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1.

001-es BibID:BIBFORM015579
Első szerző:Balogh Zoltán (belgyógyász, gasztroenterológus, diabetológus)
Cím:Gemfibrozil increases paraoxonase activity in type 2 diabetic patients : a new hypothesis of beneficial action of fibrates? / Balogh Z., Seres I., Harangi M., Kovács P., Kakuk G., Paragh G.
Dátum:2001
ISSN:1262-3636
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Diabetes & Metabolism 27 : 5Pt1 (2001), p. 604-610. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Kakuk György (1938-2018) (belgyógyász) Paragh György (1953-) (belgyógyász)
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2.

001-es BibID:BIBFORM017427
Első szerző:Paragh György (belgyógyász)
Cím:Specific and scavenger low density lipoprotein receptors involved in the disturbed lipid metabolism of patients with non-insulin-dependent diabetes melitus are independent of obesity / György Paragh, Éva Kovács, Márton Szabolcs, Jenő Szabó, Zoltán Balogh, Péter Kovács, Gabriella Fóris
Dátum:1998
Megjegyzések:Comparative studies were performed on monocyte-derived macrophages (MDMs), prepared by a 72-hour incubation of blood monocytes obtained from patients with non-insulin-dependent diabetes mellitus (NIDDM) and age-matched obese and non-obese controls. The MDMs, after a 72-hour culturing, expressed both specific and scavenger low-density lipoprotein (LDL) receptors on their surfaces. To study the binding capacity of both receptor types, [125I]LDL and [125I] acetylated LDL (acLDL) were applied to cells and the labeled ligands were then monitored to estimate the rate of intracellular degradations. The LDL-induced inhibition of endogenous cholesterol synthesis and the acLDL-triggered apolipoprotein (apo) E secretion were also studied, as the biological marker of receptor activation. The results indicate that the binding capacities of both specific and scavenger LDL receptors were not reduced in MDMs of diabetic patients. However, the intracellular degradation after LDL incorporation was decreased. The LDL-induced inhibition of cholesterol synthesis and the acLDL-transmitted apo E secretion were also found to be decreased in the MDMs of patients with NIDDM as compared with the obese and non-obese control groups. The NIDDM-induced impaired signal transduction of both specific and scavenger LDL receptors suggests an unclarified functional alteration of both receptor structures
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Metabolism - Clinical And Experimental. - 47 : 9 (1998), p. 1070-1074. -
További szerzők:Kovács Éva Szabolcs Márton Szabó Jenő (belgyógyász, endocrinologus) Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Fóris Gabriella (1937-) (belgyógyász)
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3.

001-es BibID:BIBFORM013938
Első szerző:Paragh György (belgyógyász)
Cím:The effect of micronised fenofibrate on paraoxonase activity in patients with coronary heart disease / Paragh G., Seres I., Harangi M., Balogh Z., Illyés L., Boda J., Szilvássy Z., Kovács P.
Dátum:2003
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Diabetes & metabolism 29 : 6 (2003), p. 613-618. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Illyés László Boda J. Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
elektronikus változat
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4.

001-es BibID:BIBFORM017767
Első szerző:Peitl Barna (orvos, farmakológus)
Cím:The prandial insulin sensitivity-modifying effect of vagal simulation in rats / Barna Peitl, Róbert Döbrönte, József Németh, Géza Mezey, Péter Kovács, György Paragh, Zoltán Szilvássy
Dátum:2005
ISSN:0026-0495
Megjegyzések:The effect of left cervical vagal nerve stimulation was studied on insulin sensitivity to test the proposed permissive insulin-sensitizing role of hepatic vagal parasympathetic efferent pathways in fasted and fed anesthetized rats. In fed animals, electrical stimulation (square impulses: 25 V, 5 Hz, 0.5 milliseconds over 15 minutes) of the vagal nerve induced hyperglycemia and an increase in plasma insulin immunoreactivity. Atropine (1.0 mg/kg intravenously) induced insulin resistance estimated by rapid insulin sensitivity testing. This was amplified when the vagal nerve was stimulated. The insulin-resistant state developed by fasting was not modified by either treatment with atropine or electrical stimulation. We conclude that both parasympathetic cholinergic and noncholinergic vagal efferents modulate postprandial neurogenic insulin sensitivity adjustments.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
prandial insulin
vagal stimulation
modifying effect
Megjelenés:Metabolism-Clinical and Experimental. - 54 : 5 (2005), p. 579-583. -
További szerzők:Döbrönte Róbert Németh József (Pécs) Mezey Géza (1978-) (idegsebész) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Paragh György (1953-) (belgyógyász) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Internet cím:DOI
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5.

001-es BibID:BIBFORM024362
Első szerző:Schloot, Nanette C.
Cím:Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1 : two prospective, randomized, double-blind phase II trials / Nanette C. Schloot, Guido Meierhoff, Csaba Lengyel, Gyözö Vándorfi, József Takács, Pál Pánczél, László Barkai, László Madácsy, Tamás Oroszlán, Peter Kovács, Gábor Sütö, Tadej Battelino, Nora Hosszufalusi, György Jermendy
Dátum:2007
Megjegyzések:Background: Aim of this trial was to test whether heat shock protein peptide DiaPep277 treatment in adult and paediatric patients with recent-onset type 1 diabetes (T1D) is safe and whether it can preserve endogenous insulin production. Methods: Two studies were performed in a prospective, multicentre, double-blind, placebo-controlled trial. Fifty adult (study p520, aged 16-44 years) and 49 paediatric patients (study p521, 4-15 years) with recent-onset T1D were treated subcutaneously at four different time points with 0.2 mg or 1.0 mg DiaPep277 versus placebo and followed for 18 months. Adult patients were treated with 0.2 mg, 1.0 mg or 2.5 mg DiaPep277 versus placebo. Stimulated C-peptide served as readout for functional ?-cell-mass. Results: DiaPep277-treatment was not associated with severe side effects. No differences were found in placebo and DiaPep277 treated groups. In adults, a modest trend towards better maintenance of ?-cell function was observed in the 0.2 mg and 1.0 mg group, while there was significant loss of stimulated C-peptide in the placebo and 2.5 mg group. Paediatric patients with low HLA risk showed stable C-peptide levels until 13 months upon treatment with 1 mg DiaPep277. Despite similar stimulated C-peptide levels at baseline, children exhibited a more pronounced loss of ?-cell function over 18 months than adults (p = 0.0003). Conclusion: Administration of DiaPep277 seems safe and may have beneficial effects on C-peptide levels over time in some patients with T1D, but this finding was not accompanied by reduced HbA<sub>1c</sub> or insulin requirement. Studies with more patients and longer follow-up are needed to further study the effect of DiaPep277.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
PEPTIDES
Islets of Langerhans
INSULIN-SECRETING CELLS
INSULIN
Injections, Subcutaneous
Hypoglycemic Agents
Humans
HLA Antigens
Hemoglobin A, Glycosylated
Drug Therapy, Combination
Double-Blind Method
Dose-Response Relationship, Drug
Diabetes Mellitus, Type 1
Child
C-peptide
AUTOANTIBODIES
Adult
Adolescent
urticaria
unspecified side effect
randomized controlled trial
protein blood level
priority journal
phase 2 clinical trial
pancreas islet cell function
pancreas islet beta cell
multiple drug dose
multicenter study
menstrual irregularity
Male
major clinical study
insulin synthesis
insulin dependent diabetes mellitus
injection site dermatitis
immunotherapy
hypoglycemia
human
HLA matching
high risk population
hemoglobin blood level
Female
drug tolerance
drug safety
drug fever
drug dose increase
drug dose comparison
double blind procedure
dizziness
controlled study
controlled clinical trial
clinical trial
cell density
ARTICLE
antibody titer
Age Distribution
unclassified drug
placebo
peptide p277
mannitol
HLA DR3 antigen
HLA DR antigen
hemoglobin A1c
heat shock protein 60
diapep277
C peptide
antidiabetic agent
Type 1 diabetes mellitus
PREVENTION
Human trials
Hsp60
HbA<sub>1c</sub>
Megjelenés:Diabetes/metabolism research and reviews. - 23 : 4 (2007), p. 276-285. -
További szerzők:Meierhoff, Guido Lengyel Csaba (Miskolc) Vándorfi Győző Takács József Pánczél Pál Barkai László (1958-) (gyermekgyógyász) Madácsy László (Szeged) Oroszlán Tamás Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Sütő Gábor Battelino, Tadej Hosszúfalusi Nóra Jermendy György
Internet cím:DOI
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6.

001-es BibID:BIBFORM028449
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:Insulin resistance occurs in parallel with sensory neuropathy in streptozotocin-induced diabetes in rats : differential response to early vs late insulin supplementation / Szilvássy Z., Németh J., Kovács P., Paragh G., Sári R., Vígh L., Peitl B.
Dátum:2012
Megjegyzések:We investigated whether progressive sensory neuropathy was accompanied by changes in whole-body insulin sensitivity (WBIS) in rats made diabetic by streptozotocin (STZ). The effects of early and late insulin supplementation were also studied. The STZ-treated rats failed to gain weight and exhibited stable hyperglycemia and low plasma insulin levels with a decrease in nerve conduction velocity (NCV) measured in A and C fibers of the saphenous nerve. A decreased sensory neuropeptide (SNP) release such as that of substance P, somatostatin, and calcitonin gene-related peptide determined from organ fluid of tracheal preparations subjected to electrical field stimulation also occurred in diabetic animals. These features were accompanied by a decrease in WBIS measured by hyperinsulinemic-euglycemic glucose clamping and a decrease in insulin-stimulated glucose uptake in cardiac and gastrocnemius muscle. When insulin supplementation with slow-release implants (2 IU/d) was started 4 weeks after STZ injection, blood glucose level normalized. Both insulin sensitivity and sensory nerve function reflected in either NCV or SNP release completely recovered by the 12th post-STZ week. When the insulin implants were applied from the eighth post-STZ week, both WBIS and glucose uptake remained significantly decreased, with a seriously impaired NCV and SNP release with strong hyperglycemia. Late insulin supplementation, however, even by using double implantation from the 10th post-STZ week, was unable to restore blood glucose, WBIS, NCV, and SNP release by the 12th week. Insulin resistance occurs in parallel with sensory neuropathy in STZ-diabetic rats. Both can be improved by early but not late insulin supplementation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Metabolism. - 61 : 6 (2012), p. 776-786. -
További szerzők:Németh József (1954-) (vegyész, analitikus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Paragh György (1953-) (belgyógyász) Sári Réka (farmakológus) Vígh László (orvos Szeged) Peitl Barna (1972-) (orvos, farmakológus)
Pályázati támogatás:TÁMOP-4.2.2.-08/1-2008-0014
TÁMOP
75965
OTKA
NKFP_07-A2-2008-0260
Egyéb
GOP-1.1.207/1-2008-0004
Egyéb
OM00174/2008
Egyéb
GOP-1.1.1-07/1-2008-0032
Egyéb
GOP-1.2.1-082009-0023
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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