Our data indicate that concomitant immunohistochemical evaluation of cyclooxygenase-2, hormone receptors, p53 and Ki-67 may be of clinical value in determining an accurate prognosis.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
breast cancer
immunohistochemistry
prognostic factors
activated extracellular signal-regulated kinase
odds ratio
Megjelenés:Anticancer Research. - 27 : 1A (2007), p. 279-282. -
További szerzők:Anga Béla Sándor János (1966-) (orvos-epidemiológus) Megyesi Judit Kelemen Dezső Mottolese, Marcella Natali, Pier Giorgio Hegedűs Géza Arany István Ember István
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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