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001-es BibID:BIBFORM061981
Első szerző:Klárik Zoltán
Cím:Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion / Zoltan Klarik, Robert Tamas, Eniko Toth, Ferenc Kiss, Eva L. Kovacs, Marta Jäckel, Istvan Furka, Norbert Nemeth
Dátum:2015
ISSN:0102-8650 1678-2674
Megjegyzések:PURPOSE: To examine how the ischemia-reperfusion injury of latissimus dorsi-cutaneous maximus (LDCM) musculocutaneous flap affects the microcirculatory (flap's skin surface) and hemorheological parameters, and whether an intraoperative deterioration would predictively suggest flap failure in the postoperative period. METHODS: Ten healthy male rats were subjected to the study. In Group I the left flap was sutured back after 2-hour, while the contralateral side was right after its elevation. In Group II the same technique was applied, but the pedicle of the left flap was atraumatically clamped for 2-hour. The contralateral side was left intact. On the flap skin surface laser Doppler tissue flowmetry measurements were done before and after and during the protocols applied in the groups. Microcirculatory and hemorheological examinations were done postoperatively. RESULTS: The microcirculatory parameters significantly decreased during immobilization and ischemia. Afterwards, all the regions showed normalization. In the retrospective analysis there was a prominent difference between the microcirculatory parameters of necrotic and survived flap during the early postoperative days (1-3) in Group II. Erythrocyte aggregation and deformability showed only slight differences. CONCLUSIONS: Two-hour ischemia and reperfusion caused deterioration in latissimus dorsi-cutaneous maximus flap microcirculation. Predicting the possible postoperative complication, the intraoperative laser Doppler measurement can be informative.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Microcirculation
Ischemia
Reperfusion
Hemorheology
Rats
Megjelenés:Acta Cirúrgica Brasileira 30 : 8 (2015), p. 551-560. -
További szerzők:Tamás Róbert (sebész, plasztikai sebész) Tóth Enikő Kiss Ferenc (1982-) (kutatóorvos) Kovács Éva L. Jäckel, Marta Furka István (1935-2021) (sebész, urológus, kutatóorvos) Németh Norbert (1975-) (kutatóorvos)
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