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001-es BibID:BIBFORM058519
Első szerző:Kaarniranta, Kai (szemész szakorvos)
Cím:A novel proteotoxic stress associated mechanism for macular corneal dystrophy / Kai Kaarniranta, Eszter Szalai, Adrian Smedowski, Zoltán Hegyi, Niko Kivinen, Johanna Viiri, Bogumil Wowra, Dariusz Dobrowolski, László Módis Jr., András Berta, Edward Wylegala, Szabolcs Felszeghy
Dátum:2015
ISSN:0213-3911
Megjegyzések:Summary. Macular corneal dystrophy is a rare autosomal recessive eye disease affecting primarily the corneal stroma. Abnormal accumulation of proteoglycan aggregates has been observed intra- and extracellularly in the stromal layer. In addition to the stromal keratocytes and corneal lamellae, deposits are also present in the basal epithelial cells, endothelial cells and Descemet's membrane. Misfolding of proteins has a tendency to gather into aggregating deposits. We studied interaction of molecular chaperones and proteasomal clearance in macular dystrophy human samples and in human corneal HCE-2 epithelial cells. Seven cases of macular corneal dystrophy and four normal corneal buttons collected during corneal transplantation were examined for their expression patterns of heat shock protein 70, ubiquitin protein conjugates and SQSTM1/p62. In response to proteasome inhibition the same proteins were analyzed by western blotting. Slitlamp examination, in vivo confocal cornea microscopy and transmission electron microscopy were used for morphological analyses. Heat shock protein 70, ubiquitin protein conjugates and SQSTM1/p62 were upregulated in both the basal corneal epithelial cells and the stromal keratocytes in macular corneal dystrophy samples that coincided with an increased expression of the same molecules under proteasome inhibition in the HCE-2 cells in vitro. We propose a novel regulatory mechanism that connects the molecular chaperone and proteasomal clearance system in the pathogenesis of macular corneal dystrophy.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Heat shock proteins
Macular corneal dystrophy
Misfolding
Protein aggregation
Ubiquitin/ proteasome pathway
Megjelenés:Histology And Histopathology 30 : 8 (2015), p. 921-930. -
További szerzők:Szalai Eszter (1984-) (orvos) Smedowski, Adrian Hegyi Zoltán (1983-) (molekuláris biológus) Kivinen, Niko Viiri, Johanna Wowra, Bogumil Dobrowolski, Dariusz Módis László (1964-) (szemész szakorvos, kontaktológus) Berta András (1955-) (szemész, gyermekszemész) Wylegala, Edward Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus)
Pályázati támogatás:TÁMOP-4.2.4. A/2-11-1-2012-0001
TÁMOP
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001-es BibID:BIBFORM020319
Első szerző:Módis László (szemész szakorvos, kontaktológus)
Cím:Evaluation of the corneal endothelium in patients with diabetes mellitus type I and II / Módis L. Jr., Szalai E., Kertész K., Kemény-Beke A., Kettesy B., Berta A.
Dátum:2010
ISSN:0213-3911
Megjegyzések:The aim of the present study is to determine corneal physiology and endothelial morphology after proper image analysis technique in type I and II diabetic patients. The HbA1c level and the grade of retinopathy were also recorded and correlated with the endothelial parameters. METHODS: 41 eyes of 21 patients with type I and 59 eyes of 30 patients with type II diabetes mellitus (mean age was 40.97 ± 15.46 and 64.36 ± 10.47 years) were examined and compared to age-matched controls. Endothelial cell density (ECD), mean cell area, coefficient of variation of cell area, central corneal thickness, intraocular pressure, and grade of retinopathy were recorded. RESULTS: There was a statistically significant decreased endothelial cell density in type I disease (2428 ± 219 cell/mm2) in comparison with healthy subjects (2495 ± 191 cell/mm2, P=0.02). The diabetic corneas were thicker than normal (P=0.001). The HbA1c level was inversely correlated with the ECD (r=-0.60; P<0.0001) and correlated with the mean endothelial cell area (r=0.60, P<0.0001). Significant correlation was observed between the endothelial morphology and grade of diabetic retinopathy (r=-0.40, ECD; r=0.38, mean cell area; P=0.01 for both). In type II diabetes mellitus no significant difference was found in the evaluated values. CONCLUSIONS: The present study disclosed the alteration of the corneal endothelial morphology in type I diabetes mellitus as compared to normal subjects. The results indicated that type I diabetic corneas are more susceptible to environmental changes than type II corneas.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Histology and Histopathology. - 25 : 12 (2010), p. 1531-1537. -
További szerzők:Szalai Eszter (1984-) (orvos) Kertész Katalin Kemény-Beke Ádám (1968-2021) (szemész) Kettesy Beáta (1974-) (szemész) Berta András (1955-) (szemész, gyermekszemész)
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