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001-es BibID:	BIBFORM112244
035-os BibID:	(scopus)85133578314 (wos)000822389000001
Első szerző:	Rácz Ágnes (orvos)
Cím:	Heart failure caused by Takayasu`s arteritis in the time of COVID-19 : a case report / Rácz Á. O., Szabó G. T., Erdei N., Győry F., Kolozsvári R. V.
Dátum:	2022
Megjegyzések:	The case of a 35-year-old female with heart failure is presented, where the symptoms overlap with the heterogeneous manifestations of coronavirus disease 2019 (COVID-19). Those similarities and a recent shift in priorities during the SARS-CoV-2 pandemic delayed the recognition of acute heart failure in this patient. During the differential diagnostic process, obliterative disease was discovered in the bilateral subclavian and right renal arteries, and the latter resulted in uncontrolled hypertension, which played a significant role in the development of heart failure. The aetiology of vascular alterations turned out to be Takayasu's arteritis. Diagnosing Takayasu's arteritis is typically not straightforward due to its nonspecific signs and symptoms. Therefore, it can be concluded from our case report that the rising incidence of COVID-19 and focus on ruling out infection can potentially defer alternative, but appropriate diagnostic tests, particularly for certain conditions like rare diseases. Early identification and intervention is especially important for treating acute heart failure, whereas delay increases the risk of severe complications and mortality.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok esettanulmány folyóiratcikk
Megjelenés:	ESC Heart Failure. - 9 : 5 (2022), p. 3602-3607. -
További szerzők:	Szabó Gábor Tamás (1982-) (kardiológus) Erdei Nóra (1979-) (orvos) Győry Ferenc (1969-) (kardiológus) Kolozsvári Rudolf (1976-) (kardiológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM088246
Első szerző:	Szabó Gábor Tamás (kardiológus)
Cím:	Hypothetical dysfunction of the epithelial sodium channel may justify neurohumoral blockade in coronavirus disease 2019 / Szabó Gábor Tamás, Kiss Attila, Csanádi Zoltán, Czuriga Dániel
Dátum:	2021
ISSN:	2055-5822
Megjegyzések:	Since the outbreak of the COVID-19 pandemic, substantial effort has been made to understand the mechanism behind increased mortality in infected patients with pre-existing cardiovascular (CV) conditions. As the angiotensin-converting enzyme 2 (ACE2) on the host cell membrane serves as a known cellular entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the use of renin-angiotensin-aldosterone system (RAAS) inhibitors seemed to pose an increased risk due to the potential upregulation of ACE2. In fact, initial assumptions concerning this issue were proven wrong when data regarding the beneficial effects of these drugs in SARS-CoV-2-infected cardiac patients surfaced. Here, we raise a novel hypothesis on the role of the epithelial sodium channel (ENaC) in the cascade of RAAS-mediated CV regulation in COVID-19 cases. Our assumption is based on the potentially reduced bioavailability of the endoprotease furin, leading to insufficient ENaC activation and consequently, RAAS upregulation. This unique mechanism may, in part, be responsible for the advantages of RAAS inhibition in the treatment of COVID-19 patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk EPITHELIAL SODIUM CHANNEL CORONAVIRUS DISEASE ACE2 COVID-19
Megjelenés:	ESC Heart Failure. - 8 : 1 (2021), p. 171-174. -
További szerzők:	Kiss Attila Csanádi Zoltán (1960-) (kardiológus) Czuriga Dániel (1982-) (kardiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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