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001-es BibID:BIBFORM074784
Első szerző:Balogh Nóra (Pszichológus)
Cím:Neurocognitive changes in patients with schizophrenia during relapse and early remission / Nóra Balogh, Anikó Égerházi, Roland Berecz
Dátum:2015
ISSN:0213-6163
Megjegyzések:ABSTRACT Background and Objectives: Several studies have demonstrated that pa- tients with schizophrenia have impaired cognitive functioning. In the literature there have been controversial results about the cognitive deficits occurring in the different states of the illness. Furthermore, there have been relatively few studies to investigate the associa- tions between neurocognitive deficits and clinical status over time.In order to follow the changes of neurocognitive subfunctions during relapse and early remission (clinically stable state), in the present study patients with schizophrenia were tested in the acute phase and in clinically stable state, and then the results were correlated with clinical symptoms.Methods: Forty-two patients diagnosed with schizophrenia based on diagnostic inter- views by clinicians and 43 normal controls were studied. Neurocognitive skills were eval- uated with six subtests of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Among patients with schizophrenia, symptom severity was assessed with the Positive and Negative Syndrome Scale (PANSS).Results: Patients with schizophrenia performed significantly worse in all neurocogni- tive subtests compared to healthy controls at both relapse and clinically stable state. At fol- low-up these cognitive changes improved, however still marked dysfunctions were ob- served. The negative symptoms in the PANSS and CANTAB tests were negatively correlated with both results during relapse and clinically stable state.Conclusions: Cognitive impairment exists among patients with schizophrenia com- pared to healthy subjects during both relapse and early remission suggesting that these deficits might be permanent.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
schizophrenia
neurocognition
CANTAB
Megjelenés:European Journal Of Psychiatry. - 29 : 3 (2015), p. 199-209. -
További szerzők:Égerházi Anikó (1957-) (neurológus, pszichiáter, pszichoterapeuta) Berecz Roland (1970-) (pszichiáter szakorvos)
Pályázati támogatás:TÁMOP-4.2.1/B09/1/KONV-2010-0007
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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