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001-es BibID:BIBFORM107417
035-os BibID:(scopus)85130632973 (wos)000727129000001
Első szerző:Ceyisakar, Iris E.
Cím:Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences? / Ceyisakar Iris E., Huijben Jilske A., Maas Andrew I. R., Lingsma Hester F., van Leeuwen Nikki, CENTER-TBI participants and investigators
Dátum:2021
ISSN:1541-6933
Megjegyzések:Abstract Background: In traumatic brain injury (TBI), large between-center diferences in treatment and outcome for patients managed in the intensive care unit (ICU) have been shown. The aim of this study is to explore if European neuro trauma centers can be clustered, based on their treatment preference in diferent domains of TBI care in the ICU. Methods: Provider profles of centers participating in the Collaborative European Neurotrauma Efectiveness Research in TBI study were used to assess correlations within and between the predefned domains: intracranial pressure monitoring, coagulation and transfusion, surgery, prophylactic antibiotics, and more general ICU treatment policies. Hierarchical clustering using Ward's minimum variance method was applied to group data with the highest similarity. Heat maps were used to visualize whether hospitals could be grouped to uncover types of hospitals adher ing to certain treatment strategies. Results: Provider profles were available from 66 centers in 20 diferent countries in Europe and Israel. Correlations within most of the predefned domains varied from low to high correlations (mean correlation coefcients 0.2?0.7). Correlations between domains were lower, with mean correlation coefcients of 0.2. Cluster analysis showed that policies could be grouped, but hospitals could not be grouped based on their preference. Conclusions: Although correlations between treatment policies within domains were found, the failure to cluster hospitals indicates that a specifc treatment choice within a domain is not a proxy for other treatment choices within or outside the domain. These results imply that studying the efects of specifc TBI interventions on outcome can be based on between-center variation without being substantially confounded by other treatments. Trial registration: We do not report the results of a health care intervention.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Provider profling
Between-hospital variation
Comparative efectiveness research
Traumatic brain injury
Megjelenés:Neurocritical Care. - 36 : 3 (2021), p. 846-856. -
További szerzők:Huijben, Jilske A. Maas, Andrew I. R. Lingsma, Hester van Leeuwen, Nikki Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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