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001-es BibID:	BIBFORM109257
035-os BibID:	(Scopus)85149477136 (WoS)000942239000001
Első szerző:	Csernus Brigitta (élelmiszerbiztonsági és -minőségi mérnök)
Cím:	Capsanthin supplementation modulates the immune response in broiler chickens under Escherichia coli lipopolysaccharide challenge / Brigitta Csernus, Csaba Szabó, Renáta Knop, Reda Gebrehaweria Kidane, Sawadi Fransisco Ndunguru, Gabriella Gulyás, Xénia Erika Ozsváth, Levente Czeglédi
Dátum:	2023
ISSN:	2363-9822
Megjegyzések:	Due to the legislation of antibiotic usage, natural substances are required for application in the poultry industry. Because of their potential anti-inflammatory and immunomodulatory effects, carotenoids are great sources. Capsanthin, a major carotenoid giving the red color of pepper, is a promising feed additive, as it can reduce chronic inflammation. This study was conducted to determine the effects of capsanthin supplementation at 80 mg kg?1 in feed on the immune response of broiler chickens under Escherichia coli O55:B5 lipopolysaccharide (LPS) challenge. Ross 308 male broilers were divided into treatments: control (basal diet) and feedsupplemented groups. At 42 d of age, chickens were weighed and then challenged with 1 mg LPS per kilogram of body weight intraperitoneally. Four hours after injection, birds were euthanized, and then spleen and blood samples were collected. Capsanthin supplement at 80 mg kg?1 did not change the growth parameters and the relative spleen weight. LPS immunization resulted in higher splenic interleukin-1? (IL-1?), interleukin-6 (IL-6), and interferon-? (IFN-? ) mRNA expressions. Capsanthin addition reached lower gene expression levels of IL-6 and IFN-? compared to the LPS-injected birds. At plasma level, dietary capsanthin resulted in lower IL-1? and IL-6 levels. These results may indicate the potential anti-inflammatory effect of capsanthin supplementation in broiler chickens.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk capsanthin broiler chicken gene expression immunology
Megjelenés:	Archives Animal Breeding. - 66 : 1 (2023), p. 103-111. -
További szerzők:	Szabó Csaba (1968-) (agrármérnök) Knop Renáta (1983-) (állatorvos) Reda, Gebrehaweria Kidane (Phd hallgató) Ndunguru, Sawadi Fransisco (1980-) Gulyás Gabriella (1985-) (agrár) Ozsváth Xénia Erika Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:	TKP2020-NKA-04 Egyéb ÚNKP20-4-I-DE-101 Egyéb K139021 OTKA
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001-es BibID:	BIBFORM118839
035-os BibID:	(cikkazonosító)4387 (Scopus)85185693265
Első szerző:	Lugata, James Kachungwa (Ph.D hallgató)
Cím:	In ovo feeding of methionine affects antioxidant status and growth-related gene expression of TETRA SL and Hungarian indigenous chicks / James K. Lugata, Sawadi F. Ndunguru, Gebrehaweria K. Reda, Gabriella Gulyás, Renáta Knop, János Oláh, Levente Czeglédi, Csaba Szabó
Dátum:	2024
ISSN:	2045-2322
Megjegyzések:	Methionine (Met) plays a substantial role in poultry due to its involvement in several pathways, including enhancing antioxidant status and improving growth performance and health status. This study examined how in ovo feeding of Met affects hatching performance, antioxidant status, and hepatic gene expression related to growth and immunity in the TETRA-SL LL hybrid (TSL) commercial layer and Hungarian partridge colored hen (HPC) indigenous genotypes. The eggs were injected with saline, DL-Met, and L-Met on 17.5 days of embryonic development. The results showed that the in ovo feeding of DL-Met significantly increased the hatching weight and ferric reducing the ability of the plasma (FRAP) compared with L-Met. The in ovo feeding of either Met source enhanced the liver health and function and hepatic antioxidant status of the chicks. The genotype`s differences were significant; the TSL genotype had better hatching weight, an antioxidant defense system, and downregulated growth-related gene expression than the HPC genotype. In ovo feeding of either Met source enhanced the chicks' health status and antioxidant status, and DL-Met improved the hatching weight of the chicks more than L-Met. Genotype differences were significantly evident in the responses of growth performance, antioxidant status, blood biochemical parameters, and gene expression to Met sources.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 14 : 1 (2024), p. 1-14. -
További szerzők:	Ndunguru, Sawadi Fransisco (1980-) Reda, Gebrehaweria Kidane (Phd hallgató) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Oláh János (1976-) (állattenyésztés) Czeglédi Levente (1977-) (agrármérnök) Szabó Csaba (1968-) (agrármérnök)
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001-es BibID:	BIBFORM118530
035-os BibID:	(WoS)001175647600001 (Scopus)85184758825
Első szerző:	Lugata, James Kachungwa (Ph.D hallgató)
Cím:	Methionine sources and genotype affect embryonic intestinal development, antioxidants, tight junctions, and growth-related gene expression in chickens / James K. Lugata, Sawadi F. Ndunguru, Gebrehaweria K. Reda, Xenia E. Ozsváth, Eszter Angyal, Levente Czegledi, Gabriella Gulyas, Renata Knop, Janos Oláh, Zoltan Mészár, Rita Varga, Brigitta Csernus, Csaba Szabo
Dátum:	2024
ISSN:	2405-6545
Megjegyzések:	Methionine (Met) is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and growth. The present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and health. Fertilized eggs of the two genotypes, TETRA -SL layer hybrid (TSL) d commercial layer hybrid and Hungarian Partridge colored hen breed (HPC) d a native genotype, were randomly distributed into four treatments for each genotype. The treatment groups include the following: 1) control non-injected eggs (NoIn); 2) saline-injected (SaIn); 3) DL-Met injected (DLM); and 4) L-Met injected (LM). The in ovo injection was carried out on 17.5 d of embryonic development; after hatching, eight chicks per group were sacrificed, and the jejunum was extracted for analysis. The results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width, villus height, and villus area (P < 0.05) compared to the control. The DLM group had significantly reduced crypt depth, glutathione content (GSH), glutathione S-transferase 3 alpha (GST3), occludin (OCLN) gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group (P < 0.05). The HPC genotype has overexpressed insulin -like growth factor 1 (IGF1) gene, tricellulin (MD2), occludin (OCLN), superoxide dismutase 1 (SOD1), and GST3 genes than the TSL genotype (P < 0.05). In conclusion, these findings showed that in ovo injection of Met enhanced intestinal development, and function, with genotypes responding differently under normal conditions. Genotypes also influenced the expression of intestinal antioxidants, tight junction, and growth-related genes.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk DL-Methionine L-Methionine In ovo injection Intestinal development Poultry
Megjelenés:	Animal Nutrition. - 16 (2024), p. 218-230. -
További szerzők:	Ndunguru, Sawadi Fransisco (1980-) Reda, Gebrehaweria Kidane (Phd hallgató) Ozsváth Xénia Erika Angyal Eszter Czeglédi Levente (1977-) (agrármérnök) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Oláh János (1976-) (állattenyésztés) Mészár Zoltán Mihály (1977-) (agrármérnök) Varga Rita Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök)
Pályázati támogatás:	K 139021 Egyéb Stipendium Hungaricum Scholarship Egyéb
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001-es BibID:	BIBFORM119806
Első szerző:	Ndunguru, Sawadi Fransisco (1980-)
Cím:	Embryonic methionine triggers post-natal developmental programming in Japanese quail / Ndunguru, Sawadi F.; Reda, Gebrehaweria K.; Csernus, Brigitta; Knop, Renáta; Gulyás, Gabriella; Szabó, Csaba; Czeglédi, Levente; Lendvai, Ádám Z.
Dátum:	2024
ISSN:	0174-1578
Megjegyzések:	Embryonic development is one of the most sensitive and critical stages when maternal effects may influence the offspring's phenotype. In birds and other oviparous species, embryonic development is confined to the eggs, therefore females must deposit resources into the eggs to prepare the offspring for the prevailing post-natal conditions. However, the mechanisms of such phenotypic adjustments remain poorly understood. We simulated a maternal nutritional transfer by injecting 1 mg of l-methionine solution into Japanese quail eggs before the onset of incubation. The increase in early methionine concentration in eggs activated the insulin/insulin-like signalling and mechanistic target of rapamycin (IIS/mTOR) signalling pathways and affected post-natal developmental trajectories. Chicks from methionine-supplemented eggs had higher expression of liver IGF1 and mTOR genes at hatching but were similar in size, and the phenotypic effects of increased growth became apparent only a week later and remained up to three weeks. Circulating levels of insulin-like growth factor-1 (IGF-1) and expression of ribosomal protein serine 6 kinase 1 (RPS6K1), the mTOR downstream effector, were elevated only three weeks after hatching. These results show that specific nutritional cues may have phenotypic programming effects by sequentially activating specific nutrient-sensing pathways and achieving transgenerational phenotypic plasticity.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk L-methionine IGF1 mTOR Growth Amino acid
Megjelenés:	Journal Of Comparative Physiology B-Biochemical Systemic And Environmental Physiology. - Epub (2024), p. 1-11. -
További szerzők:	Reda, Gebrehaweria Kidane (Phd hallgató) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Gulyás Gabriella (1985-) (agrár) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:	K139021 OTKA
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