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001-es BibID:	BIBFORM024293
Első szerző:	Barkai László (gyermekgyógyász)
Cím:	Cardiovascular autonomic dysfunction in diabetes mellitus / Barkai L., Madacsy L.
Dátum:	1995
Megjegyzések:	The aim was to assess cardiovascular autonomic dysfunction in children and adolescents with diabetes mellitus. A total of 110 children and adolescents with type 1 (insulin dependent) diabetes (aged 6 to 18 years) and 130 non-diabetic controls were studied. Resting heart rate, heart rate variation to deep breathing, heart rate response to standing from a lying position, fall in systolic blood pressure on standing, and rise in diastolic blood pressure during sustained handgrip were measured. A reference range of results was obtained in the controls. Diabetic children had significantly increased resting heart rate [92.4 (SEM 2.5) v 84.2 (2.2) beats/min], decreased deep breathing heart rate variation [25.3 (0.9) v 32.8 (0.6) beats/min], and lower standing/lying heart rate ratio [1.23 (0.04) v 1.31 (0.03)] compared with controls. 46 diabetic children (42%) had at least one abnormal autonomic test result. Of these, 20 (15%) had only one abnormal test and 26 (24%) had two or more abnormal tests. Using multiple logistic regression analysis, longer diabetes duration and worse long term metabolic control were independently predictive of cardiovascular autonomic dysfunction as the dependent variable [adjusted OR (95% CI): 2.9 (1.1-5.9) and 3.3 (1.2-6.4), respectively]. Cardiovascular autonomic dysfunction is not rare in children with diabetes. Efforts should be made to maintain the best metabolic control to prevent or delay these complications.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Time Factors Regression Analysis Posture Male Humans Hemoglobin A, Glycosylated Heart Rate Female Diabetic Neuropathies Diabetes Mellitus, Type 1 Child Cardiovascular Diseases Blood Pressure Autonomic Nervous System Diseases Adolescent systolic blood pressure school child priority journal major clinical study insulin dependent diabetes mellitus human disease severity disease duration diastolic blood pressure diabetes control controlled study cardiovascular function autonomic dysfunction ARTICLE INSULIN diabetes mellitus CHILDREN
Megjelenés:	Archives of Disease in Childhood. - 73 : 6 (1995), p. 515-518. -
További szerzők:	Madácsy László (Szeged)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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001-es BibID:	BIBFORM024408
Első szerző:	Barkai László (gyermekgyógyász)
Cím:	Autonomic dysfunction and severe hypoglycaemia in insulin dependent diabetes mellitus / L. Barkai, L. Madácsy, I. Vámosi
Dátum:	1991
Megjegyzések:	The aims of the present study were to investigate the relationship between severe hypoglycaemia and autonomic dysfunction in diabetic children, and to assess the glycaemic response to an insulin infusion test. In a one year period, 12 of 69 diabetic patients (17%) experienced at least one severe episode of hypoglycaemia, defined as an event which required outside assistance. All patients underwent five cardiovascular autonomic tests. Seven of the hypoglycaemic patients showed three or more abnormal autonomic tests. Among the 57 non-hypoglycaemic diabetics, there was no patient with three or more abnormal tests. In hypoglycaemic diabetics with and without autonomic dysfunction, and in eight healthy age matched subjects an insulin infusion test was performed. A pronounced blood glucose decline and a subnormal increase in heart rate during insulin infusion were obtained in patients with autonomic dysfunction. Thus, severe hypoglycaemia may be due to impaired defence mechanisms against blood glucose decline in diabetic children with autonomic dysfunction. PubMed ID: 1776893 UR: http://www.scopus.com/inward/record.url?eid=2-s2.0-0026343849&partnerID=40&md5=a66b27c10566a3b49b080b557958bf81
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Male INSULIN hypoglycemia human Heart Rate Female Diabetes Mellitus, Insulin-Dependent Autonomic Nervous System Diseases Adolescent school child priority journal insulin infusion insulin dependent diabetes mellitus glucose blood level controlled study clinical article autonomic dysfunction ARTICLE
Megjelenés:	Archives of Disease in Childhood. - 66 : 12 (1991), p. 1438-1441. -
További szerzők:	Madácsy László (Szeged) Vámosi Ildikó
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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