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001-es BibID:	BIBFORM109285
035-os BibID:	(cikkazonosító)114234 (Scopus)85149209494 (WoS)000962560900001
Első szerző:	Mahr, Katharina
Cím:	Biocompatible polymeric microparticles serve as novel and reliable vehicles for exogenous hormone manipulations in passerines / Katharina Mahr, Maria Anzengruber, Anna Hellerschmid, Julia Slezacek, Herbert Hoi, Guruprakash Subbiahdoss, Franz Gabor, Ádám Z. Lendvai
Dátum:	2023
ISSN:	0016-6480
Megjegyzések:	The administration of exogenous hormones emerged as an essential tool for field studies in endocrinology. However, working with wild animals remains challenging, because under field conditions not every available method meets the necessary requirements. Achieving a sustained elevation in hormone levels, while simultaneously minimising handling time and invasiveness of the procedure is a difficult task in field endocrinology. Facing this challenge, we have investigated the suitability of biocompatible polymeric microparticles, a novel method for drug-administration, as a tool to manipulate hormones in small songbirds. We chose the insulin-like growth factor-1 (IGF-1) as target hormone, because it receives great interest from the research community due to its important role in shaping life-history traits. Moreover, its short half-life and hydrophilic properties imply a major challenge in finding a suitable method to achieve a sustained, systemic long-term release. To study the release kinetics, we injected either IGF-1 loaded polylactic-co-glycolic acid (PLGA) microparticles or dispersion medium (control group) in the skin pocket of the interscapular region of captive bearded reedlings (Panurus biarmicus). We collected blood samples for 7 consecutive days plus an additional sampling period after two weeks and complemented these with an in vitro experiment. Our results show that in vitro, PLGA microparticles allowed a stable IGF-1 release for more than 15 days, following a burst release at the beginning of the measurement. In vivo, the initial burst was followed by a drop to still elevated levels in circulating IGF-1 until the effect vanished by 16 days post-treatment. This study is the first to describe the use of PLGA-microparticles as a novel tool for exogenous hormone administration in a small passerine. We suggest that this method is highly suitable to achieve the systemic long-term release of hydrophilic hormones with short half-life and reduces overall handling time, as it requires only one subcutaneous injection.
Tárgyszavak:	Természettudományok Biológiai tudományok esettanulmány folyóiratcikk
Megjelenés:	General And Comparative Endocrinology. - 336 (2023), p. 1-9. -
További szerzők:	Anzengruber, Maria Hellerschmid, Anna Slezacek, Julia Hoi, Herbert Subbiahdoss, Guruprakash Gabor, Franz Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:	K139021 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103262
035-os BibID:	(cikkazonosító)39 (WOS)000521053300003 (Scopus)85081599279
Első szerző:	Mahr, Katharina
Cím:	Insulin-like growth factor 1 is related to the expression of plumage traits in a passerine species / Katharina Mahr, Orsolya Vincze, Zsófia Tóth, Herbert Hoi, Ádám Z. Lendvai
Dátum:	2020
ISSN:	0340-5443
Megjegyzések:	Avian plumage colors and ornaments are excellent models to study the endocrine mechanisms linking sexually selected traits and individual parameters of quality and condition. Insulin-like growth factor 1 (IGF-1) is an evolutionarily highly conserved peptide hormone. Its regulatory role in cell proliferation and differentiation and its high sensitivity to the nutritional state of individuals suggest it as an interesting candidate, possibly providing a link between body condition and individual capacity to grow elaborated ornamental features. We investigated whether IGF-1 levels during molting correlate with the expression of multiple ornaments in a sexually dichromatic passerine species, the bearded reedling (Panurus biarmicus). We collected blood samples of males and females shortly before the molting completed and measured the size and colors of ornamental traits. Our results indicate that in males, structural plumage colors, the size of the melanin-based ornament (beard), and tail length are independent traits. IGF-1 levels are associated with the length of the tail and the expression of male structural plumage components (UV coloration), but not the melanin-based ornament. In females, plumage color and tail length were independent traits, which were not related to IGF-1 levels. To the best of our knowledge, this study provides the first evidence that IGF-1 could play a role in the development of secondary sexual characters in a bird species.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Plumage coloration Sexual selection Physiology IGF-1 Condition
Megjelenés:	Behavioral Ecology and Sociobiology. - 74 : 3 (2020), p. 1-12. -
További szerzők:	Vincze Orsolya (1988-) (biológus) Tóth Zsófia (1991-) (biológus) Hoi, Herbert Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:	K 113108 OTKA EFOP-3.6.1-16-2016-00022 EFOP TET 15-1-2016-0044 Egyéb MÁEÖ2016_15/76740 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM102031
035-os BibID:	(WoS)000516878400009 (Scopus)85071682192
Első szerző:	Szöllősi Eszter
Cím:	Extremely low malaria prevalence in a wetland specialist passerine / Eszter Szöllősi, Zsófia Tóth, Katharina Mahr, Herbert Hoi, Ádám Z. Lendvai
Dátum:	2019
ISSN:	0031-1820
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Parasitology. - 147 : 1 (2019), p. 87-95. -
További szerzők:	Tóth Zsófia (1991-) (biológus) Mahr, Katharina Hoi, Herbert Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:	K113108 OTKA TÉT 15-1-2016-0044 Egyéb EFOP-3.6.1-16-2016-00022 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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