CCL

Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM107353
035-os BibID:(cikkazonosító)2545 (scopus)85130005214 (wos)000793456800026
Első szerző:Thomas, Ilias
Cím:Serum metabolome associated with severity of acute traumatic brain injury / Thomas Ilias, Dickens Alex M., Posti Jussi P., Czeiter Endre, Duberg Daniel, Sinioja Tim, Kråkström Matilda, Retel Helmrich Isabel R. A., Wang Kevin K. W., Maas Andrew I. R., Steyerberg Ewout W., Menon David K., Tenovuo Olli, Hyötyläinen Tuulia, Büki András, Oreŝiĉ Matej, CENTER-TBI Participants and Investigators
Dátum:2022
ISSN:2041-1723
Megjegyzések:Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain. ? 2022. The Author(s).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
traumatic brain injury
Megjelenés:Nature Communications. - 13 : 1 (2022), p. 1-15. -
További szerzők:Dickens, Alex M. Posti, Jussi P. Czeiter Endre Duberg, Daniel Sinioja, Tim Kråkström, Matilda Retel Helmrich, Isabel R. A. Wang, Kevin K. W. Maas, Andrew I. R. Steyerberg, Ewout W. Menon, David Krishna Tenovuo, Olli Hyötyläinen, Tuulia Büki András (1990-) (általános orvos) Orešič, Matej Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1