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1.

001-es BibID:BIBFORM071355
Első szerző:Antal-Szalmás Péter (laboratóriumi szakorvos)
Cím:Serum levels of lectin complement pathway molecules do not determine the risk of bacterial infections in patients with cirrhosis / P. Antal-Szalmás, I. Földi, D. Tornai, T. Tornai, Zs. Vitális, I. Tornai, T. Dinya, M. Papp
Dátum:2016
Megjegyzések:SE1.5Serum levels of lectin complement pathway molecules do not determine the risk of bacterial infections in patientswith cirrhosisP. Antal-Szalmás1, I. Földi2, D. Tornai1, T. Tornai2, Zs. Vitális2, I Tornai2, T. Dinya3, M. Papp21Department of Laboratory Medicine, 2Department of Internal Medicine, Division of Gastroenterology, 3Institute of Surgery, Faculty ofMedicine, University of Debrecen, Debrecen, HungaryBacterial infections are a significant cause of morbidity and mortality in cirrhosis. Lectin pathway molecules of the complement system aresynthesized in the liver and have a pivotal role in the innate host defense against infectious organisms. Mannose-binding lectin (MBL) andficolins (FCNs) act as soluble pattern recognition molecules, while mannan-binding lectin serine proteases (MASPs) are effector molecules inelimination of the pathogens. Low levels of the functional proteins increase the risk of various infectious diseases but their significance hasscarcely been investigated in cirrhosis related bacterial infections.Sera of 266 patients with cirrhosis and 160 healthy subjects were assayed for the concentrations of FCN-2, FCN-3 and MASP-2 by ELISAs.In cirrhosis, a 5-year follow-up observational study was conducted to assess a possible association between lectin levels and development ofclinically significant bacterial infections (CSI) and mortality.The FCN-2, FCN-3 and MASP-2 levels were significantly lower in cirrhosis compared to healthy controls (505 vs. 769 ng/ml, 7,301 vs.10,797 ng/ml and 212 vs. 412 ng/ml, respectively, p < 0.001 for all) and decreased according to disease severity as rated by Child-Pughstage. In Kaplan-Meier analysis time to development of CSI was associated with low level of FCN-3 ( < 4,857 ng/ml, p = 0.028) but notFCN-2 ( < 427 ng/ml, p = 0.068) or MASP-2 deficiency (p = 0.368). Combined FCN deficiency even more than individual molecules wereable to predict the development of these episodes. Patients with low level of both FCNs had a cumulative risk of an infection of 52%as compared to 31% with normal level of FCNs (p = 0.021). In multivariate Cox-regression analysis, clinical factors but not the serumlectin profile remained an independent predictor of CSI. Prior episode of CSI and in a stepwise manner, the disease severity as rated byChild-Pugh stage conferred higher risk for development of CSI (HR: 2.64, 95% CI: 1.74?3.99, p < 0.001 and 2.11, 95%CI: 1.52-2.93, p < 0.001,respectively).In the present prospective study, diseases severity and prior episode of CSI but not the serum lectin profile were major determinants ofthe risk of CSI in cirrhosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Clinical chemistry and laboratory medicine 54 : 10 (2016), p. 162. -
További szerzők:Földi Ildikó (1981-) (orvos) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Tornai Tamás István (1984-) (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
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2.

001-es BibID:BIBFORM089479
Első szerző:Balogh Boglárka (belgyógyász)
Cím:Gut barrier failure : a piece in the puzzle of acute-on chronic liver failure syndrome development? / Boglarka Balogh, Zsuzsa Vitalis, Tamas Tornai, Istvan Tornai, David Tornai, Aniko Csillag, Peter Antal-Szalmas, Maria Papp
Dátum:2020
Megjegyzések:Introduction: Intestinal barrier dysfunction induced inflammation facilitates pathologic bacterial translocation (BT) which is a characteristic feature of liver cirrhosis (LC). BT plays a crucial role in the progression of LC leading to spontaneous bacterial peritonitis (SBP), bacteraemia and induction of proinflammatory responses causing various organ damages. Therefore, the serological hallmarksof gut barrier dysfunction in cirrhosis are able to predict the accelerated progression of liver disease. Methods: In a cohort of patients with decompensated cirrhosis (n=135) prospectively followed-up for 1 year and in healthy controls (HC) (n=50) the serological markers of functional/structural gut damage (intestinal-fatty acid binding protein, I-FABP), BT (Endotoxin core antibody, EndoCab IgA) and mucosal immune response (secretory IgA, Immunoglobulin free light chain (Ig FLC) kappa and lambda,) were investigated by means of ELISA. Results: Comparing the LC to HC group the serum concentration of all investigated markers weresignificantly higher in cirrhotic patients, although they did not show any association with the disease severity. Investigating the role of the serological markers in the development of ACLF we found that significance of the serum level of Ig FLC kappa in ACLF prediction is comparable to AD score based on AUC values. Furthermore, the ACLF rate was lower in patients with low serum concentration of Ig FLC kappa compared to the group with high serum concentration of this molecule. Conclusions: Ig FLC kappa can be a usable marker in the serological panel for the prediction of ACLF development in acute decompensated cirrhotic patients. Acknowledgements: EFOP 3.6.2-16-2017-00006 (LIVE LONGER).
Tárgyszavak:Orvostudományok Klinikai orvostudományok előadáskivonat
könyvrészlet
Megjelenés:Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project /Ed. Rakonczay Zoltán, Kiss Lóránd. - p. 62. -
További szerzők:Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai Tamás István (1984-) (belgyógyász) Tornai István (1954-) (belgyógyász, gasztroenterológus) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Csillag Anikó (1979-) (immunológus, biológus, angol-magyar szakfordító) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
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3.

001-es BibID:BIBFORM089481
Első szerző:Csillag Anikó (immunológus, biológus, angol-magyar szakfordító)
Cím:Filamentosus-actin related molecules : are they serologic hallmark of overwhelming damage-associated molecular patterns (DAMPs) in acute decompensation? / Aniko Csillag, Zsuzsa Vitalis, Tamas Tornai, Istvan Tornai, David Tornai, Boglarka Balogh, Peter Antal-Szalmas, Maria Papp
Dátum:2020
Megjegyzések:Introduction: The actin cytoskeleton has a fundamental function in cellular motility, integrity, structure and signaling mechanisms. In acute decompensated liver cirrhosis large quantities of filamentous actin (F-actin) as a danger signal is released from damaged and necrotic hepatic cells. Recently it also has been demonstrated that the presence of IgA type anti-F-actin antibodies is associated with the disease severity, unfavorable disease outcome and intestinal damage, as well. Thus, we hypothesized that the actin-scavenging system molecules in acute decompensation are able to predict the accelerated progression of liver disease. Methods: In a cohort of patients with decompensated cirrhosis (n=135) prospectively followed-up for 1 year and in healthy controls (HC, n=50) the serum levels of gelsolin and anti-F-actin IgA were investigated by means of ELISA. Results: Serum gelsolin levels were significantly higher in patients with acute decompensated liver cirrhosis (LC-AD) compared to healthy controls (HCONT) (p<0.0001). The frequency of anti-F-actin positivity was 65.4% (n=83/127) in LC-AD group (cut off: 25 U/mL). Our results demonstrated that in LC-AD group the serum gelsolin levels did not show correlation with the different disease severity, the presence of bacterial infection or renal failure at inclusion, similarly to the presence or absence of anti-F-actin IgA positivity. However, high serum level of gelsolin (>87.7 ?g/mL) is associated with short term (30 days) mortality. Conclusions: High serum level of gelsolin is likely to predict short term mortality both in cirrhotic patients with or without acute-on-chronic liver failure at inclusion. Acknowledgements: EFOP 3.6.2-16-2017-00006 (LIVE LONGER).
ISBN:978-963-306-764-2
Tárgyszavak:Orvostudományok Klinikai orvostudományok előadáskivonat
könyvrészlet
Megjelenés:"PROCEEDINGS OF THE EFOP-3.6.2- 16-2017-00006 (LIVE LONGER) PROJECT" / Ed. Rakonczay Zoltán, Kiss Lóránd. - p. 63. -
További szerzők:Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai Tamás István (1984-) (belgyógyász) Tornai István (1954-) (belgyógyász, gasztroenterológus) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Balogh Boglárka (1993-) (belgyógyász) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
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4.

001-es BibID:BIBFORM071451
Első szerző:Dinya Tamás (sebész szakorvos, onkológus szakorvos)
Cím:Functional polymorphisms of innate immunity receptors are not risk factors for the non-SBP type bacterial infections in cirrhosis / Dinya Tamás, Tornai Tamás, Vitális Zsuzsanna, Tornai István, Balogh Boglárka, Tornai Dávid, Antal-Szalmás Péter, Sümegi Andrea, Andrikovics Hajnalka, Bors András, Tordai Attila, Papp Mária
Dátum:2018
ISSN:1478-3223 1478-3231
Megjegyzések:Background&Aims: Pattern recognition receptors (PRRs) have a key role in the innate host defense. Functional polymorphisms of various PRRs have been established to contribute to an increased susceptibility to spontaneous bacterial peritonitis (SBP). Their role in the development of cirrhosis-associated bacterial infections (BI), beyond SBP or progressive disease course related to pathological bacterial translocation (BT) remains unknown. Methods: 349 patients with cirrhosis were genotyped for common NOD2 (R702W, G908R and L1007PfsinsC), TLR2 (-16934T>A), and TLR4 (D299G) gene variants. Incidence of BIs, decompensating events (ascites, variceal bleeding and hepatic encephalopathy) and liver-related death were assessed in a 5-year follow-up observational study. Pathological BT was assessed based on the presence of anti-microbial antibodies or lipopolysaccharide-binding protein (LBP) level. Results: In patients with ascites (n=88) only NOD2 gene variants were associated with an increased cumulative probability of SBP compared to wild-type (76.9%?19.9% vs. 30.9%?6.9%, PLogRank=0.047). Neither individual polymorphisms, nor combined PRR genetic profiles were associated with the risk of non-SBP type BI. Advanced disease stage (HR,[95%CI]: 2.11 [1.38-3.25]) and prior history of a BI episode (HR: 2.42 [1.58-3.72]) were the major clinical risk factors of a subsequent BI. The risk of a non-SBP type BI in patients with advanced disease and a prior BI was even higher (HR: 4.74 [2.68-8.39]). The frequency of anti-microbial antibodies and LBP levels did not differ between various PRR genotypes. Correspondingly, PRR genetic profile was not able to predict the long-term disease course. Conclusions: In cirrhosis, functional polymorphisms of PRRs did not improve the identification of patients with high risk of BI beyond SBP or progressive diseases course.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
pattern recognition receptors
genetic polymorphisms
cirrhosis
bacterial infection
complication
mortality
Megjelenés:Liver International. - 38 : 7 (2018), p. 1242-1252. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Balogh Boglárka (1993-) (belgyógyász) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Sümegi Andrea (1969-) (biológus) Andrikovics Hajnalka Bors András Tordai Attila Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:OTKA-115818
OTKA
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5.

001-es BibID:BIBFORM066819
Első szerző:Földi Ildikó (orvos)
Cím:Lectin-complement pathway molecules are decreased in patients with cirrhosis and constitute the risk of bacterial infections / Ildiko Foldi, Tamas Tornai, David Tornai, Nora Sipeki, Zsuzsanna Vitalis, Istvan Tornai, Tamas Dinya, Peter Antal-Szalmas, Maria Papp
Dátum:2017
ISSN:1478-3223
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Liver International 37 : 7 (2017), p. 1023-1031. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Sipeki Nóra (1987-) (általános orvos) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:K115818/2015/1
OTKA
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6.

001-es BibID:BIBFORM079252
035-os BibID:(WoS)000480384000004 (Scopus)85069723243
Első szerző:Mezei Zoltán András (orvos)
Cím:A DNA pool of FLT3-ITD positive DNA samples can be used efficiently for analytical evaluation of NGS-based FLT3-ITD quantitation : testing several different ITD sequences and rates, simultaneously / Zoltán A. Mezei, Dávid Tornai, Róza V. Földesi, László Madar, Andrea Sümegi, Mária Papp, Péter Antal-Szalmás
Dátum:2019
ISSN:0168-1656
Megjegyzések:Internal tandem duplication (ITD) in the fms-like tyrosine kinase 3 (FLT3) gene is one of the most frequent genetic alteration in acute myeloid leukemia (AML), and it is associated with worse clinical outcome. Not only the presence but also the size, localization and the rate of this variant or the presence of multiple ITDs has prognostic information. The traditional PCR based diagnostic methods cannot provide information about all of these parameters in one assay, however the application of next generation sequencing (NGS) technique can be a reliable solution for this diagnostic problem. In order to evaluate the analytical properties of an NGS-based FLT3-ITD detection assay a QC sample was prepared from DNA of AML patients containing 19 different FLT3-ITD variants identified by NGS. The higher the total read count was in a certain sample of the NGS run, the more ITD variant types could be detected. The maximal sensitivity of FLT3-ITD detection by NGS technique was as low as 0.007% FLT3-ITD/total allele rate, however, below 0.1% rate, the reproducibility of the quantitation was poor (CV>25%). DNA pools with several FLT3-ITDs can be used efficiently for analytical evaluation of NGS-based FLT3-ITD quantitation testing several different ITD sequences and rates, simultaneously.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Fms-like tyrosine kinase 3 (FLT3)
internal tandem duplication (ITD)
deep next generation sequencing (NGS)
analytical validation
Megjelenés:Journal Of Biotechnology. - 303 (2019), p. 25-29. -
További szerzők:Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Földesi Róza (1967-) (klinikai laboratóriumi kutató, PhD hallgató) Madar László (1972-) (klinikai laboratóriumi kutató) Sümegi Andrea (1969-) (biológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
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7.

001-es BibID:BIBFORM102220
Első szerző:Papp Mária (belgyógyász, gasztroenterológus)
Cím:Presepsin as a new biomarker for old expectations in the diagnosis and prognosis of bacterial infection in cirrhosis / Maria Papp, Tamas Tornai, David Tornai, Zsuzsanna Vitalis, Istvan Tornai, Peter Antal-Szalmas
Dátum:2015
ISSN:0270-9139
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Hepatology. - 62 : S1 (2015), p. 1227A. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
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8.

001-es BibID:BIBFORM065752
Első szerző:Papp Mária (belgyógyász, gasztroenterológus)
Cím:Presepsin teardown : pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis / Maria Papp, Tamas Tornai, Zsuzsanna Vitalis, Istvan Tornai, David Tornai, Tamas Dinya, Andrea Sumegi, Peter Antal-Szalmas
Dátum:2016
Megjegyzések:AIM: Bacterial infections are frequent complications in cirrhosis with significant mortality. Early laboratory diagnosis is essential but challenging. We aimed to evaluate the diagnostic and prognostic value of presepsin in cirrhosis associated bacterial infections. METHODS: 216 patients with cirrhosis were enrolled. At admission, presence of bacterial infections and level of plasma presepsin, serum CRP and PCT were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term mortality. RESULTS: 34.7% of patients had bacterial infection. Presepsin levels were significantly higher in patients with infection than without (median, 1002 vs. 477 pg/mL, p<0.001), increasing with the severity of infection (organ failure[OF]Yes vs. No: 2358 vs. 710 pg/mL, p<0.001). Diagnostic accuracy of presepsin for severe infections was similar to PCT and superior to CRP (AUC-ROC: 0.85, 0.85 and 0.66, respectively, p=NS for presepsin vs. PCT and p<0.01 for presepsin vs. CRP). At the optimal cut-off value of presepsin>1206 pg/mL sensitivity, specificity, PPV and NPV were as follows: 87.5%, 74.5%, 61.8% and 92.7%. The accuracy of presepsin, however, decreased in advanced stage of the disease or in the presence of renal failure, most probably because of the significantly elevated presepsin levels in non-infected patients. 28-day mortality rate was higher among patients with >1277 pg/mL compared to those with ?1277 pg/mL (46.9% vs. 11.6%, p<0.001). In a binary logistic regression analysis, however, only PCT [OR: 1.81, (95%CI: 1.09?3.01), p=0.022] but neither presepsin and nor CRP were independent risk factor for 28-day mortality after adjusting with MELD score and leukocyte count.CONCLUSION: Presepsin is a valuable new biomarker for defining severe infections in cirrhosis proving same efficacy as PCT. However, it is not a useful marker of short-term mortality.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
presepsin
cirrhosis
bacterial infection
organ failure
mortality
Megjelenés:World Journal of Gastroenterology 22 : 41 (2016), p. 1-14. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Sümegi Andrea (1969-) (biológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
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9.

001-es BibID:BIBFORM091813
035-os BibID:(cikkazonosító)94
Első szerző:Tornai Dávid (hepatológia, biomarker kutatás)
Cím:Abnormal ferritin levels predict development of poor outcomes in cirrhotic outpatients : a cohort study / David Tornai, Peter Antal-Szalmas, Tamas Tornai, Maria Papp, Istvan Tornai, Nora Sipeki, Tamas Janka, Boglarka Balogh, Zsuzsanna Vitalis
Dátum:2021
ISSN:1471-230X
Megjegyzések:Abstract Background: Both iron overload and iron deficient anemia can associate with cirrhosis. At the same time, inflammation might be continuously present in cirrhotic patients due to bacterial translocation and patients' susceptibility to infections. Ferritin is a sensitive and widely available marker of iron homeostasis, in addition it acts as an acute phase protein. Therefore, we evaluated the prognostic potential of serum ferritin in the longterm follow-up of cirrhotic outpatients. Methods: A cohort of 244 cirrhotic outpatients was recruited and followed for 2 years. We measured their serum ferritin levels in our routine laboratory unit at enrolment and investigated its association with clinical outcomes. Results: Ferritin serum level was higher in males and older patients than in females (median: 152.6 vs. 75 ?g/L, p<0.001) or younger individuals (median: 142.9 vs. 67.9 ?g/L, p=0.002). Patients who previously survived variceal bleeding had lower ferritin levels (median: 43.1 vs. 146.6 ?g/L, p<0.001). In multivariate regression models, including laboratory and clinical factors, lower (<40 ?g/L) ferritin concentration was associated with the development of decompensated clinical stage in patients with previously compensated cirrhosis (sHR: 3.762, CI: 1.616-8.760, p=0.002), while higher (>310 ?g/L) circulating ferritin levels were associated with increased risks of bacterial infections in decompensated patients (sHR: 2.335, CI: 1.193-4.568, p=0.013) and mortality in the whole population (HR: 2.143, CI: 1.174-3.910, p=0.013). Conclusion: We demonstrated usefulness of serum ferritin as a prognostic biomarker in cirrhosis, pointing out that both low and high concentrations need attention in these patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Bmc Gastroenterology. - 21 : 1 (2021), p. 1-13. -
További szerzők:Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Tornai Tamás István (1984-) (belgyógyász) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Sipeki Nóra (1987-) (általános orvos) Janka Tamás Balogh Boglárka (1993-) (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
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10.

001-es BibID:BIBFORM089190
Első szerző:Tornai Dávid (hepatológia, biomarker kutatás)
Cím:Increased sTREM-1 levels identify cirrhotic patients with bacterial infection and predict their 90-day mortality / Tornai David, Vitális Zsuzsanna, Jónás Alexa, Janka Tamás, Földi Ildikó, Tornai Tamás, Sipeki Nóra, Csillag Anikó, Balogh Boglárka, Sümegi Andrea, Földesi Róza, Papp Mária, Antal-Szalmás Péter
Dátum:2021
Megjegyzések:Background & Aims: Patients with cirrhosis are susceptible to bacterial infections (BIs) that are major causes of specific complications and mortality. However, the diagnosis of BIs can often be difficult in advanced disease stage since their symptoms may overlap with the ones of acute decompensation (AD). Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is released from monocytes/macrophages and neutrophils during activation and has been reported to correlate with activity of various inflammatory processes. We investigated its diagnostic and prognostic performance in patients with cirrhosis and BI. Methods: Sera of 269 patients were assayed for sTREM-1 by ELISA (172 outpatients and 97 patients with AD of whom 56 had BI). We investigated capacity of sTREM-1 to identify patients with BI and conducted a 90-day follow-up observational study to assess its possible association with short-term mortality. Results: sTREM-1 levels were significantly higher in patients with more severe liver disease, BI, and acute-on-chronic liver failure than in patients without these conditions. sTREM-1 had similar accuracy to CRP identifying BI [sTREM-1: AUROC (95%CI) 0.804 (0.711-0.897), p<0.0001, CRP: 0.791 (0.702-0.881) p<0.0001)] among AD patients. The combination of these two molecules and the presence of ascites into a composite score significantly increased their discriminative power (AUROC:0.878, 95%CI:0.812-0.944, p<0.0001). High sTREM-1 level (>660 pg/mL) was an independent predictor of 90-day mortality in patients with BI [HR: 2.941, (95%CI: 1.009-8.573), p=0.048] in our multivariate model. Conclusions: Use of sTREM-1 could increase the recognition of BIs in cirrhosis and help clinicians in mortality risk assessment of these patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
sTREM-1
bacterial infection
cirrhosis
acute decompensation
mortality
Megjelenés:Clinics and Research in Hepatology and Gastroenterology. - 45 : 5 (2021), p. 1-12. -
További szerzők:Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Jónás Alexa Janka Tamás Földi Ildikó (1981-) (orvos) Tornai Tamás István (1984-) (belgyógyász) Sipeki Nóra (1987-) (általános orvos) Csillag Anikó (1979-) (immunológus, biológus, angol-magyar szakfordító) Balogh Boglárka (1993-) (belgyógyász) Sümegi Andrea (1969-) (biológus) Földesi Róza (1967-) (klinikai laboratóriumi kutató, PhD hallgató) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
EFOP-3.6.1-16-2016- 00022
EFOP
EFOP- 3.6.2-16-2017-00006
EFOP
ÚNKP-19-4
ÚNKP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

11.

001-es BibID:BIBFORM102210
Első szerző:Tornai Tamás István (belgyógyász)
Cím:Soluble CD163 (SCD163) is a marker of infection in patients with cirrhosis and acute decompensation and an independent predictor of the short-term mortality / Tornai Tamás, Tornai Dávid, Sipeki Nóra, Földi Ildikó, Dinya Tamás, Vitalis Zsuzsanna, Antal-Szalmás Péter, Tornai István, Papp Mária
Dátum:2015
ISSN:0168-8278
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Journal Of Hepatology. - 62 : Supplement 2 (2015), p. S368. -
További szerzők:Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Sipeki Nóra (1987-) (általános orvos) Földi Ildikó (1981-) (orvos) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Tornai István (1954-) (belgyógyász, gasztroenterológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM071624
035-os BibID:(Cikkazonosító)399 (WOS)000419673100035 (Scopus)85040450338
Első szerző:Tornai Tamás István (belgyógyász)
Cím:Loss of tolerance to gut immunity protein, glycoprotein 2 (GP2) is associated with progressive disease course in primary sclerosing cholangitis / Tornai Tamas, Tornai David, Sipeki Nora, Tornai Istvan, Alsulaimani Rayan, Fechner Kai, Roggenbuck Dirk, Norman Gary L., Veres Gabor, Par Gabriella, Par Alajos, Szalay Ferenc, Lakatos Peter Laszlo, Antal-Szalmas Peter, Papp Maria
Dátum:2018
Megjegyzések:Glycoprotein 2[GP2] is a specific target of pancreatic autoantibodies[PAbs] in Crohn's disease(CD) and is involved in gut innate immunity processes. Our aim was to evaluate the prevalence and prognostic potential of PAbs in primary sclerosing cholangitis(PSC). Sixty-five PSC patients were tested for PAbs by indirect immunofluorescence and compared with healthy (n=100) and chronic liver disease controls(CLD, n=488). Additionally, a panel of anti-microbial antibodies and secretory (s)IgA levels were measured, as markers of bacterial translocation and immune dysregulation. PAbs were more frequent in PSC (46.2%) compared to controls(healthy:0% and CLD:4.5%), P<0.001, for each]. Occurrence of anti-GP2 antibody was 30.8% (20/65) and was exclusively of IgA isotype. Anti-GP2 IgA positive patients had higher sIgA levels (P=0.021). With flow-cytometry, 68.4% (13/19) of anti-GP2 IgA antibodies were bound with secretory component, suggesting an active retro-transportation of anti-GP2 from the gut lumen to the mucosa. Presence of anti-GP2 IgA was associated with shorter transplant-free survival [PLogRank<0.01] during the prospective follow-up (median, IQR: 87 [9-99] months) and remained an independent predictor after adjusting for Mayo risk score (HR: 4.69 [1.05-21.04], P=0.043). These results highlight the significance of gut-liver interactions in PSC. Anti-GP2 IgA might be a valuable tool for risk stratification in PSC and considered as a potential therapeutic target.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
primary sclerosing cholangitis
pancreatic autoantibodies
glycoprotein 2
CUZD1
secretory immunglobulin
gut failure
Megjelenés:Scientific Reports. - 8 : 1 (2018), p. 1-11. -
További szerzők:Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Sipeki Nóra (1987-) (általános orvos) Tornai István (1954-) (belgyógyász, gasztroenterológus) Alsulaimani, Rayan Fechner, Kai Roggenbuck, Dirk Norman, Gary L. Veres Gábor (orvos) Pár Gabriella Pár Alajos Szalay Ferenc (belgyógyász) Lakatos Péter (Semmelweis Egyetem) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:OTKA-115818
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
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