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001-es BibID:BIBFORM056215
Első szerző:Clemens Béla (neurológus)
Cím:Valproate treatment normalizes EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients / B. Clemens, S. Puskás, M. Besenyei, N. Zs. Kovács, T. Spisák, S. A. Kis, M. Emri, K. Hollody, A. Fogarasi, I. Kondákor, I. Fekete
Dátum:2014
Megjegyzések:To investigate the effect of chronic VPA treatment of EEG functional connectivity in successfully treated idiopathic generalized epilepsy (IGE) patients. PATIENTS AND METHODS: 19-channel waking, resting-state EEG records of 26 IGE patients were analyzed before treatment (IGE) and after the 90th day of treatment (VPA), in seizure-free condition. Three minutes of artifact-free EEG background activity (without epileptiform potentials) was analyzed for each patient in both conditions. A group of 26 age-matched healthy normative control persons (NC) was analyzed in the same way. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography) to localize multiple distributed sources of EEG activity. Current source density time series were generated for 33 regions of interest (ROI) in each hemisphere for four frequency bands. Pearson correlation coefficients (R) were computed between all ROIs in each hemisphere, for four bands across the investigated samples. R values corresponded to intrahemispheric, cortico-cortical functional EEG connectivity (EEGfC). Group and condition differences were analyzed by statistical parametric network method. MAIN RESULTS: p<0.05, corrected for multiple comparisons: (1) The untreated IGE group showed increased EEGfC in the delta and theta bands, and decreased EEGfC in the alpha band (as compared to the NC group); (2) VPA treatment normalized EEGfC in the delta, theta and alpha bands; and (3) degree of normalization depended on frequency band and cortical region. CONCLUSIONS: VPA treatment normalizes EEGfC in IGE patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
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Megjelenés:Epilepsy Research. - 108 : 10 (2014), p. 1896-1903. -
További szerzők:Puskás Szilvia (1979-) (neurológus) Bessenyei Mónika (1970-) (neurológus, csecsemő- és gyermekgyógyász) Kovács N. Zs. Spisák Tamás (1986-) (programtervező matematikus, informatikus) Kis Sándor Attila (1973-) (fizikus) Emri Miklós (1962-) (fizikus) Hollódy Katalin (1955-) (csecsemő- és gyermekgyógyász) Fogarasi András Kondákor István (1950-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter)
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001-es BibID:BIBFORM017054
Első szerző:Clemens Béla (neurológus)
Cím:EEG functional connectivity of the intrahemispheric cortico-cortical network of idiopathic generalized epilepsy / Clemens B., Puskás S., Bessenyei M., Emri M., Spisák T., Koselák M., Hollódy K., Fogarasi A., Kondákór I., Füle K., Fekete I.
Dátum:2011
ISSN:0920-1211 1872-6844
Megjegyzések:Intrahemispheric, cortico-cortical EEG functional connectivity (fC) was investigated in untreated patients with idiopathic generalized epilepsy (IGE) in this explorative study. PATIENTS AND METHODS: Group comparison was carried out between 19, drug-naive IGE patients and 19, matched healthy persons. 90x2s of 19 channels waking, interictal background EEG signal (without epileptiform potentials) were processed to the LORETA (low resolution electromagnetic tomography) software to compute current source density for 2394 voxels representing parcels of the cerebral cortex for 25 very narrow bands of 1Hz bandwidth (VNBs) from 1 to 25Hz. EEG fC was investigated among the already localized sources. Pearson correlation coefficients (R) were computed among the 33 regions of interest (ROI) within the left and within the right hemisphere, separately. Group differences were computed by means of t-statistics. Corrected p<0.05 differences were accepted as statistically significant. MAIN RESULTS: (1) The anatomical patterns of the fC differences showed great frequency-dependency. (2) Hemispheric asymmetry was prominent within most VNBs. (3) Decreased fC in the IGE group was found across all VNBs in the 1-6Hz frequency range as compared to mixed patterns comprising both increased and decreased fC at >6Hz frequencies. (4) In the 5-25Hz range, decreased fC dominated in the anterior, increased fC in the posterior parts of the cortex. (5) The results delineated an anterior and a posterior network. DISCUSSION: (1) Decreased fC in the 1-6Hz band might indicate some relationship to yet hidden structure network abnormalities. (2) The anatomical patterns of fC indicate frequency-dependent, pathological coupling and decoupling processes in the interictal state. (3) The two networks might help to understand seizure liability and seizure precipitation in IGE. SIGNIFICANCE: This is the first study to explore EEG fC in the interictal condition of IGE patients. The importance of EEG frequencies in evaluating fC in IGE was demonstrated and starting points for further research were given.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Epilepsy Research. - 96 : 1-2 (2011), p. 11-23. -
További szerzők:Puskás Szilvia (1979-) (neurológus) Bessenyei Mónika (1970-) (neurológus, csecsemő- és gyermekgyógyász) Emri Miklós (1962-) (fizikus) Spisák Tamás (1986-) (programtervező matematikus, informatikus) Koselák Mihály (1986-) (informatikus) Hollódy Katalin (1955-) (csecsemő- és gyermekgyógyász) Fogarasi András Kondákor István (1950-) (neurológus) Füle K. Fekete István (1951-) (neurológus, pszichiáter)
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