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001-es BibID:	BIBFORM057885
Első szerző:	Bodoki Levente (PhD hallgató)
Cím:	Four dermatomyositis-specific autoantibodies-anti-TIF1[gamma], anti-NXP2, anti-SAE and anti-MDA5-in adult and juvenile patients with idiopathic inflammatory myopathies in a Hungarian cohort / Levente Bodoki, Melinda Nagy-Vincze, Zoltán Griger, Zoe Betteridge, Lászlóné Szöllősi, Katalin Dankó
Dátum:	2014
ISSN:	1568-9972
Megjegyzések:	Idiopathic inflammatory myopathies (IIMs) are chronic systemic autoimmune diseases characterised by symmetrical, proximal muscle weakness. Dermatomyositis represents one subset of IIMs, in which skin rashes are present in addition to muscle weakness. Myositis-specific antibodies can only be detected in myositis, and they are directed against specific proteins found in the cytoplasm or in the nucleus of cells. With this case-based article, we introduce the recently detected anti-TIF1?, anti-NXP2, anti-SAE and anti-MDA5 antibodies that form various clinical groups. These antibodies could be detected in patients with dermatomyositis. The myositis-specific autoantibodies of three hundred and thirty-seven Hungarian patients with IIM were detected. Retrospective analysis of the clinical findings has also been introduced by revision of the medical history. We had twelve patients with anti-TIF1? positivity, four patients with anti-NXP2 positivity and four patients with anti-SAE positivity. We did not have any positive anti-MDA5 patients. The most relevant clinical findings were similar to those seen in previously published reports. Eleven of the twelve patients with anti-TIF1? positivity had classical dermatomyositis. Three of the twelve anti-TIF1? patients had cancer during the disease progression. This was two out of four for the anti-NXP2 subgroup and one in four for the anti-SAE subgroup. In two juvenile dermatomyositis cases, typical ulceration was seen in patients with anti-TIF1? positivity. The frequency of pulmonary fibrosis during the disease progression was 2/12, 1/4 and 1/4 in anti-TIF1?, anti-NXP2 and anti-SAE, respectively. Other extra-muscular manifestations, such as arthralgia, dysphagia, dysphonia and dyspnoea, were also detectable. The myositis subgroups determined by these myositis-specific autoantibodies differ from each other in their symptoms, prognosis and therapy responsiveness. Their detection is helpful for the preparation of an adequate treatment, but in daily diagnostic methods, these antibodies cannot be detected. By presenting our anti-TIF1?, anti-NXP2 and anti-SAE cases, we would like to highlight the clinical role of these antibodies.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Autoimmunity Reviews. - 13 : 12 (2014), p. 1211-1219. -
További szerzők:	Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Betteridge, Zoe Szőllősi Lászlóné Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus)
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001-es BibID:	BIBFORM109481
035-os BibID:	(cikkazonosító)103311 (Scopus)85150926379 (WoS)000951636500001
Első szerző:	Mogyoróssy Sándor
Cím:	Novel aspects of muscle involvement in immune-mediated inflammatory arthropathies and connective tissue diseases / Mogyoróssy Sándor, Nagy-Vincze Melinda, Griger Zoltán, Dankó Katalin, Szabó Nóra Anna, Szekanecz Zoltán, Szűcs Gabriella, Szántó Antónia, Bodoki Levente
Dátum:	2023
ISSN:	1568-9972
Megjegyzések:	Myalgia, myopathy and myositis are the most important types of muscle impairment in immune-mediated inflammatory arthropathies and connective tissue diseases. Multiple pathogenetic and histological changes occur in the striated muscles of these patients. Clinically, the most important muscle involvement is the one that causes complaints to the patients. In everyday practice, insidious symptoms present a serious problem for the clinician; in many cases, it is difficult to decide when and how to treat the muscle symptoms that are often present only subclinically. In this work, authors review the international literature on the types of muscle problems in autoimmune diseases. In scleroderma histopathological picture of muscle shows a very heterogeneous picture, necrosis and atrophy are common. In rheumatoid arthritis and systemic lupus erythematosus, myopathy is a much less defined concept, further studies are needed to describe it. According to our view, overlap myositis should be recognized as a separate entity, preferably with distinct histological and serological characteristics. More studies are needed to describe muscle impairment in autoimmune diseases which may help to explore this topic more in depth and be of clinical use.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Myalgia Myopathy Myositis Rheumatoid arthritis Systemic sclerosis Systemic lupus erythematosus
Megjelenés:	Autoimmunity Reviews. - 22 : 5 (2023), p. 1-7. -
További szerzők:	Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Szabó Nóra Anna (1976-) (orvos) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus) Bodoki Levente (1986-) (PhD hallgató)
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