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1.

001-es BibID:BIBFORM092841
035-os BibID:(cikkazonosító)615177
Első szerző:Árokszállási Tamás (neurológus)
Cím:Prognostic value of various hemostasis parameters and neurophysiological examinations in spontaneous intracerebral hemorrhage : the IRONHEART study protocol / Tamás Árokszállási, Máté Héja, Zsuzsa Bagoly, Kitti Bernadett Kovács, Rita Kálmándi, Ferenc Sarkady, Judit Tóth, Klára Fekete, István Fekete, Laszlo Csiba
Dátum:2021
ISSN:1664-2295
Megjegyzések:Rationale: Stroke is the leading cause of death in all developed countries. In Hungary, more than 10000 patients die annually due to cerebrovascular diseases according to the WHO Mortality Database. 10-15 % of these patients suffer non-traumatic intracerebral hemorrhage (ICH). ICH results in a higher rate of mortality as compared to ischemic stroke and outcomes are difficult to predict. In the GINOP IRONHEART study, we aim to test various hemostasis parameters and clinical neurophysiological examinations in evaluating outcome in intracerebral haemorrhage. Methods: In this prospective, observational study, we plan to enroll consecutive patients with non-traumatic spontaneous intracerebral hemorrhage admitted to a single Stroke Center (Department of Neurology, University of Debrecen, Hungary). The protocol of the GINOP IRONHEART study includes the investigation of detailed clinical, laboratory investigations, and various neurophysiological examiniations. Stroke severity is quantified based on the National Institutes of Health Stroke Scale (NIHSS) on admisson and day 7, 14, 90 after the onset of stroke. Cranial CT is performed on admission, day 14, and 90 to estimate the ICH volume. Modified Rankin Score (mRS) is used for evaluating the long-term outcome (90 days post-event). Blood is drawn immediately on admission for specific hemostasis tests. Digital and quantitative EEG techniques and motor evoked potential (MEP) are performed to evaluate the prognosis of cerebral hemorrhage on admission (within 24-28h), immediately before discharge (??10?14 days later), and 3 months after the event. Outcomes: The following outcomes are investigated: 1/ Mortality by day 14 and day 90 2/ Long-term outcome at 90 days post-event: mRS 0-1 is defined as favorable long-term outcome. Discussion: If associations between outcomes and the investigated parameters (hemostasis and neurophysiological examinations) are confirmed, results might aid prognosis assessment in this subtype of stroke with particularly high mortality. Improving clinical grading systems on ICH severity and outcomes by including the investigated parameters could help to better guide the management of these patients in the future.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 12 (2021), p. 1-6. -
További szerzők:Héja Máté (1991-) (általános orvos) Bagoly Zsuzsa (1978-) (orvos) Kovács Kitti Bernadett (1985-) (neurológus) Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Sarkady Ferenc (1982-) (laboratóriumi analitikus) Tóth Judit (1964-) (radiológus) Fekete Klára (1978-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
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2.

001-es BibID:BIBFORM079827
035-os BibID:(cikkazonosító)AS24-060
Első szerző:Árokszállási Tamás (neurológus)
Cím:Hemostasis biomarkers in the prognosis of non-traumatic intracerebral hemorrhage / T. Arokszallasi, Z. Bagoly, K. Fekete, I. Fekete, I. Szegedi, M. Andrejkovics, J. Toth, L. Csiba
Dátum:2019
Megjegyzések:Background and Aims: Non-traumatic intracerebral hemorrhage (ICH) accounts for 10?15% of all strokes and results in higher rate of mortality as compared to ischemic strokes. In the IRONHEART study we aimed to find potential hemostasis biomarkers with prognostic value in patients with ICH. Methods: In this prospective, observational study, 183 acute stroke patients and 140 healthy controls were included. Patients were grouped: 51 primary ICH patients (PICH), 118 acute ischemic stroke patients who underwent thrombolysis without hemorrhagic events (AIS), 13 patients with AIS who suffered hemorrhagic complications after intravenous thrombolysis (AIS-ICH). On admission, CT angiography, detailed clinical and laboratory investigations were performed. The following hemostasis measurements were carried out from blood samples: hemostasis screening tests, von Willebrand factor (VWF) antigen, factor XIII (FXIII), plasminogen and a2 antiplasmin activity, D-dimer. Patients were followed for 90 days, long term outcomes were defined using the modified Rankin Scale. Results: VWF level was significantly higher in all patient groups as compared to controls. VWF levels were significantly higher in patients with worse long-term outcomes (mRS>3) in all patient cohorts. FXIII activity was significantly elevated in the PICH group as compared to controls and to both AIS groups. FXIII activity in the lowest quartile was associated with a significant risk of mortality in the PICH group (OR: 9.9; 95%CI:1.6- 61.6, p ? 0.015). Among fibrinolytic markers, only D-dimer showed association with worse long-term outcomes (mRS>3). Conclusions: VWF antigen, FXIII activity and D-dimer could serve as biomarkers of long-term outcomes in PICH patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
haemorrhage
Megjelenés:European Stroke Journal. - 4 : Suppl. 1 (2019), p. 449. -
További szerzők:Bagoly Zsuzsa (1978-) (orvos) Fekete Klára (1978-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Szegedi István (1992-) (orvos) Andrejkovics Mónika (1967-) (klinikai szakpszichológus, neuropszichológus, pszichoterapeuta) Tóth J. Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
NKFI-K120042
NKFI
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3.

001-es BibID:BIBFORM076872
Első szerző:Árokszállási Tamás (neurológus)
Cím:Acute alcohol intoxication may cause delay in stroke treatment : case reports / ATamas Arokszallasi, Eszter Balogh, Laszlo Csiba, Istvan Fekete, Klara Fekete, Laszlo Olah
Dátum:2019
ISSN:1471-2377
Megjegyzések:Background:The signs and symptoms of acute alcohol intoxication resemble those of vertebrobasilar stroke. Dueto their shared symptoms including double vision, nystagmus, dysarthria, and ataxia, the differential diagnosis ofalcohol intoxication and vertebrobasilar stroke may pose a challenge. Moreover, if alcohol intoxication and strokeoccur simultaneously, the signs and symptoms of stroke may be attributed to the effects of alcohol, leading todelayed stroke diagnosis and failure to perform reperfusion therapy.Case presentations:Three cases of alcohol intoxication and stroke are presented. The first patient (female, 50 yearsold) had dysarthria, nystagmus and trunk ataxia on admission. Her blood alcohol level was 2.3?.The symptomsimproved after forced diuresis, but 5.5 h later progression was observed, and the patient developed diplopia anddysphagia in addition to her initial symptoms. Angiography showed occlusion of the basilar artery. Intraarterialthrombolysis was performed. The second patient (male, 62 years old) developed diplopia, dysarthria and trunkataxia after consuming 4-units of alcohol, and his symptoms were attributed to alcohol intoxication. Two hourslater, neurological examination revealed dysphagia and mild right-sided hemiparesis, which questioned the causalrelationship between the symptoms and alcohol consumption. Cerebral CT was negative, and intravenousthrombolysis was administered. The third patient (male, 55 years old) consumed 10 units of alcohol before fallingasleep. Three hours later, his relatives tried to wake him up. He was unresponsive, which was attributed to alcoholintoxication. When he woke up 8 h later, right-sided hemiparesis and aphasia were observed, and cerebral CTalready revealed irreversible ischemic changes.Conclusions:Our cases show that alcohol consumption may interfere with stroke diagnosis by mimicking the signsand symptoms of vertebrobasilar stroke. Moreover, attributing the symptoms of stroke to alcohol intoxication maydelay stroke diagnosis resulting in failure of reperfusion therapy. Based on our observations we conclude that strokeshould be considered in the case of worsening symptoms, dysphagia, hemiparesis and disproportionately severesigns that cannot be attributed to the amount of alcohol consumed. In the case of ambiguity, ambulance shouldbe called, and if stroke cannot be excluded, specific therapy should be administered.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
alcohol intoxication
stroke
thrombolytic therapy
diagnostic errors
Megjelenés:BMC Neurology. - 19 : 1 (2019), p. 1-5. -
További szerzők:Balogh Eszter (1991-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Oláh László (1967-) (neurológus)
Pályázati támogatás:NAP_13-1-2013-0001
Egyéb
2017-1.2.1-NKP-2017-00002
Egyéb
NFKH-K 120042
Egyéb
NFKH-K 109712
Egyéb
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4.

001-es BibID:BIBFORM029951
Első szerző:Bereczki Dániel (neurológus)
Cím:Mannitol use in acute stroke : case fatality at 30 days and 1 year / Bereczki D., Mihálka L., Szatmári S., Fekete K., Di Cesar D., Fülesdi B., Csiba L., Fekete I.
Dátum:2003
ISSN:0039-2499
Megjegyzések:BACKGROUND AND PURPOSE: Mannitol is used worldwide to treat acute stroke, although its efficacy and safety have not been proven by randomized trials.METHODS:In a tricenter, prospective study, we analyzed the 30-day and 1-year case fatality with respect to mannitol treatment status in 805 patients consecutively admitted within 72 hours of stroke onset. Confounding factors were compared between treated and nontreated patients.RESULTS:Two thirds of the patients received intravenous mannitol as part of their routine treatment (mean dose, 47+/-22 g/d; mean duration, 6+/-3 days). The case fatality was 25% versus 16% (P=0.006) at 30 days and 38% versus 25% (P<0.001) at 1 year in the-mannitol treated and nontreated groups, respectively. Mannitol treatment effect was adjusted for age, stroke severity, fever in the first 3 days, and aspirin treatment (for ischemic strokes) in logistic regression models. Depending on the factors entered into the model, either no effect or harm could be attributed to mannitol. When the analysis was restricted to those admitted within 24 hours (n=568), case fatality differed significantly only at 1 year (35% in treated and 26% in nontreated patients, P=0.044). Although the prognostic scores of the Scandinavian Neurological Stroke Scale were similar in treated and nontreated patients, both in ischemic and hemorrhagic strokes, the patient groups differed in several factors that might also have influenced survival.CONCLUSIONS:Based on the results of this study, no recommendations can be made on the use of mannitol in acute stroke, and properly randomized, controlled trials should be performed to come to a final conclusion.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Stroke. - 34 : 7 (2003), p. 1730-1735. -
További szerzők:Mihálka László (1950-) (neurológus) Szatmári Szabolcs (1960-) (neurológus) Fekete Klára (1978-) (neurológus) Di Cesar, D. Fülesdi Béla (1961-) (aneszteziológus) Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter)
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5.

001-es BibID:BIBFORM010568
Első szerző:Bereczki Dániel (neurológus)
Cím:The Debrecen Stroke Database : demographic characteristics, risk factors, stroke severity and outcome in 8088 consecutive hospitalised patients with acute cerebrovascular disease / Bereczki D., Mihalka L., Fekete I., Valikovics A., Csepany T., Fulesdi B., Bajko Z., Szekeres C., Fekete K., Csiba L.
Dátum:2009
Megjegyzések:High stroke mortality in central-eastern European countries might be due to higher stroke incidence, more severe strokes or less effective acute care than in countries with lower mortality rate. Hospital databases usually yield more detailed information on risk factors, stroke severity and short-term outcome than population-based registries. Patients and methods The Debrecen Stroke Database, data of 8088 consecutively hospitalised patients with acute cerebrovascular disease in a single stroke centre in East Hungary between October 1994 and December 2006, is analysed. Risk factors were recorded and stroke severity on admission was scored by the Mathew stroke scale. The modified Glasgow outcome scale was used to describe patient condition at discharge. Results Mean age was 68713 years, 11.4% had haemorrhagic stroke. The rate of hypertension on admission was 79% in men, and 84% in women, 40.3%of men and 19.8%of women were smokers, and 34% of all patients had a previous cerebrovascular disease in their history. Case fatality was 14.9%, and 43% had some disability at discharge. Outcome at discharge was worse with higher age, higher glucose, higher blood pressure, higher white cell count and erythrocyte sedimentation rate and more severe clinical signs on admission. In multivariate analysis admission blood pressure lost its significance in predicting outcome. Conclusions In this large Hungarian stroke unit database hypertension on admission, smoking and previous cerebrovascular disease were more frequent than in most western databases. These findings indicate major opportunities for more efficient stroke prevention in this and probably other eastern European countries.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
acute
blood pressure
cerebral haemorrhage
epidemiology
ischaemic stroke
risk factors
Megjelenés:International Journal of Stroke. - 4 : 5 (2009), p. 335-339. -
További szerzők:Mihálka László (1950-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Valikovics Attila Csépány Tünde (1956-) (neurológus, pszichiáter) Fülesdi Béla (1961-) (aneszteziológus) Bajkó Z. Szekeres C. Fekete Klára (1978-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter)
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6.

001-es BibID:BIBFORM079831
Első szerző:Fekete István (neurológus, pszichiáter)
Cím:Effect of acute stroke on heart function / I. Fekete, N. Deregi, J. Aranyosi, K. Fekete, L. Csiba
Dátum:2010
Megjegyzések:Background: There are contradictory data on how brain hemispheric localization/side influences the function of the heart. Our aim was to study the pathologic cardiological abnormalities in acute stroke patients without coronary heart disease or rhythm disturbances in the anamnesis. Methods: Between 1st of March, 2009 and 30th of September, 2009 at the Neurointensive Care Unit we monitorized 91 acute stroke patients' parameters continuously for 24-36 hours: pulse, systolic, diastolic, mean blood pressure, 12 lead ECG. We were interested in the correlation of the above mentioned parameters and age, side and size of the cerebral lesion (by CT/MRI), type of stroke, mortality. Exclusion criteria were: fever, severe hyperglycemia, cardiac failure, myocardial infarct, pulmonary disorders, obstructive sleep apnoe, drug or metabolic caused rhythm disturbances, beta blocker usage. Results: The average age was 62,3?14,6 years. The left hemisphere was affected in 45%, the right in 38,5%, both hemispheres in 3,3%, and 13,2% suffered from VB syndrome. Ischemic stroke was in 74,7%, hemorrhage 14,3%, SAH 3,3%, TIA 7,7%. In the group where no heart disorder was known at admission, altogether 18% had repolarization abnormalities (10 patients had ST depression, 7 ST elevation). In addition, especially during the night, by 33% of the patients supraventricular (SVES) and ventricular extrasystoles (VES) were detected. 35% of patients had tachycardy and 23% bradycardy, both were significantly higher in the right sided lesions (p<0.05). VES was more frequent in left hemispherical lesions and VB syndrome (p<0.05). Less than 90 mmHg systolic pressure could be detected in 27% of patients, this was remarkable at dawn. Nine patients died, in 2 patients fatal rhythm disturbance caused death. Conclusion: Both sided hemispheric lesions and VB syndromes can cause cardiological and ECG abnormalities. Intensive monitoring is essential in acute stroke at least for 36 hours.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Cerebrovascular Diseases. - 29 : Suppl. 2 (2010), p. 157. -
További szerzők:Deregi N. Aranyosi János (1963-) (szülész-nőgyógyász) ifj. Fekete Klára (1978-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter)
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7.

001-es BibID:BIBFORM096522
035-os BibID:(cikkazonosító)757078 (WoS)000717640900001 (Scopus)85118804752
Első szerző:Fekete Klára (neurológus)
Cím:Neurophysiological examinations as adjunctive tool to imaging techniques in spontaneous intracerebral haemorrhage : IRONHEART study / Fekete Klára, Tóth Judit, Horváth László, Márton Sándor, Héja Máté, Csiba László, Árokszállási Tamás, Bagoly Zsuzsa, Sulina Dóra, Fekete István
Dátum:2021
ISSN:1664-2295
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 12 (2021), p. 1-15. -
További szerzők:Tóth Judit (1964-) (radiológus) Horváth László (1973-) (gyógyszerész) Márton Sándor (1965-) (matematikus) Héja Máté (1991-) (általános orvos) Csiba László (1952-) (neurológus, pszichiáter) Árokszállási Tamás (1988-) (neurológus) Bagoly Zsuzsa (1978-) (orvos) Sulina Dóra (PhD hallgató) Fekete István (1951-) (neurológus, pszichiáter)
Pályázati támogatás:K109712
OTKA
K120042
OTKA
FK128582
OTKA
GINOP-2.3.2-15-2016-00043
GINOP
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8.

001-es BibID:BIBFORM079825
Első szerző:Fekete Klára (neurológus)
Cím:Experiences with intravenous (IV) and intraarterial (IA) thrombolysis in Debrecen, Hungary, focused on glucose level at admission and patients over 80 / K. Fekete, D. Bereczki, L. Csiba, I. Fekete
Dátum:2010
ISSN:1015-9770
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
stroke
Megjelenés:Cerebrovascular Diseases. - 29 : 2 (2010), p. 1-361. -
További szerzők:Bereczki Dániel (1960-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:DOI
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9.

001-es BibID:BIBFORM079836
Első szerző:Fekete Klára (neurológus)
Cím:Clinical neurophysiological examination as a prognotstic tool in evaluating outcome in intracerebral haemorrhage / Klára Fekete, Dóra Sulina, Tamás Árokszállási, László Csiba, István Fekete
Dátum:2019
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
tms
Megjelenés:Clinical Neurophysiology. - 2019 : Special issue (2019), p. e36. -
További szerzők:Sulina Dóra (PhD hallgató) Árokszállási Tamás (1988-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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10.

001-es BibID:BIBFORM079829
035-os BibID:(cikkazonosító)AS05-056
Első szerző:Fekete Klára (neurológus)
Cím:Predictors of long-term outcome in patients with basilar artery occlusion : a single center study / K. Fekete, J. Toth, H. Mate, M. Sandor, H. Toth, L. Csiba, I. Fekete
Dátum:2019
Megjegyzések:Background and Aims: Basilar artery occlusion (BAO) is a fatal disease despite recanalization techniques and limited data is available of the factors predicting outcome. Methods: Data of 100 patients treated with BAO was collected prospectively between 2004 and 2018. Risk factors, neurological status, outcome (case fatality, 3-months-mRS, one-year-survival); cranial CT (posterior circulation ASPECT score), result of CT angiography; and the treatment modality was given. Results: Average age was 64.9 13.7 years, 54% male. The most remarkable risk factor was previous stroke (29%), 55% of it vertebrobasilar (58% mortality). The onset to treatment time was 4.23 2.85 hours. The pc-ASPECT score was 10 in 67%, 7 points 33%. BAO was in the proximal part in 17%, in half in 20%, total in 21% and only the top in 42%; respectively within its group the mortality was 53%, 45%, 62%, 38%. Intravenous thrombolysis happened in 43%, intraarterial in 27%, combined therapy in 18% and 12% was treated conservatively. Case fatality within the treatment group was respectively: 48.8%, 55.5%, 33.3%, and 66.6% (p ? 0.8). Symptomatic haemorrhage was not different among the recanalization groups (p ? 0.83). Total or partial recanalization was achieved in 39%. There was a favourable trend in the recanalization rate of intraarterial and combined groups (p ? 0.4). At 3 months 23% had mRS 0?2, 3?5 42%, 58% were dead. At one year 26% was alive. Conclusions: The top occlusion of the BA, combined therapy may influence favourably the outcome. Among the risk factors previous VB stroke has a high impact. Trial registration number: N/A
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
haemorrhage
Megjelenés:European Stroke Journal. - 4 : Suppl. 1 (2019), p. 740. -
További szerzők:Tóth Judit (1964-) (radiológus) Máté H. Sándor Mária (1979-) (etnográfus) Tóth H. Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter)
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11.

001-es BibID:BIBFORM079826
Első szerző:Fekete Klára (neurológus)
Cím:Alcohol consumption and smoking are associated with higher 30-day case fatality after stroke in the mures-uzhgorod-debrecen (mud) database / K. E. Fekete, S. Szatmári, I. Szőcs, C. Szekeres, J. Szász, L. Mihálka, V. Smolanka, L. Csiba, D. Bereczki
Dátum:2008
ISSN:1015-9770
Megjegyzések:Abstract Introduction: Age, alcohol consumption, smoking are important risk factors of stroke. After stroke most of the patients suffer from different grade of disability. Methods: In this work the risk factors, mentioned above, the disability and the 30 day case fatality was investigated by analyzing the data of 1047 patients from the MUD database between the 1 st of October 1999 and 30th of September 2000. (The distribution of the patients in the database is the following: 554 patients in Debrecen, 260 patients in Targu Mures and 233 in Uzhgorod). Results: The distribution of stroke concerning the genders by our database is the following: 42,5% female, 57,5 % male. Before discharge 222 patients (22,1%) died. By 172 of the patients (16,4%) occurred stroke in the familial-history. The ratio of the age was found more unfavorable by males: between 30 and 60 years the frequency of stroke was twice as high as by females (on the average by 30,75% of women and 69,26% of men suffer stroke).The ratio is very similar by cerebral bleeding not only ischemia. 249 of total stroke patients admitted alcohol consumption (23,8%), 551 did not (52,6%) (28,6%is unknown). The 30 day mortality rate was 25,3% between the patients admitting alcohol consumption, and only 9,3% between those who did not. In total 339 patients suffered cerebral bleeding ( 32,4%), which is higher then the literary dates. No difference was found between the 3 examination places. The ratio of death in the group of alcohol consumers and alcohol-non-consumer was equally prominently high without any difference. In our database 25,09% of the patients smoked. The excess of disability at dismission was analyzed by 825 patients with the following results: 153 patients (18,5%) needed permanent care, 182 (22%) patients needed help by every-day-life, 230 (27,5%) patients could live a self-sufficient life with residual signs, and 260 (31,5%) had no neurological sign. Results and conclusion: The analysis of the MUD database emphasizes the medical education of the population in health policy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
stroke
Megjelenés:Cerebrovascular Diseases. - 25 : 2 (2008), p. 71. -
További szerzők:Szatmári Szabolcs (1960-) (neurológus) Szőcs Ildikó (1970-) (orvos) Szekeres Csilla Cecília (1980-) (orvos) Szász József (1960-) (neurológus) Mihálka László (1950-) (neurológus) Smolanka, Volodymyr I. (1950-) (orvos) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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12.

001-es BibID:BIBFORM079822
Első szerző:Fekete Klára (neurológus)
Cím:Effectiveness and outcome of intravenous (IV) and intra-arterial (IA) thrombolysis in the Eastern Hungarian Stroke Center / K. Fekete, I. Fekete, D. Bereczki, T. Magyar, L. Olah, T. Csepany, L. Csiba
Dátum:2009
ISSN:1351-5101
Megjegyzések:Introduction: IV and IA thrombolysis is an effective treatment in acute ischemic stroke. Effectiveness and side effects were tested in the database. Methods: We treated 208 patients with IV/IA (145/63 pts) rt-PA after onset of ischemic stroke. After urgent CT, CTA we administered 0.9 mg/kg rt-PA according to the protocol. At local thrombolysis after 5 mg rt-PA bolus, 1 mg/min infusionwasadministered.GCS,NIHSSwereexaminedon the admission and after 7 days, mRS after 3 months. Risk factors and time window of stroke were estimated, too. Results: 64% of patients were male and 36% female.Time window was within 120min by 28% of patients, 180min 44%, 4.5h 17% and more than 270min 11% (for IA thrombolysis)afterstrokeonset.Averageagewas66.5?13.9 and 67.3?14.7 years.The most important risk factors were: hypertension (68.5%), atrial fibrillation (17%), other heart disorders(20%),smoking18.5%),diabetesmellitus(16%), hypercholesterolemia(19%),previousstrokeorTIA(16%). The average of NIHSS before thrombolysis was 14 (2-25), after 24 hours 11 (0-25). Hemorrhagic transformation was 13% after IA, 4.4% after IV administration of rt-PA. Intracerebral haemorrhage was recognized in 17.6% after IA,4.4%IV .Mortalitywas3%within24hours,21%within 3 months (IA: 27.9%, IV:13%). Large artery re-opening after IA thrombolysis was 46%. The proportion of independent patients was 36.4% (mRS) at 3 months. Conclusion: Beside IV thrombolysis IA administration of rt-PA is effective in acute stroke, but ICH and hemorrhagic transformation rate is more frequent
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
thrombolysis
Megjelenés:European Journal of Neurology. - 16 : Suppl. 3 (2009), p. 393. -
További szerzők:Fekete István (1951-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus) Magyar T. Oláh László (1967-) (neurológus) Csépány Tünde (1956-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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