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001-es BibID:	BIBFORM017427
Első szerző:	Paragh György (belgyógyász)
Cím:	Specific and scavenger low density lipoprotein receptors involved in the disturbed lipid metabolism of patients with non-insulin-dependent diabetes melitus are independent of obesity / György Paragh, Éva Kovács, Márton Szabolcs, Jenő Szabó, Zoltán Balogh, Péter Kovács, Gabriella Fóris
Dátum:	1998
Megjegyzések:	Comparative studies were performed on monocyte-derived macrophages (MDMs), prepared by a 72-hour incubation of blood monocytes obtained from patients with non-insulin-dependent diabetes mellitus (NIDDM) and age-matched obese and non-obese controls. The MDMs, after a 72-hour culturing, expressed both specific and scavenger low-density lipoprotein (LDL) receptors on their surfaces. To study the binding capacity of both receptor types, [125I]LDL and [125I] acetylated LDL (acLDL) were applied to cells and the labeled ligands were then monitored to estimate the rate of intracellular degradations. The LDL-induced inhibition of endogenous cholesterol synthesis and the acLDL-triggered apolipoprotein (apo) E secretion were also studied, as the biological marker of receptor activation. The results indicate that the binding capacities of both specific and scavenger LDL receptors were not reduced in MDMs of diabetic patients. However, the intracellular degradation after LDL incorporation was decreased. The LDL-induced inhibition of cholesterol synthesis and the acLDL-transmitted apo E secretion were also found to be decreased in the MDMs of patients with NIDDM as compared with the obese and non-obese control groups. The NIDDM-induced impaired signal transduction of both specific and scavenger LDL receptors suggests an unclarified functional alteration of both receptor structures
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Metabolism - Clinical And Experimental. - 47 : 9 (1998), p. 1070-1074. -
További szerzők:	Kovács Éva Szabolcs Márton Szabó Jenő (belgyógyász, endocrinologus) Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Fóris Gabriella (1937-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM017419
Első szerző:	Paragh György (belgyógyász)
Cím:	Treatment possibility of hypercholesterolaemia associated with hypertriglyceridaemia / Paragh Gy., Balogh Z., Boda J., Kovács P., Kárpáti I., Szabó J., Leövey A.
Dátum:	1997
Megjegyzések:	Thirty patients were investigated with hyperlipoproteinaemia, 15 patients with non-insulin dependent diabetes mellitus (NIDDM) and 15 with primary hyperlipoproteinaemia. The patients took 250 mg acipimox (5-metyl-pyrazine-carboxylic acid 4-oxide) 3 times per day for 2 months. Serum examinations were performed before and after 1 and 2 months of acipimox administration. After treatment the cholesterol and triglyceride levels decreased in both groups. Patients with NIDDM had 11% increase of high density lipoprotein-cholesterol (HDL-C) level at the end of the first, and 18% increase at the end of the second month, while patients with primary hyperlipoproteinaemia did not change significantly. The low density lipoprotein (LDL) level did not change significantly in either groups of patients. The apolipoprotein A 1 (apo A 1) levels increased significantly during the second month of acipimox administration. Uric acid levels decreased in both groups, but significant change could be detected mainly in the NIDDM group. Serum glucose level did not change in the non-diabetic patients, while it decreased significantly in the NIDDM group.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Megjelenés:	Acta Biologica Hungarica. - 48 : 3 (1997), p. 359-367. -
További szerzők:	Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Boda Judit (belgyógyász, endokrinológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Kárpáti István (1955-) (belgyógyász, nephrológus) Szabó Jenő (belgyógyász, endocrinologus) Leövey András (1926-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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