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001-es BibID:BIBFORM107364
035-os BibID:(cikkazonosító)16571 (scopus)85139449944 (wos)000864366600013
Első szerző:Bockhop, Fabian
Cím:Measurement invariance of six language versions of the post-traumatic stress disorder checklist for DSM-5 in civilians after traumatic brain injury / Bockhop Fabian, Zeldovich Marina, Cunitz Katrin, Van Praag Dominique, van der Vlegel Marjolein, Beissbarth Tim; Hagmayer York, von Steinbuechel Nicole, CENTER-TBI Participants and Investigators
Dátum:2022
ISSN:2045-2322
Megjegyzések:Abstract Traumatic brain injury (TBI) is frequently associated with neuropsychiatric impairments such as symptoms of post-traumatic stress disorder (PTSD), which can be screened using self-report instruments such as the Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5). The current study aims to inspect the factorial validity and cross-linguistic equivalence of the PCL-5 in individuals after TBI with differential severity. Data for six language groups (n ? 200; Dutch, English, Finnish, Italian, Norwegian, Spanish) were extracted from the CENTER-TBI study database. Factorial validity of PTSD was evaluated using confirmatory factor analyses (CFA), and compared between four concurrent structural models. A multi-group CFA approach was utilized to investigate the measurement invariance (MI) of the PCL-5 across languages. All structural models showed satisfactory goodness-of-fit with small between-model variation. The original DSM-5 model for PTSD provided solid evidence of MI across the language groups. The current study underlines the validity of the clinical DSM-5 conceptualization of PTSD and demonstrates the comparability of PCL-5 symptom scores between language versions in individuals after TBI. Future studies should apply MI methods to other sociodemographic (e.g., age, gender) and injury-related (e.g., TBI severity) characteristics to improve the monitoring and clinical care of individuals suffering from PTSD symptoms after TBI.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Post-Traumatic Stress Disorder Checklist
traumatic brain injury
Megjelenés:Scientific Reports. - 12 : 1 (2022), p. 1-15. -
További szerzők:Zeldovich, Marina Cunitz, Katrin Van Praag, Dominique van der Vlegel, Marjolein Beissbarth, Tim Hagmayer, York von Steinbuechel, Nicole Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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2.

001-es BibID:BIBFORM107361
035-os BibID:(cikkazonosító)1536 (scopus)85144238216
Első szerző:Howe, Emilie Isager
Cím:Rehabilitation and outcomes after complicated vs uncomplicated mild TBI : results from the CENTER-TBI study / Howe Emilie Isager, Zeldovich Marina, Andelic Nada, von Steinbuechel Nicole, Fure Silje C. R., Borgen Ida M. H., Forslund Marit V., Hellstrm Torgeir, Sberg Helene L., Sveen Unni, Rasmussen Mari, Kleffelgaard Ingerid, Tverdal Cathrine, Helseth Eirik, Lvstad Marianne, Lu Juan, Arango-Lasprilla Juan Carlos, Tenovuo Olli, Azouvi Philippe, Dawes Helen, Roe Cecilie, CENTER-TBI participants and investigators
Dátum:2022
ISSN:1472-6963
Megjegyzések:Background: Despite existing guidelines for managing mild traumatic brain injury (mTBI), evidence-based treat? ments are still scarce and large-scale studies on the provision and impact of specifc rehabilitation services are needed. This study aimed to describe the provision of rehabilitation to patients after complicated and uncomplicated mTBI and investigate factors associated with functional outcome, symptom burden, and TBI-specifc health-related quality of life (HRQOL) up to six months after injury. Methods: Patients (n=1379) with mTBI from the Collaborative European NeuroTrauma Efectiveness Research in TBI (CENTER-TBI) study who reported whether they received rehabilitation services during the frst six months post-injury and who participated in outcome assessments were included. Functional outcome was measured with the Glasgow Outcome Scale ? Extended (GOSE), symptom burden with the Rivermead Post Concussion Symptoms Questionnaire (RPQ), and HRQOL with the Quality of Life after Brain Injury ? Overall Scale (QOLIBRI-OS). We examined whether transi? tion of care (TOC) pathways, receiving rehabilitation services, sociodemographic (incl. geographic), premorbid, and injury-related factors were associated with outcomes using regression models. For easy comparison, we estimated ordinal regression models for all outcomes where the scores were classifed based on quantiles. Results: Overall, 43% of patients with complicated and 20% with uncomplicated mTBI reported receiving rehabili? tation services, primarily in physical and cognitive domains. Patients with complicated mTBI had lower functional level, higher symptom burden, and lower HRQOL compared to uncomplicated mTBI. Rehabilitation services at three or six months and a higher number of TOC were associated with unfavorable outcomes in all models, in addition to pre-morbid psychiatric problems. Being male and having more than 13 years of education was associated with more favorable outcomes. Sustaining major trauma was associated with unfavorable GOSE outcome, whereas living in Southern and Eastern European regions was associated with lower HRQOL
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
traumatic brain injury
Megjelenés:BMC Health Services Research. - 22 : 1 (2022), p. 1-16. -
További szerzők:Zeldovich, Marina Andelic, Nada von Steinbuechel, Nicole Fure, Silje C. R. Borgen, Ida M. H. Forslund, Marit V. Hellstrm, Torgeir Sberg, Helene L. Sveen, Unni Rasmussen, Mari Kleffelgaard, Ingerid Tverdal, Cathrine Helseth, Eirik Lvstad, Marianne Lu, Juan Arango-Lasprilla, Juan Carlos Tenovuo, Olli Azouvi, Philippe Dawes, Helen Roe, Cecilie Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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3.

001-es BibID:BIBFORM116192
035-os BibID:(Scopus)85168315877 (WOS)000993931100001
Első szerző:Mikolić, Ana
Cím:Prognostic Models for Global Functional Outcome and Post-Concussion Symptoms Following Mild Traumatic Brain Injury : A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study / Ana Mikolic, Ewout W. Steyerberg, Suzanne Polinder, Lindsay Wilson, Marina Zeldovich, Nicole von Steinbuechel, Virginia F. J. Newcombe, David K. Menon, Joukjevander Naalt, Hester F. Lingsma, Andrew I. R. Maas, David van Klaveren, CENTER-TBI Participants and Investigators
Dátum:2023
ISSN:0897-7151
Megjegyzések:After mild traumatic brain injury (mTBI), a substantial proportion of individuals do not fully recover on the Glasgow Outcome Scale Extended (GOSE) or experience persistent post-concussion symptoms (PPCS). We aimed to develop prognostic models for the GOSE and PPCS at 6 months after mTBI and to assess the prognostic value of different categories of predictors (clinical variables; questionnaires; computed tomography [CT]; blood biomarkers). From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, we included participants aged 16 or older with Glasgow Coma Score (GCS) 13-15. We used ordinal logistic regression to model the relationship between predictors and the GOSE, and linear regression to model the relationship between predictors and the Rivermead Post-concussion Symptoms Questionnaire (RPQ) total score. First, we studied a pre-specified Core model. Next, we extended the Core model with other clinical and sociodemographic variables available at presentation (Clinical model). The Clinical model was then extended with variables assessed before discharge from hospital: early post-concussion symptoms, CT variables, biomarkers, or all three categories (extended models). In a subset of patients mostly discharged home from the emergency department, the Clinical model was extended with 2-3-week post-concussion and mental health symptoms. Predictors were selected based on Akaike's Information Criterion. Performance of ordinal models was expressed as a concordance index (C) and performance of linear models as proportion of variance explained (R2). Bootstrap validation was used to correct for optimism. We included 2376 mTBI patients with 6-month GOSE and 1605 patients with 6-month RPQ. The Core and Clinical models for GOSE showed moderate discrimination (C = 0.68 95% confidence interval 0.68 to 0.70 and C = 0.70[0.69 to 0.71], respectively) and injury severity was the strongest predictor. The extended models had better discriminative ability (C = 0.71[0.69 to 0.72] with early symptoms; 0.71[0.70 to 0.72] with CT variables or with blood biomarkers; 0.72[0.71 to 0.73] with all three categories). The performance of models for RPQ was modest (R2 = 4% Core; R2 = 9% Clinical), and extensions with early symptoms increased the R2 to 12%. The 2-3-week models had better performance for both outcomes in the subset of participants with these symptoms measured (C = 0.74 [0.71 to 0.78] vs. C = 0.63[0.61 to 0.67] for GOSE; R2 = 37% vs. 6% for RPQ). In conclusion, the models based on variables available before discharge have moderate performance for the prediction of GOSE and poor performance for the prediction of PPCS. Symptoms assessed at 2-3 weeks are required for better predictive ability of both outcomes. The performance of the proposed models should be examined in independent cohorts.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
biomarkers
Glasgow Outcome Scale Extended
mild traumatic brain injury
post-concussion symptoms
predictors
prognostic model
Megjelenés:Journal Of Neurotrauma. - 40 : 15-16 (2023), p. 1651-1670. -
További szerzők:Steyerberg, Ewout W. Polinder, Suzanne Wilson, Lindsay Zeldovich, Marina von Steinbuechel, Nicole Newcombe, Virginia F. J. Menon, David Krishna Naalt, Joukjevander Lingsma, Hester Maas, Andrew I. R. van Klaveren, David Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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4.

001-es BibID:BIBFORM107489
035-os BibID:(Scopus)85071987996 (WOS)000485784000017
Első szerző:Steyerberg, Ewout W.
Cím:Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI : a European prospective, multicentre, longitudinal, cohort study / Ewout W. Steyerberg, Eveline Wiegers, Charlie Sewalt, Andras Buki, Giuseppe Citerio, Véronique De Keyser, Ari Ercole, Kevin Kunzmann, Linda Lanyon, Fiona Lecky, Hester Lingsma, Geoffrey Manley, David Nelson, Wilco Peul, Nino Stocchetti, Nicole von Steinbüchel, Thijs Vande Vyvere, Jan Verheyden, Lindsay Wilson, Andrew I. R. Maas, David K. Menon, CENTER-TBI Participants and Investigators
Dátum:2019
ISSN:1474-4422 1474-4465
Megjegyzések:Background The burden of traumatic brain injury (TBI) poses a large public health and societal problem, but the characteristics of patients and their care pathways in Europe are poorly understood. We aimed to characterise patient case-mix, care pathways, and outcomes of TBI. Methods CENTER-TBI is a Europe-based, observational cohort study, consisting of a core study and a registry. Inclusion criteria for the core study were a clinical diagnosis of TBI, presentation fewer than 24 h after injury, and an indication for CT. Patients were differentiated by care pathway and assigned to the emergency room (ER) stratum (patients who were discharged from an emergency room), admission stratum (patients who were admitted to a hospital ward), or intensive care unit (ICU) stratum (patients who were admitted to the ICU). Neuroimages and biospecimens were stored in repositories and outcome was assessed at 6 months after injury. We used the IMPACT core model for estimating the expected mortality and proportion with unfavourable Glasgow Outcome Scale Extended (GOSE) outcomes in patients with moderate or severe TBI (Glasgow Coma Scale [GCS] score ?12). The core study was registered with ClinicalTrials.gov, number NCT02210221, and with Resource Identification Portal (RRID: SCR_015582). Findings Data from 4509 patients from 18 countries, collected between Dec 9, 2014, and Dec 17, 2017, were analysed in the core study and from 22 782 patients in the registry. In the core study, 848 (19%) patients were in the ER stratum, 1523 (34%) in the admission stratum, and 2138 (47%) in the ICU stratum. In the ICU stratum, 720(36%) patients had mild TBI (GCS score 13?15). Compared with the core cohort, the registry had a higher proportion of patients in the ER (9839 [43%]) and admission (8571 [38%]) strata, with more than 95% of patients classified as having mild TBI. Patients in the core study were older than those in previous studies (median age 50 years [IQR 30?66], 1254 [28%] aged >65 years), 462 (11%) had serious comorbidities, 772 (18%) were taking anticoagulant or antiplatelet medication, and alcohol was contributory in 1054 (25%) TBIs. MRI and blood biomarker measurement enhanced characterisation of injury severity and type. Substantial inter-country differences existed in care pathways and practice. Incomplete recovery at 6 months (GOSE <8) was found in 207 (30%) patients in the ER stratum, 665 (53%) in the admission stratum, and 1547 (84%) in the ICU stratum. Among patients with moderate-to-severe TBI in the ICU stratum, 623 (55%) patients had unfavourable outcome at 6 months (GOSE <5), similar to the proportion predicted by the IMPACT prognostic model (observed to expected ratio 1?06 [95% CI 0?97?1?14]), but mortality was lower than expected (0?70 [0?62?0?76])
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
traumatic brain injury
Megjelenés:Lancet Neurology. - 18 : 10 (2019), p. 923-934. -
További szerzők:Wiegers, Eveline Janine Anna Sewalt, Charlie Aletta Buki András Citerio, Giuseppe Keyser, Véronique de Ercole, Ari Kunzmann, Kevin Lanyon, Linda Lecky, Fiona Lingsma, Hester Manley, Geoffrey T. Nelson, David Peul, Wilco C. Stocchetti, Nino von Steinbuechel, Nicole Vande Vyvere, Thijs Verheyden, Jan Wilson, Lindsay Maas, Andrew I. R. Menon, David Krishna Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM107355
035-os BibID:(scopus)85132842261 (wos)000834619400012
Első szerző:van der Vlegel, Marjolein
Cím:Health care utilization and outcomes in older adults after Traumatic Brain Injury : a CENTER-TBI study / van der Vlegel Marjolein, Mikolic Ana, Lee Hee Quentin, Kaplan Z. L. Rana, Retel Helmrich Isabel R. A., van Veen Ernest, Andelic Nada, Steinbuechel Nicole v., Plass Anne Marie, Zeldovich Marina, Wilson Lindsay, Maas Andrew I. R., Haagsma Juanita A., Polinder Suzanne, CENTER-TBI Participants and Investigators
Dátum:2022
ISSN:0020-1383
Megjegyzések:Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ?65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month out- comes after TBI and their determinants in older adults who sustained a TBI. Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effective- ness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care uti- lization and outcomes were described for patients aged ?65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six- month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with func- tional impairment, lower generic and disease-specific HRQoL and mental health symptoms. Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Traumatic Brain Injury Older adults Outcomes
Health care utilization
Health-related quality of life
Mental health
Megjelenés:Injury-International Journal Of The Care Of The Injured. - 53 : 8 (2022), p. 2774-2782. -
További szerzők:Mikolić, Ana Lee Hee, Quentin Kaplan, Z. L. Rana Retel Helmrich, Isabel R. A. van Veen, Ernest Andelic, Nada von Steinbuechel, Nicole Plass, Anne Marie Zeldovich, Marina Wilson, Lindsay Maas, Andrew I. R. Haagsma, Juanita A. Polinder, Suzanne Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM107433
035-os BibID:(scopus)85087993373 (wos)000548832800001
Első szerző:Voormolen, Daphne C.
Cím:Health-related quality of life after traumatic brain injury : deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom / Voormolen Daphne C., Polinder Suzanne, von Steinbuechel Nicole, Feng Yan, Wilson Lindsay, Oppe Mark, Haagsma Juanita A., CENTER-TBI participants and investigators
Dátum:2020
ISSN:0962-9343
Megjegyzések:Purpose The Quality of Life after Brain Injury overall scale (QOLIBRI-OS) measures health-related quality of life (HRQoL) after traumatic brain injury (TBI). The aim of this study was to derive value sets for the QOLIBRI-OS in three European countries, which will allow calculation of utility scores for TBI health states. Methods A QOLIBRI-OS value set was derived by using discrete choice experiments (DCEs) and visual analogue scales (VAS) in general population samples from the Netherlands, United Kingdom and Italy. A three-stage procedure was used: (1) A selection of health states, covering the entire spectrum of severity, was defned; (2) General population samples performed the health state valuation task using a web-based survey with three VAS questions and an at random selection of sixteen DCEs; (3) DCEs were analysed using a conditional logistic regression and were then anchored on the VAS data. Utility scores for QOLIBRI-OS health states were generated resulting in estimates for all potential health states. Results The questionnaire was completed by 13,623 respondents. The biggest weight increase for all attributes is seen from "slightly" to "not at all satisfed", resulting in the largest impact on HRQoL. "Not at all satisfed with how brain is working" should receive the greatest weight in utility calculations in all three countries. Conclusion By transforming the QOLIBRI-OS into utility scores, we enabled the application in economic evaluations and in summary measures of population health, which may be used to inform decision-makers on the best interventions and strategies for TBI patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Health-related quality of life
Quality of life after brain injury overall scale (QOLIBRI-OS)
Health utilities
Value set
Traumatic brain injury
Megjelenés:Quality Of Life Research. - 29 : 11 (2020), p. 3095-3107. -
További szerzők:Polinder, Suzanne von Steinbuechel, Nicole Feng, Yan Wilson, Lindsay Oppe, Mark Haagsma, Juanita A. Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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Intézményi repozitóriumban (DEA) tárolt változat
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