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001-es BibID:	BIBFORM076532
035-os BibID:	(cikkazonosító)e00997
Első szerző:	Biró Attila (okleveles biomérnök)
Cím:	Isolation of allithiamine from Hungarian red sweet pepper seed (Capsicum annuum L.) / Biro Attila, Gál Ferenc, Hegedűs Csaba, Batta Gyula, Cziáky Zoltán, Peitl Barna, Stündl László, Gyémánt Gyöngyi, Remenyik Judit
Dátum:	2018
ISSN:	2405-8440
Megjegyzések:	A natural fat-soluble thiamine derivative, namely N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(2E)-5-hydroxy-3-(prop-2-en-1-yldisulfanyl)pent-2-en-2-yl]formamide (allithiamine) has been identified only in garlic (Allium sativum) until now. Hungarian red sweet pepper (Capsicum annuum) was found as a new source of allithiamine. Extraction procedure and analytical method were developed for the isolation of allithiamine and a chemical synthesis of the compound was also developed. First solid-liquid extraction was performed with 96 % ethanol to isolate allithiamine from pepper seeds. Thereafter, solid phase extraction was applied from ethanolic extract using C18 cartridge to concentrate and purify samples for further analysis. The structure of the synthesized and the isolated compounds was verified by reverse phase HPLC, HPLC-MS, MALDTOF MS and NMR. Furthermore, effect of allithiamine was investigated on streptozotocin-induced diabetic mice with neuropathy. The results show that neuropathic pain sensation is improved by allithiamine treatment similarly to benfothiamine.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Analytical chemistry Food science
Megjelenés:	Heliyon. - 4 : 12 (2018), p. 1-17. -
További szerzők:	Gál Ferenc (1964-) (élelmiszertechnológia) Hegedűs Csaba (1983-) (Molekuláris biológus, Cera-Med Kft. Debrecen) Batta Gyula (1953-) (molekula-szerkezet kutató) Cziáky Zoltán Peitl Barna (1972-) (orvos, farmakológus) Stündl László (1970-) (agrármérnök) Gyémánt Gyöngyi (1960-) (vegyész) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00042 GINOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM079346
035-os BibID:	(cikkazonosító)7213913 (WOS)000464702500001 (Scopus)85065782402
Első szerző:	Kiss Rita (laboratóriumi diagnosztika szakorvos)
Cím:	Diosgenin and Its Fenugreek Based Biological Matrix Affect Insulin Resistance and Anabolic Hormones in a Rat Based Insulin Resistance Model / Kiss Rita, Pesti-Asbóth Georgina, Szarvas Mária Magdolna, Stündl László, Cziáky Zoltán, Hegedűs Csaba, Kovács Diána, Badale Andrea, Máthé Endre, Szilvássy Zoltán, Remenyik Judit
Dátum:	2019
ISSN:	2314-6133 2314-6141
Megjegyzések:	Fenugreek is known since ancient times as a traditional herbal medicine of its multiple beneficial effects. Fenugreek's most studied and employed effect is its hypoglycemic property, but it can also be useful for the treatment of certain thyroid disorders or for the treatment of anorexia. The regulation of glucose homeostasis is a complex mechanism, dependent on the interaction of different types of hormones and neurotransmitters or other compounds. For the study of how diosgenin and fenugreek seeds modify insulin sensitivity, we used a rat insulin resistance model induced by high-fat diet. Diosgenin in three different doses (1mg/bwkg, 10mg/bwkg, and 50mg/bwkg, respectively) and fenugreek seed (0.2 g/bwkg)were administered orally for 6weeks. Insulin sensitivity was determined by hyperinsulinemic euglycemic glucose clamp method. Our research group found that although glucose infusion rate was not significantly modified in either group, the increased insulin sensitivity index and high metabolic clearance rate of insulin found in the 1 mg/kg diosgenin and the fenugreek seed treated group suggested an improved peripheral insulin sensitivity. Results from the 10 mg/kg diosgenin group, however, suggest a marked insulin resistance. Fenugreek seed therapy results on the investigated anabolic hormones support the theory that, besides insulin and gastrointestinal peptides, the hypothalamichypopituitary axis regulated hormones synchronized action with IGF-1 also play an important role in the maintaining of normal glucose levels. Both diosgenin and fenugreek seeds are capable of interacting with substrates of the above-mentioned regulatory mechanisms, inducing serious hormonal disorders. Moreover, fenugreek seeds showed the ability to reduce the thyroid hormone levels at the periphery and to modify the T4/T3 ratio. It means that in healthy people this effect could be considered a severe side effect; however, in hypothyroidism this effect represents a possibility of alternative natural therapy.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Diosgenin Fenugreek Insulin Resistance Anabolic Hormones Rat
Megjelenés:	Biomed Research International. - 2019 (2019), p. 1-13. -
További szerzők:	Pesti-Asbóth Georgina (1990-) (élelmiszerbiztonsági és -minőségi mérnök) Szarvas Mária Magdolna (1989-) (élelmiszeripari mérnök) Stündl László (1970-) (agrármérnök) Cziáky Zoltán Hegedűs Csaba (1983-) (Molekuláris biológus, Cera-Med Kft. Debrecen) Kovács Diána Klára (1985-) (Molekuláris biológus) Badale, Andrea (1986-) (gyógyszerész) Máthé Endre (1964-) (genetikus, molekuláris sejtbiológus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész)
Pályázati támogatás:	EFOP-3.6.2-16-2017-00009 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM076719
035-os BibID:	(cikkazonosító)3278 (WoS)000454523000228 (Scopus)85058727337
Első szerző:	Kun-Nemes Andrea (okleveles élelmiszermérnök)
Cím:	Determination of Flavonoid and Proanthocyanidin Profile of Hungarian Sour Cherry / Nemes Andrea, Szőllősi Erzsébet, Stündl László, Biró Attila, Homoki Judit, Szarvas Mária, Balogh Péter, Cziáky Zoltán, Remenyik Judit
Dátum:	2018
ISSN:	1420-3049
Megjegyzések:	Hungarian sour cherries (SC) are excellent source of anthocyanin (concentrations (100?300 mg in 100 g fresh fruit) and melatonin (0.15 mg in 100 g fresh fruit), but other flavonoid derivatives also can be isolated by aqueous alcoholic extraction. We have developed a new process for extracting non-extractable procyanidines bound to the membrane, proteins, and fibers. These compounds were seperated with UHPLC-MS methods, and the structure of individual components were identified on the basis of their mass fragmentation spectra. The antioxidant capacity of soluble and non-soluble antioxidants were measured with ferric reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity (DPPH), trolox equivalent antioxidant capacity (TEAC) assays, and compared to the new measurement methods of water-soluble antioxidant capacity (ACW), lipid-soluble antioxidant capacity (ACL). Furthermore, total phenolic content (TPC) and total procyanidin content (PAC) were determinated. As a result of our investigation, we found that the solvent combination, where in the first step is water?ethanol (1:1), then 100% ethanol were suitable for the extraction of the extractable antioxidants. However, the chemiluminescence method that is based on the elimination of the superoxide radical is more accurate than other colorimetric methods which measure antioxidant capacity.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk sour cherry anthocyanins extractable polyphenols non-extractable polyphenols
Megjelenés:	Molecules. - 23 : 12 (2018), p. 1-20. -
További szerzők:	Szőllősi Erzsébet (1983-) (biológus) Stündl László (1970-) (agrármérnök) Biró Attila (1988-) (okleveles biomérnök) Homoki Judit (1978-) (biológus) Szarvas Mária Magdolna (1989-) (élelmiszeripari mérnök) Balogh Péter (1970-) (agrármérnök) Cziáky Zoltán Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00042 GINOP 20428-3/2018/FEKUTSTRAT Egyéb
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM116373
035-os BibID:	(cikkazonosító)e0290310 (WoS)001051745900088 (Scopus)85168299624
Első szerző:	Pesti-Asbóth Georgina (élelmiszerbiztonsági és -minőségi mérnök)
Cím:	Monitoring physiological processes of fast-growing broilers during the whole life cycle : Changes of redox-homeostasis effected to trassulfuration pathway predicting the development of non-alcoholic fatty liver disease / Georgina Pesti-Asbóth, Endre Szilágyi, Piroska Bíróné Molnár, János Oláh, László Babinszky, Levente Czeglédi, Zoltán Cziáky, Melinda Paholcsek, László Stündl, Judit Remenyik
Dátum:	2023
ISSN:	1932-6203
Megjegyzések:	In the broiler industry, the average daily gain and feed conversion ratio are extremely favorable, but the birds are beginning to approach the maximum of their genetic capacity. However, as a consequence of strong genetic selection, the occurrence of certain metabolic diseases, such as myopathies, ascites, sudden cardiac death and tibial dyschondroplasia, is increasing. These metabolic diseases can greatly affect the health status and welfare of birds, as well as the quality of meat. The main goal of this study was to investigate the changes in the main parameters of redox homeostasis during the rearing (1-42 days of age) of broilers with high genetic capacity, such as the concentrations of malondialdehyde, vitamin C, vitamin E, and reduced glutathione, the activities of glutathione peroxidase and glutathione reductase, and the inhibition rate of superoxide dismutase. Damage to the transsulfuration pathway during growth and the reason for changes in the level of homocysteine were investigated. Further, the parameters that can characterize the biochemical changes occurring in the birds were examined. Our study is the first characterize plasma albumin saturation. A method was developed to measure the levels of other small molecule thiol components of plasma. Changes in redox homeostasis induce increases in the concentrations of tumor necrosis factor alpha and inflammatory interleukins interleukin 2, interleukin 6 and interleukin 8 in broilers reared according to current large-scale husbandry technology and feeding protocols. A significant difference in all parameters tested was observed on the 21st day. The concentrations of cytokines and homocysteine increased, while the concentrations of glutathione and cysteine in the plasma decreased. Our findings suggest that observed changes in the abovementioned biochemical indices have a negative effect on poultry health.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Animals Chickens Glutathione Homeostasis Non-alcoholic Fatty Liver Disease Oxidation-Reduction Physiological Phenomena
Megjelenés:	Plos One. - 18 : 8 (2023), p. 1-28. -
További szerzők:	Szilágyi Endre (1986-) Bíróné Molnár Piroska (1970-) (biokémia) Oláh János (1976-) (állattenyésztés) Babinszky László (1950-) (agrár) Czeglédi Levente (1977-) (agrármérnök) Cziáky Zoltán Paholcsek Melinda (1984-) (molekuláris biológus, genetikus) Stündl László (1970-) (agrármérnök) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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