CCL

Összesen 2 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM070612
035-os BibID:(WoS)000416505400018 (Scopus)85028574106
Első szerző:Mezei Zoltán András (orvos)
Cím:Factor XIII levels and factor XIII B subunit polymorphisms in patients with venous thromboembolism / Zoltán A. Mezei, Éva Katona, Judit Kállai, Zsuzsanna Bereczky, Laura Somodi, Éva Molnár, Bettina Kovács, Tünde Miklós, Éva Ajzner, László Muszbek
Dátum:2017
ISSN:0049-3848
Megjegyzések:Background: The association of plasma factor XIII (FXIII) level with venous thromboembolism (VTE) is still controversial and the effect of sex and FXIII B subunit (FXIII-B) polymorphisms in this respect have not been explored.Objectives: 1/ To determine FXIII activity and antigen levels in patients with a history of VTE and how they are influenced by sex and FXIII-B polymorphisms. 2/ To explore the association of FXIII levels and FXIII-B polymorphisms with the risk of VTE.Methods: 218 VTE patients and equal number of age and sex matched controls were enrolled in the study. FXIII activity was measured by ammonia release assay; FXIII-A2B2 and FXIII-B levels were determined by ELISAs. FXIII-B polymorphisms were identified by RT-PCR using melting point analysis.Results: Adjusted FXIII activity and FXIII-A2B2 antigen levels were significantly higher in females with a history of VTE than in the respective controls. FXIII-B levels were significantly lower in male VTE patients than in controls. FXIII-A2B2 antigen levels in the upper tertile increased the risk of VTE in females (adjusted OR: 2.52; CI:1.18?5.38). Elevated FXIII-B antigen level had a protective effect only in males (adjusted OR: 0.19; CI:0.08?0.46). FXIII-B Intron K c.1952+144 C > G polymorphism significantly lowered FXIII activity, FXIII-A2B2 and FXIII-B antigen levels in both groups. FXIII-B polymorphisms did not influence the risk of VTE.Conclusions: In VTE patients the changes of FXIII level and their effect on the risk of VTE show considerable sexspecific differences. Intron K polymorphism results in decreased FXIII levels, but does not influence the risk of VTE.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Factor XIII
Factor XIII-B subunit
Polymorphisms
Venous thromboembolism
Megjelenés:Thrombosis Research. - 158 (2017), p. 93-97. -
További szerzők:Katona Éva (1961-) (klinikai biokémikus) Kállai Judit (1983-) (molekuláris biológus) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Somodi Laura (1991-) (klinikai laboratóriumi kutató) Molnár Éva (1977-) (analitikus) Kovács Bettina (1975-) (orvos) Miklós Tünde Ajzner Éva (1968-) (laboratóriumi szakorvos) Muszbek László (1942-) (haematológus, kutató orvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00050
GINOP
K113097
OTKA
K116228
OTKA
K120633
OTKA
MTA 11003 TKI417
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM066248
035-os BibID:(WoS)000391287100018 (Scopus)84995700032
Első szerző:Mezei Zoltán András (orvos)
Cím:Regulation of plasma factor XIII levels in healthy individuals; a major impact by subunit B intron K c.1952+144 C>G polymorphism / Zoltán A. Mezei, Éva Katona, Judit Kállai, Zsuzsanna Bereczky, Éva Molnár, Bettina Kovács, Éva Ajzner, Zsuzsa Bagoly, Tünde Miklós, László Muszbek
Dátum:2016
ISSN:0049-3848
Megjegyzések:BackgroundThe regulation of plasma factor XIII (FXIII) levels in healthy individuals has been only partially explored. The identification of major non-genetic and genetic regulatory factors might provide important information on the contribution of FXIII to the risk of cardio/cerebrovascular diseases.ObjectivesTo determine the effect of age, smoking, BMI, fibrinogen concentration on plasma FXIII activity, complex FXIII antigen (FXIII-A2B2) and total FXIII-B subunit (tFXIII-B) level, to correlate FXIII-B level with the other two FXIII parameters and to assess the variation of FXIII levels in carriers of major FXIII subunit polymorphisms.Methods268 healthy individuals were enrolled in the study. FXIII activity was measured by the ammonia release assay; FXIII-A2B2 and tFXIII-B were determined by ELISAs. FXIII-A p.Val34Leu, FXIII-B p.His95Arg and FXIII-B intron K c.1952 + 144 C > G polymorphisms were identified by RT-PCR using melting point analysis with fluorescence resonance energy transfer detection.ResultsAll investigated FXIII parameters showed significant positive correlation with age and fibrinogen level; gender and BMI influenced only tFXIII-B. A highly significant positive correlation was demonstrated between tFXIII-B and the other FXIII parameters. FXIII-A p.Val34Leu polymorphism had only slight, if any effect on FXIII levels. The FXIII-B Arg95 allele moderately increased all three FXIII parameters, but the effect became statistically significant only after adjustment. The FXIII-B intron K G allele drastically decreased FXIII levels, and it seemed to be in synergism with the FXIII-A Leu34 allele.ConclusionsPlasma FXIII levels are subjected to multifactorial regulation, in which age, fibrinogen level and FXIII-B intron K polymorphism are major determinants.AbbreviationsBMI, body mass index; FXIII, plasma factor XIII; FXIIIa, activated FXIII; FXIII-A, FXIII A subunit; FXIII-B, FXIII B subunit; tFXIII-B, total FXIII-B subunit.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Factor XIII
Fibrinogen
Gender
Healthy volunteers
Polymorphism
Megjelenés:Thrombosis Research. - 148 (2016), p. 101-106. -
További szerzők:Katona Éva (1961-) (klinikai biokémikus) Kállai Judit (1983-) (molekuláris biológus) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Molnár Éva (1977-) (analitikus) Kovács Bettina (1975-) (orvos) Ajzner Éva (1968-) (laboratóriumi szakorvos) Bagoly Zsuzsa (1978-) (orvos) Miklós Tünde Muszbek László (1942-) (haematológus, kutató orvos)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1