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001-es BibID:	BIBFORM029807
Első szerző:	Kotán Róbert (sebész)
Cím:	Micro-rheological changes during experimental acute pancreatitis in the rat / Robert Kotan, Norbert Nemeth, Ferenc Kiss, Janos Posan, Kornel Miszti-Blasius, Laszlo Toth, Istvan Furka, Iren Miko, Peter Sapy, Zsolt Szentkereszty
Dátum:	2012
ISSN:	1386-0291
Megjegyzések:	Although microcirculatory disturbances play pivotal role in the pathomechanism of acute pancreatitis (AP), very few papers can be found which had been tested any of hemorheological parameters. The aim of our study was to analyze the hemorheological changes in cerulein-induced experimental acute pancreatitis in rat in two doses (5 and 10 [mű]g/kg, s.c.). Male and female rats were subjected to Control group, or AP with 5 or 10 [mű]g/kg cerulein groups. Blood samplings (lateral caudal vein) were completed before cerulein administration, and 1, 2 and 24 hours later. Hematological parameters, amylase activity, erythrocyte deformability (ektacytometry) and aggregation (light-transmission method) were tested. The presence of AP could be confirmed by amylase testing and histological examination. The earliest impairment of the red blood cell deformability could be observed 1 hour after cerulein administration in 10 [mű]g/kg dosage. Female animals had the worst rheological results with high mortality. In conclusion, subcutaneously administrated cerulein in dosage of 5 and 10 [mű]g/kg resulted in AP in rats, with significant changes in red blood cell deformability and alterations in erythrocyte aggregation. This model seems to be suitable for further comparative studies.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény Red blood cell deformability red blood cell aggregation acute pancreatitis rat model cerulein induced-pancreatitis
Megjelenés:	Clinical Hemorheology And Microcirculation 51 : 4 (2012), p. 255-264. -
További szerzők:	Németh Norbert (1975-) (kutatóorvos) Kiss Ferenc (1982-) (kutatóorvos) Pósán János (1976-) (sebész) Miszti-Blasius Kornél (1977-) (laboratóriumi szakorvos) Tóth László (1971-) (patológus) Furka István (1935-2021) (sebész, urológus, kutatóorvos) Mikó Irén (1948-) (kutató sebész) Sápy Péter (1942-) (sebész) Szentkereszty Zsolt (1961-) (sebész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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001-es BibID:	BIBFORM017910
035-os BibID:	PMID:22240361
Első szerző:	Németh Norbert (kutatóorvos)
Cím:	Following-up hemorheological consequences of gonadectomy in male and female rats / Németh Norbert, Kiss Ferenc, Magyar Zsuzsanna, Miszti-Blasius Kornél, Furka István
Dátum:	2012
Megjegyzések:	Growing number of clinical and experimental data reflect to the gender differences of hemorheological parameters. However, little is known about the potential hemorheological effect of gonadectomy and consequent changes in sex hormone concentration. Adult, same-aged male and female rats were involved in the study. In control male and female group no surgical intervention was performed. In gonadectomized (GoE) male and female groups bilateral orchidectomy or ovariectomy were completed. Body weight measurement and blood sampling were carried out in the 1st, 2nd and 3rd postoperative months. The GoE females had significant bodyweight augmentation and their plasma estrogen concentration decreased by 40-45% by the 1st postoperative month, while in males the testosterone level was not detectable after gonadectomy. Leukocyte and platelet counts moderately increased in GoE males. Elongation index values of erythrocytes slightly decreased in both genders after gonadectomy, showing converging values. Erythrocyte aggregation index values of GoE females significantly raised by the 2nd month. It can be concluded that gonadectomy in rats resulted in alteration (dominantly impairment) of blood microrheological parameters, by different manner in males and females. Supposedly decrease in estrogen can cause more expressed hemorheological changes than the cessation of testosterone.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény Gonadectomy gender differences laboratory animals red blood cell aggregation red blood cell deformability
Megjelenés:	Clinical Hemorheology and Microcirculation. - 50 : 4 (2012), p. 231-243. -
További szerzők:	Kiss Ferenc (1982-) (kutatóorvos) Magyar Zsuzsanna (1981-) (orvos) Miszti-Blasius Kornél (1977-) (laboratóriumi szakorvos) Furka István (1935-2021) (sebész, urológus, kutatóorvos)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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