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001-es BibID:	BIBFORM028037
Első szerző:	Király Róbert (biológus)
Cím:	Protein transamidation by transglutaminase 2 in cells : a disputed Ca2+ -dependent action of a multifunctional protein / Király Róbert, Demény Máté Á., Fésüs László
Dátum:	2011
ISSN:	1742-464X
Megjegyzések:	Transglutaminase 2 (TG2) is the first described cellular member of an enzyme family catalyzing Ca2+-dependent transamidation of proteins. During the last two decades its additional enzymatic (GTP binding and hydrolysis, protein disulfide isomerase, protein kinase) and non-enzymatic (multiple interactions in protein scaffolds) activities, which do not require Ca2+, have been recognized. It became a prevailing view that TG2 is silent as a transamidase, except in extreme stress conditions, in the intracellular environment characterized by low Ca2+ and high GTP concentrations. To counter this presumption a critical review of the experimental evidence supporting the role of this enzymatic activity in cellular processes is provided. It includes the structural basis of TG2 regulation through non-canonical Ca2+ binding sites, mechanisms making it sensitive to low Ca2+ concentrations, techniques developed for the detection of protein transamidation in cells and examples of basic cellular phenomena as well as pathological conditions influenced by this irreversible post-translational protein modification.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekuláris Medicina
Megjelenés:	Febs Journal. - 278 : 24 (2011), p. 4717-4739. -
További szerzők:	Demény Máté Ágoston (1976-) (molekuláris biológus) Fésüs László (1947-) (orvos biokémikus)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Az apoptózis molekuláris mechanizmusa MRTNCT-2006-036032 EGYÉB MRTNCT-2006-035624 EGYÉB LSHB-CT-2007-037730 EGYÉB
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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