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001-es BibID:BIBFORM049534
Első szerző:Kõrv, Janika
Cím:Benefit of thrombolysis for stroke is maintained around the clock : results from the SITS-EAST Registry / J. Kõrv, R. Vibo, P. Kadlecová, A. Kobayashi, A. Czlonkowska, M. Brozman, V. Švigelj, L. Csiba, K. Fekete, V. Demarin, A. Vilionskis, D. Jatuzis, Y. Krespi, N. Ahmed, R. Mikulík, the Safe Implementation of Treatments in Stroke - East (SITS-EAST) Registry Investigators
Dátum:2014
ISSN:1351-5101
Megjegyzések:Background and purpose: The outcome of thrombolysis for early morning and sleeptime strokes may be worse because of uncertainty of stroke onset time or differencesin logistics. The aim of the study was to analyze if stroke outcome after intravenousthrombolysis differs depending on time of day when the stroke occurs.Methods: The data collected in the Safe Implementation of Treatments in Stroke Eastern Europe (SITS-EAST) Registry between September 2000 and December2011 were used. Strokes were categorized as night-time 00:00?07:59, day-time08:00?15:59 and evening-time 16:00?23:59 and were compared in terms of severaloutcome measures. All results were adjusted for baseline differences.Results: A total of 8878 patients were enrolled: 18% had night-time, 54% day-timeand 28% evening-time strokes. Onset-to-treatment time in patients with night-timestrokes was 10 min longer than in day-time and evening-time strokes (P < 0.001).Symptomatic intracerebral hemorrhage by ECASS II definition occurred in 5.6%,5.6% and 5.3% (adjusted P = 0.41) of the night-time, day-time and evening-timestroke patients, respectively; by SITS definition it occurred in 2.5%, 1.9% and 1.3%(adjusted P = 0.013) and by NINDS definition in 7.8%, 7.6% and 7.5% (adjustedP = 0.74). Patients with night-time, day-time and evening-time strokes achievedmodified Rankin Scale score 0?1 in 33%, 31%, 31% (adjusted P = 0.34) and 0?2 in52%, 51%, 50% (adjusted P = 0.23), and 13%, 15%, 16% respectively of patientsdied (adjusted P = 0.17) by 3 months.Conclusions: The time when stroke occurs (day versus evening versus night) doesnot affect the outcome after thrombolysis despite the fact that patients with nighttimestrokes have worse time management.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
circadian variation
mRS
NIHSS
outcome
SITS
stroke
symptomatic intracerebral haemorrhage
trhombolysis
Megjelenés:European Journal of Neurology 21 : 1 (2014), p. 112-117. -
További szerzők:Vibo, R. Kadlecova, Pavla Kobayashi, Anna Czlonkowska, A. Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Ahmed, Niaz Mikulík, Robert The Safe Implementation of Treatments in Stroke - East (SITS-EAST) Registry Investigators
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2.

001-es BibID:BIBFORM042545
Első szerző:Mikulík, Robert
Cím:Factors influencing in-hospital delay in treatment with intravenous thrombolysis / Robert Mikulík, Pavla Kadlecova, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Victor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Niaz Ahmed
Dátum:2012
ISSN:0039-2499
Megjegyzések:Background: Shortening door-to-needle time (DNT) for the thrombolytic treatment of strokecan improve treatment efficacy by reducing onset-to-treatment time. The goal of our studywas to explore the association between DNT and outcome and to identify factors influencingDNT to better understand why some patients are treated late.Methods: Prospectively collected data from the Safe Implementation of Treatments in Stroke-East registry (SITS-EAST: nine Central and Eastern European countries) on all patientstreated with thrombolysis between February/2003 and February/2010 were analyzed. Multiplelogistic regression analysis was used to identify predictors of DNT?60 minutes.Results: Altogether, 5563 patients were treated with thrombolysis within 4.5 hours ofsymptom onset. Of these, 2097 (38%) had DNT?60 minutes. In different centers, theproportion of patients treated with DNT?60 minutes ranged from 18 to 84% (p<0.0001).Patients with longer DNT (in 60 minute increments) had less chance of achieving modifiedRankin scale 0-1 at 3 month (adjusted OR 0.86, 95%CI 0.77 to 0.97). DNT?60 minutes wasindependently predicted by younger age (in 10 year increments, OR 0.92, 95%CI 0.87 to0.97), NIHSS score 7-24 (OR 1.44, 95%CI 1.2 to 1.7), onset-to-door time (in 10 minuteincrements, OR 1.19, 95%CI 1.17 to 1.22), treatment center (p<0.001), and country(p<0.001).Conclusions: Thrombolysis of patients with older age and mild or severe neurological deficitis delayed. The perception that there is sufficient time before the end of thrombolytic windowalso delays treatment. It is necessary to improve adherence to guidelines and to treat patientssooner after arrival to hospital.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Stroke. - 43 : 6 (2012), p. 1578-1583. -
További szerzők:Kadlecova, Pavla Czlonkowska, Anna Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Ahmed, Niaz
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3.

001-es BibID:BIBFORM079833
Első szerző:Neumann J.
Cím:Diabetes mellitus and previous ischemic stroke in stroke thrombolysis : analysis of sitseast registry data / J. Neumann ,P. Kadlecová, A. Tomek, A. Kobayashi, Z. Gdovinova, V. Svigelj, K. Fekete, J. Kõrv, D. Jatuzis, R. Mikulík
Dátum:2016
Megjegyzések:Background: The European drug license for alteplase and current recommendations for ischemic stroke excludes from intravenous thrombolysis (IVT) patients with diabetes mellitus and previous ischemic stroke (DM ? pIS positive). Our aim was to evaluate safety and effectiveness of IVT in stroke patients with diabetes mellitus and previous ischemic stroke. Methods: We analyzed the data from the register SITSEAST between January 2002 and August 2013. DM ? pIS positive and DM ? pIS negative groups of patients were compared with respect to safety (symptomatic intracerebral hemorrhage [sICH]) and efficacy (modified Rankin scale [mRS]). Adjustment for baseline difference was performed with general estimating equation. Results: Of 12888 patients treated with IVT, 465 (4%) had DM ? pIS. DM ? pIS positive group had more severe ischemic stroke (median NIHS score 12 versus 11) and less frequently prestroke mRS 0?1 (70% versus 89%, P < 0,001) as compared to DM ? pIS negative patients. DM ? pIS positive patients had significantly lower adjusted odds to achieve mRS 0?1 (OR 0.69; 95% CI: 0.51?0.94) but not functional independence at 3 months (mRS 0?2, OR 0.75; 95% CI: 0.48?1.17). Adjusted odds for death (OR 1.32; 95% CI: 0.96?1.82) or disability was not significantly increased. No association between sICH and DM ? pIS was found (e.g. for MOST definition of ICH, OR was 1.73; 95% CI: 0.88?3.39). Conclusions: Patients with diabetes mellitus and previous ischemic stroke do not have increased risk of SICH, death or disability, but achieve less favorable outcome. Patients with diabetes mellitus and previous ischemic stroke should not be excluded from thrombolytic treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
stroke
Megjelenés:European Stroke Journal. - 1 : Suppl. 1 (2016), p. 591. -
További szerzők:Kadlecova, Pavla Tomek, A. Kobayashi, Anna Gdovinova, Zuzana Švigelj, Victor Fekete Klára (1978-) (neurológus) Kõrv, Janika Jatuzis, Dalius Mikulík, Robert
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4.

001-es BibID:BIBFORM091004
Első szerző:Tsivgoulis, Georgios
Cím:Intravenous thrombolysis for ischemic stroke in the golden hour : propensity-matched analysis from the SITS-EAST registry / Georgios Tsivgoulis, Aristeidis H. Katsanos, Pavla Kadlecova, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Körv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Chrissoula Liantinioti, Sotirios Giannopoulos, Robert Mikulik
Dátum:2017
ISSN:0340-5354
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Neurology. - 264 : 5 (2017), p. 912-920. -
További szerzők:Katsanos, Aristeidis H. Kadlecova, Pavla Czlonkowska, Anna Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Körv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Liantinioti, Chrissoula Giannopoulos, Sotirios Mikulík, Robert
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5.

001-es BibID:BIBFORM079857
035-os BibID:(cikkazonosító)AS08-015
Első szerző:Tsivgoulis, Georgios
Cím:Intravenous thrombolysis for patients with in-hospital stroke onset : propensity-matched analysis from the SITS-EAST registry / G. Tsivgoulis, A. H. Katsanos, P. Kadlecova, A. Czlonkowska, A. Kobayashi, M. Brozman, V. Švigelj, L. Csiba, K. Fekete, J. Kõrv, V. Demarin, A. Vilionskis, D. Jatuzis, Y. Krespi, C. Liantinioti, S. Giannopoulos, R. Mikulik
Dátum:2017
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
stroke
Megjelenés:European Stroke Journal. - 2 : Suppl. 1 (2017), p. 71. -
További szerzők:Katsanos, Aristeidis H. Kadlecova, Pavla Czlonkowska, A. Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin V. Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Liantinioti, Chrissoula Giannopoulos, Sotirios Mikulík, Robert
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6.

001-es BibID:BIBFORM071091
035-os BibID:(WoS)000415723800016 (Scopus)85034075239
Első szerző:Tsivgoulis, Georgios
Cím:Intravenous thrombolysis for patients with in-hospital stroke onset : propensity-matched analysis from the Safe Implementation of Treatments in Stroke-East registry / Georgios Tsivgoulis, Aristeidis H. Katsanos, Pavla Kadlecová, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Theodore Karapanayiotides, Sotirios Giannopoulos, Robert Mikulik
Dátum:2017
ISSN:1351-5101
Megjegyzések:Introduction: Recent cross-sectional study data suggest that intravenous thrombolysis (IVT) in patients with in-hospital (IHS) acute ischemic stroke (AIS) onset is associated with unfavourable functional outcomes at hospital discharge and in-hospital mortality compared to patients with outof-hospital stroke onset (OHS) treated with IVT. We sought to compare outcomes between IVT treated IHS and OHS patients by analysing propensity score matched (PSM) data from the SITSEAST registry. Methods: We compared the following outcomes for all PSM patients: 1.symptomatic intracranial hemorrhage (sICH) defined with the SITS-MOST criteria, 2.favourable functional outcome Accepted ArticleThis article is protected by copyright. All rights reserved. (FFO) defined as a modified Rankin Scale (mRS) score of 0-1 at three months, 3.Functional independence (FI) defined as a mRS score of 0-2 at three months, 4.3-month mortality. Results: Out of total 19,077 IVT-treated AIS patients, 196 IHS patients were matched to 5124 OHS patients, with no differences in all baseline characteristics (p>0.1). IHS had longer door-to-needle [90 min (60-140) vs. 65 (47-95), p<0.001] and door-to-imaging times [40 min (20-90) vs 24 (15-35), p<0.001] compared to OHS. No differences were detected in the rates of sICH (1.6% vs 1.9%, p=0.756), FFO (46.4% vs 42.3%, p=0.257), FI (60.7% vs. 60.0%,p=0.447) and mortality (14.3% vs 15.1%,p=0.764). The distribution of 3-month mRS-scores was similar in the two groups (p=0.273). Conclusions: Our findings underline the safety and efficacy of IVT for IHS. They also underscore the potential of reducing in-hospital delays for timely tPA delivery in patients with IHS.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
intravenous thrombolysis
acute ischemic stroke
in-hospital stroke
onset-to-treatment time
door-to-needle time
stroke awareness
Megjelenés:European Journal of Neurology. - 24 : 12 (2017), p. 1493-1498. -
További szerzők:Katsanos, Aristeidis H. Kadlecova, Pavla Czlonkowska, Anna Kobayashi, Adam Brozman, Miroslav Švigelj, Victor Csiba László (1952-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Kõrv, Janika Demarin, Vida Vilionskis, Aleksandras Jatuzis, Dalius Krespi, Yakup Karapanayiotides, Theodore Giannopoulos, Sotirios Mikulík, Robert
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