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001-es BibID:BIBFORM079833
Első szerző:Neumann J.
Cím:Diabetes mellitus and previous ischemic stroke in stroke thrombolysis : analysis of sitseast registry data / J. Neumann ,P. Kadlecová, A. Tomek, A. Kobayashi, Z. Gdovinova, V. Svigelj, K. Fekete, J. Kõrv, D. Jatuzis, R. Mikulík
Dátum:2016
Megjegyzések:Background: The European drug license for alteplase and current recommendations for ischemic stroke excludes from intravenous thrombolysis (IVT) patients with diabetes mellitus and previous ischemic stroke (DM ? pIS positive). Our aim was to evaluate safety and effectiveness of IVT in stroke patients with diabetes mellitus and previous ischemic stroke. Methods: We analyzed the data from the register SITSEAST between January 2002 and August 2013. DM ? pIS positive and DM ? pIS negative groups of patients were compared with respect to safety (symptomatic intracerebral hemorrhage [sICH]) and efficacy (modified Rankin scale [mRS]). Adjustment for baseline difference was performed with general estimating equation. Results: Of 12888 patients treated with IVT, 465 (4%) had DM ? pIS. DM ? pIS positive group had more severe ischemic stroke (median NIHS score 12 versus 11) and less frequently prestroke mRS 0?1 (70% versus 89%, P < 0,001) as compared to DM ? pIS negative patients. DM ? pIS positive patients had significantly lower adjusted odds to achieve mRS 0?1 (OR 0.69; 95% CI: 0.51?0.94) but not functional independence at 3 months (mRS 0?2, OR 0.75; 95% CI: 0.48?1.17). Adjusted odds for death (OR 1.32; 95% CI: 0.96?1.82) or disability was not significantly increased. No association between sICH and DM ? pIS was found (e.g. for MOST definition of ICH, OR was 1.73; 95% CI: 0.88?3.39). Conclusions: Patients with diabetes mellitus and previous ischemic stroke do not have increased risk of SICH, death or disability, but achieve less favorable outcome. Patients with diabetes mellitus and previous ischemic stroke should not be excluded from thrombolytic treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
stroke
Megjelenés:European Stroke Journal. - 1 : Suppl. 1 (2016), p. 591. -
További szerzők:Kadlecova, Pavla Tomek, A. Kobayashi, Anna Gdovinova, Zuzana Švigelj, Victor Fekete Klára (1978-) (neurológus) Kõrv, Janika Jatuzis, Dalius Mikulík, Robert
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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