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1.

001-es BibID:BIBFORM041585
Első szerző:Barkai László (gyermekgyógyász)
Cím:Microvascular complications in children and adolescents with type 1 diabetes / L. Barkai, I. Gurieva, A. Striban, S. Tesfaye, L. Czupryniak, B. N. Mankovsky, V. Spallone, I. A. Veresiu, O. Schnell, P. Kempler
Dátum:2012
Megjegyzések:The increasing incidence of type 1 diabetes in children and adolescents emphasizes the need to focus on potential diabetic complications as well. These complications may also occur subclinically and increase at the onset of puberty. In type 1 diabetes, the absence of microvascular complications such as nephropathy, retinopathy, and neuropathy is associated with a life expectancy comperable with that of the general population. Therefore, successful screening and prevention of microvascular complications play a key role in managing younger diabetic patients. The frequency of screening for nephropathy, retinopathy, and neuropathy has been summarized in guidelines, and also depends on age, diabetes duration, and individual risk factors such as family predisposition, puberty, and elevated blood pressure. Optimized glycaemic control plays a key role in efficiency reducing the risk and progression of all microvascular complications. Current consensus recommendations for symptomatic pharmacological treatment of painful diabetic peripheral neuropathy include anticonvulsants; studies have also shown that the thiamine prodrug benfotiamine (S-benzoylthiamine-O-monophosphate) may prevent the formation of advanced glycation end products (AEGs), and may therefore improve early nerve dysfunction in adolescents with type 1 diabetes. The aim of this paper was to review the epidemiology, screening and prevention of microvascular complications from type 1 diabetes in younger patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
diabetes in the young
nephropathy
retinopathy
neuropathy
benfotiamine
külföldön készült közlemény
Megjelenés:Diabetes, Stoffwechsel und Herz. - 21 : 5 (2012), p. 309-315. -
További szerzők:Gurieva, I. Striban, A. Tesfaye, S. Czupryniak, Leszek Mankovsky, Boris N. Spallone, V. Veresiu, I. A. Schnell, Oliver Kempler Péter (1954-) (belgyógyász, diabetológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM024332
Első szerző:Barkai László (gyermekgyógyász)
Cím:Alternations in insulin-like growth factor binding protein-1 and sex hormone binding globulin levels in type 1 diabetic adolescents with microalbuminuria / Laszlo Barkai, Adrienn Tombacz
Dátum:2001
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Megjelenés:Diabetes Care. - 24 : 3 (2001), p. 602-609. -
További szerzők:Tombácz Adrienn
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3.

001-es BibID:BIBFORM024317
Első szerző:Barkai László (gyermekgyógyász)
Cím:Prospective assessment of severe hypoglycaemia in diabetic children and adolescents with impaired and normal awareness of hypoglycaemia / L. Barkai, I. Vámosi, K. Lukács
Dátum:1998
Megjegyzések:To establish whether impaired hypoglycaemic awareness is associated with increased rate of severe hypoglycaemia and to assess clinical predictors of severe episodes without warning symptoms a prospective study of 130 insulin- dependent diabetic children and adolescents was undertaken for 1 year. Using a structured questionnaire, 48 patients reported impaired awareness and 82 reported normal awareness of hypoglycaemia at baseline of the study. The two groups did not differ regarding clinical and metabolic characteristics. Episodes of severe hypoglycaemia were recorded for 1 year. The rate of severe hypoglycaemia was higher in the group with impaired awareness than in the group with normal awareness (p < 0.0001). Of the severe hypoglycaemic episodes, 34.0 % developed without warning symptoms. Patients with impaired awareness experienced more severe episodes without warning symptoms than those with normal awareness (p = 0.0054). Severe hypoglycaemia occurred more frequently in patients with impaired awareness aged 6 years and less (p = 0.0041) than in older counterparts. Impaired awareness reported at baseline [adjusted odds ratio (OR): 5.8; p = 0.0021], age 6 years or less (3.4; p = 0.0121), previous severe episode (4.8; p = 0.0043) and more than 5 % of home blood glucose readings 3.3 mmol/l or less in the preceding month (4.2; p = 0.0211) proved to be independently predictive of severe hypoglycaemic events without warning symptoms. In conclusion, impaired hypoglycaemic awareness is associated with an increased rate of severe hypoglycaemia in diabetic children and adolescents. One third of severe episodes developed without warning symptoms. Impaired awareness, young age and recent biochemical or severe hypoglycaemias are independent risk factors for such episodes. Avoidance of hypoglycaemia should be a priority in pre-school children with diabetes.
PubMed ID: 9726591 UR: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031843066&partnerID=40&md5=6239e776d4bfd076f7fb0750140abf5f
http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0031843066
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
Questionnaires
Prospective Studies
Multivariate Analysis
Male
Infant
hypoglycemia
Humans
Hemoglobin A, Glycosylated
Female
Diabetes Mellitus, Type 1
Child, Preschool
Child
awareness
Adolescent
risk management
risk factor
priority journal
patient guidance
patient education
major clinical study
human
controlled study
conference paper
clinical trial
blood glucose monitoring
Type I diabetes
Hypoglycaemic awareness
Hypoglycaemia
CHILDREN
Megjelenés:Diabetologia : Clinical and experimental diabetes and metabolism. - 41 : 8 (1998), p. 898-903. -
További szerzők:Vámosi Ildikó Lukács Katalin
Internet cím:DOI
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4.

001-es BibID:BIBFORM024315
Első szerző:Barkai László (gyermekgyógyász)
Cím:Enhanced progression of urinary albumin excretion in IDDM during puberty / László Barkai, Ildikó Vámosi, Katalin Lukács
Dátum:1998
Megjegyzések:OBJECTIVE - To determine whether the progression of urinary albumin excretion rate (AER) is higher during puberty than before or after this period. RESEARCH DESIGN AND METHODS - A prospective study was conducted in which normoalbuminuric prepubertal (n = 20), pubertal (n = 28), and postpubertal (n = 26) IDDM groups matched for diabetes duration and long- term metabolic control were followed for 3 years. At 6-month intervals, 24-h urine collection was used to determine AER. RESULTS - AER increased significantly over a period of 3 years in the pubertal (P = 0.001) and postpubertal (P = 0.003) subjects but not in prepubertal subjects. The annual progression of AER was significantly higher in the pubertal group than in the prepubertal (P = 0.001) or postpubertal (P = 0.001) groups. Six pubertal, two postpubertal, and none of the prepubertal subjects developed microalbuminuria (AER ?20 ?g/min on two consecutive occasions) over a 3-year period (P = 0.047). Multiple logistic regression analysis showed that the risk of development of microalbuminuria was increased in pubertal subjects compared with the prepubertal and postpubertal subjects (adjusted relative risk [95% CI]: 4.3 [1.5-9.3], P = 0.012. and 2.1 [1.1-5.0]. P = 0.023, respectively). CONCLUSIONS - Puberty represents an independent risk of the development of microalbuminuria in diabetes. This finding suggests that the endocrine changes of puberty lead to an accelerated process of early kidney damage in diabetes. In pediatric diabetes care, screening for microalbuminuria is needed soon after the onset of puberty.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Triglycerides
Risk Factors
Regression Analysis
puberty
Prospective Studies
Male
Humans
Follow-Up Studies
Female
DISEASE PROGRESSION
Diabetes Mellitus, Type 1
Cholesterol
Child
Body Constitution
Blood Pressure
Albuminuria
Adolescent
urinary excretion
Treatment Outcome
subcutaneous drug administration
major clinical study
insulin treatment
insulin dependent diabetes mellitus
human
diabetic nephropathy
diabetes mellitus
controlled study
ARTICLE
somatomedin C
INSULIN
albumin
Megjelenés:Diabetes Care. - 21 : 6 (1998), p. 1019-1023. -
További szerzők:Vámosi Ildikó Lukács Katalin
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
szerző által megadott URL
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5.

001-es BibID:BIBFORM024331
Első szerző:Barkai László (gyermekgyógyász)
Cím:Puberty as a risk factor for diabetic neuropathy / László Barkai, Péter Kempler
Dátum:2000
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Risk Factors
puberty
Humans
Hand Strength
Diabetic Neuropathies
Diabetes Mellitus, Type 1
Child
Adolescent
risk factor
PREDICTION
perceptive threshold
note
nerve function
major clinical study
human
Holter monitoring
heart rate variability
disease duration
DIABETIC NEUROPATHY
autonomic neuropathy
Megjelenés:Diabetes Care. - 23 : 7 (2000), p. 1044-1045. -
További szerzők:Kempler Péter (1954-) (belgyógyász, diabetológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM041459
Első szerző:Buzzetti, Raffaella
Cím:C-peptide response and HLA genotypes in subjects with recent-onset type 1 diabetes after immunotherapy with DiaPep277 : an exploratory study / Raffaella Buzzetti, Simona Cernea, Antonio Petrone, Marco Capizzi, Marialuisa Spoletini, Simona Zampetti, Chiara Guglielmi, Chiara Venditti, Paolo Pozzilli, DiaPep Trialists Group
Dátum:2011
ISSN:0012-1797
Megjegyzések:OBJECTIVETo investigate whether lower risk HLA class II genotypes would influence the efficacy of DiaPep277 therapy in protecting ?-cell function evaluated by C-peptide secretion in recent-onset type 1 diabetic subjects.RESEARCH DESIGN AND METHODSData were collected from type 1 diabetic subjects enrolled in multicenter phase II studies with a randomized, double-blind, and placebo-controlled design in whom fasting and stimulated C-peptide levels were measured. HLA genotypes were classified in high, moderate, and low risk categories.RESULTSA total of 146 subjects (aged 4.3 to 58.5 years) were enrolled, including 76 children (<18 years old) and 70 adults. At baseline, there was a significant increase in fasting, maximal, and area under the curve (AUC) C-peptide from high to moderate and low risk HLA genotypes in adults (P for trend <0.04) but not in children. Children showed a decrease of the three parameters over time regardless of therapy and HLA genotype. DiaPep277-treated adults with low risk genotype had significantly higher maximal and AUC C-peptide versus placebo at 12 months (0.04 ? 0.07 vs. ?0.28 ? 0.09 nmol/L, P < 0.01, and 0.53 ? 1.3 vs. ?4.59 ? 1.5 nmol/L, P < 0.05, respectively). In the moderate risk genotype group, ?maximal and AUC C-peptide values were significantly higher in DiaPep277-treated versus placebo-treated patients (P < 0.01 and P < 0.05, respectively).CONCLUSIONSThis exploratory study demonstrates that type 1 diabetic adults with low and moderate risk HLA genotypes benefit the most from intervention with DiaPep277; the only subgroup with an increase of C-peptide at 12 months after diagnosis was the low risk DiaPep277-treated subgroup.
Tárgyszavak:Orvostudományok Klinikai orvostudományok módszertani levél
open access article
feltáró tanulmány
külföldön készült közlemény
Megjelenés:Diabetes. - 60 : 11 (2011), p. 3067-3072. -
További szerzők:Cernea, Simona Petrone, Antonio Capizzi, Marco Spoletini, Marialuisa Zampetti, Simona Guglielmi, Chiara Venditti, Chiara Pozzilli, Paolo Barkai László (1958-) (gyermekgyógyász) DiaPep Trialists Group
Internet cím:Szerző által megadott URL
DOI
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7.

001-es BibID:BIBFORM041484
Első szerző:Ceriello, Antonio
Cím:Diabetes as a case study of chronic disease management with a personalized approach : the role of a structured feedback loop / Antonio Ceriello, László Barkai, Jens Sandahl Christiansen, Leszek Czupryniak, Ramon Gomis, Kari Harno, Bernhard Kulzer, Johnny Ludvigsson, Zuzana Némethyová, David Owens, Oliver Schnell, Tsvetalina Tankova, Marja-Riitta Taskinen, Bruno Vergèsm, Raimund Weitgasser, Johan Wens
Dátum:2012
ISSN:0168-8227
Megjegyzések:As non-communicable or chronic diseases are a growing threat to human health and economic growth, political stakeholders are aiming to identify options for improved response to the challenges of prevention and management of non-communicable diseases. This paper is intended to contribute ideas on personalized chronic disease management which are based on experience with one major chronic disease, namely diabetes mellitus. Diabetes provides a pertinent case of chronic disease management with a particular focus on patient self-management. Despite advances in diabetes therapy, many people with diabetes still fail to achieve treatment targets thus remaining at risk of complications. Personalizing the management of diabetes according to the patient's individual profile can help in improving therapy adherence and treatment outcomes. This paper suggests using a six-step cycle for personalized diabetes (self-)management and collaborative use of structured blood glucose data. E-health solutions can be used to improve process efficiencies and allow remote access. Decision support tools and algorithms can help doctors in making therapeutic decisions based on individual patient profiles. Available evidence about the effectiveness of the cycle's constituting elements justifies expectations that the diabetes management cycle as a whole can generate medical and conomic benefit.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Diabetes Research And Clinical Practice. - 98 : 1 (2012), p. 5-10. -
További szerzők:Christiansen, Jens Sandahl Czupryniak, Leszek Gomis, Ramon Harno, Kari Kulzer, Bernhard Ludvigsson, Johnny Némethyová, Zuzana Owens, David Schnell, Oliver Tankova, Tsvetalina Taskinen, Marja-Riitta Vergèsm, Bruno Weitgasser, Raimund Wens, Johan Barkai László (1958-) (gyermekgyógyász)
Internet cím:Szerző által megadott URL
DOI
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8.

001-es BibID:BIBFORM024338
Első szerző:Gyürüs Éva
Cím:Dynamic changes in the trends in incidence of type 1 diabetes in children in Hungary (1978-98) / Éva Gyürüs and The Hungarian Childhood Diabetes Epidemiology Study Group
Dátum:2002
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pediatric diabetes. - 3 : 3 (2002), p. 194-199. -
További szerzők:Barkai László (1958-) (gyermekgyógyász) The Hungarian Childhood Diabetes Epidemiology Study Group
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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9.

001-es BibID:BIBFORM042183
Első szerző:Lukács Andrea (oktató)
Cím:Reduced physical fitness in children and adolescents with type 1 diabetes / Andrea Lukács, Krisztina Mayer, Eleonóra Juhász, Beatrix Varga, Bertalan Fodor, László Barkai
Dátum:2012
ISSN:1399-543X
Megjegyzések:AIMS: To evaluate motor performance and cardiorespiratory function in youths with type 1 diabetes in comparison with age-matched control groups and to analyze the influence of physical activity level, anthropometric and physical fitness parameters on long-term metabolic control.METHODS:106 youths with diabetes and 130 healthy youths aged 8-18 were assessed by the Eurofit test regarding motor performances, cardiorespiratory fitness (VO2max), skinfold thickness, and body mass index. Physical activity level was assessed through the use of questionnaires. Predictors of physical fitness and metabolic control were determined with regression analysis.RESULTS:There were no differences either in body composition or in physical activity level, but younger girls with diabetes had impaired results in speed of upper limb movement, abdominal muscle strength, upper body strength, running speed, and VO2max ; older girls with diabetes had poor results in speed of upper limb movement, abdominal muscle strength, upper body strength and VO2max . Younger boys with diabetes had impaired results in speed of upper limb movement, flexibility, static strength of hand, and abdominal muscle strength; and older boys with diabetes had poor results in speed of upper limb movement, flexibility, abdominal muscle strength, upper body strength, and VO2max compared with control groups. Older age, female gender, lower physical activity level, and higher HbA1c were significant independent predictors of poorer VO2max. Better VO2max proved to be the single predictor of favorable HbA1c .CONCLUSIONS:Youths with diabetes have reduced fitness parameters. Efforts should be carried out to improve physical fitness as part of treatment and care of children and adolescents with type 1 diabetes.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pediatric Diabetes. - 13 : 5 (2012), p. 432-437. -
További szerzők:Mayer Krisztina Juhász Eleonóra Varga Beatrix Fodor Bertalan Barkai László (1958-) (gyermekgyógyász)
Pályázati támogatás:TAMOP-4.2.1.B-10/2/KONV-2010-0001
TÁMOP
Internet cím:Szerző által megadott URL
DOI
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10.

001-es BibID:BIBFORM042196
Első szerző:Lukács Andrea (oktató)
Cím:Health-related quality of life of youths with type 1 diabetes : reliability and validity of the Hungarian version of the PedsQL 3.0 diabetes module / Andrea Lukács, Beatrix Varga, Szabolcs Barótfi, Emőke Kiss-Tóth, László Barkai
Dátum:2012
Megjegyzések:Background: In the routine care of diabetes, mostly the clinical parameters are controlled and little attention is paid to the quality of life assessment. A questionnaire must be culturally adapted in the country where it is intended to be used. The aim of the study was to assess health-related quality of life in youths with type 1 diabetes using the PedsQL 3.0 Diabetes Module and to evaluate the psychometric properties in patient and control subjects. Methods: Diabetes and Generic Module were administered to 355 youths with type 1 diabetes (8-18 y/o) and their parents. Generic Module was completed by 294 age-matched control participants and their parents. Feasibility, internal consistency reliability, reproducibility, convergent, discriminant and concurrent validities were evaluated. Results: Minimal floor and moderate ceiling effects and hardly any missing item responses proved the feasibility. Cronbach's ? was gretaer than 0.70 in all subscales and met the criterion of 0.90 in total-items reliability. Testretest reliability was demonstrated with Pearson coefficients. We found good agreement between the children's and parents's answers, although parents underestimated their diabetic children in all subscales. The instrument was able to differentiate between the health-related quality of life of optimal, suboptimal and high risk metabolic control. The Diabetes Modul subscales and the Generic Module total scale correlated well, except the worry subscale. Conclusions: Diabetic youths had similar health-related quality of life as their non-diabetic peers. Parents underestimated their diabetic child's quality of life, but this was not the case in the healthy population. Both diabetic and healthy boys had better perception of quality of life than girls. The nationally adapted version of the Pediatric Quality of Life Inventory 3.0 Diabetes Module designed for children and adolescents was reliable and valid instrument for assessing health-related quality of life in youths with type 1 diabetes.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Diabetes & Metabolism. - 3 : 4 (2012), p. 1000191. -
További szerzők:Varga Beatrix Barótfi Szabolcs Kiss-Tóth Emőke Barkai László (1958-) (gyermekgyógyász)
Pályázati támogatás:TÁMOP-4.2.1.B-10/2/KONV-2010-0001
TÁMOP
Internet cím:Szerző által megadott URL
DOI
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11.

001-es BibID:BIBFORM024362
Első szerző:Schloot, Nanette C.
Cím:Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1 : two prospective, randomized, double-blind phase II trials / Nanette C. Schloot, Guido Meierhoff, Csaba Lengyel, Gyözö Vándorfi, József Takács, Pál Pánczél, László Barkai, László Madácsy, Tamás Oroszlán, Peter Kovács, Gábor Sütö, Tadej Battelino, Nora Hosszufalusi, György Jermendy
Dátum:2007
Megjegyzések:Background: Aim of this trial was to test whether heat shock protein peptide DiaPep277 treatment in adult and paediatric patients with recent-onset type 1 diabetes (T1D) is safe and whether it can preserve endogenous insulin production. Methods: Two studies were performed in a prospective, multicentre, double-blind, placebo-controlled trial. Fifty adult (study p520, aged 16-44 years) and 49 paediatric patients (study p521, 4-15 years) with recent-onset T1D were treated subcutaneously at four different time points with 0.2 mg or 1.0 mg DiaPep277 versus placebo and followed for 18 months. Adult patients were treated with 0.2 mg, 1.0 mg or 2.5 mg DiaPep277 versus placebo. Stimulated C-peptide served as readout for functional ?-cell-mass. Results: DiaPep277-treatment was not associated with severe side effects. No differences were found in placebo and DiaPep277 treated groups. In adults, a modest trend towards better maintenance of ?-cell function was observed in the 0.2 mg and 1.0 mg group, while there was significant loss of stimulated C-peptide in the placebo and 2.5 mg group. Paediatric patients with low HLA risk showed stable C-peptide levels until 13 months upon treatment with 1 mg DiaPep277. Despite similar stimulated C-peptide levels at baseline, children exhibited a more pronounced loss of ?-cell function over 18 months than adults (p = 0.0003). Conclusion: Administration of DiaPep277 seems safe and may have beneficial effects on C-peptide levels over time in some patients with T1D, but this finding was not accompanied by reduced HbA<sub>1c</sub> or insulin requirement. Studies with more patients and longer follow-up are needed to further study the effect of DiaPep277.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
PEPTIDES
Islets of Langerhans
INSULIN-SECRETING CELLS
INSULIN
Injections, Subcutaneous
Hypoglycemic Agents
Humans
HLA Antigens
Hemoglobin A, Glycosylated
Drug Therapy, Combination
Double-Blind Method
Dose-Response Relationship, Drug
Diabetes Mellitus, Type 1
Child
C-peptide
AUTOANTIBODIES
Adult
Adolescent
urticaria
unspecified side effect
randomized controlled trial
protein blood level
priority journal
phase 2 clinical trial
pancreas islet cell function
pancreas islet beta cell
multiple drug dose
multicenter study
menstrual irregularity
Male
major clinical study
insulin synthesis
insulin dependent diabetes mellitus
injection site dermatitis
immunotherapy
hypoglycemia
human
HLA matching
high risk population
hemoglobin blood level
Female
drug tolerance
drug safety
drug fever
drug dose increase
drug dose comparison
double blind procedure
dizziness
controlled study
controlled clinical trial
clinical trial
cell density
ARTICLE
antibody titer
Age Distribution
unclassified drug
placebo
peptide p277
mannitol
HLA DR3 antigen
HLA DR antigen
hemoglobin A1c
heat shock protein 60
diapep277
C peptide
antidiabetic agent
Type 1 diabetes mellitus
PREVENTION
Human trials
Hsp60
HbA<sub>1c</sub>
Megjelenés:Diabetes/metabolism research and reviews. - 23 : 4 (2007), p. 276-285. -
További szerzők:Meierhoff, Guido Lengyel Csaba (Miskolc) Vándorfi Győző Takács József Pánczél Pál Barkai László (1958-) (gyermekgyógyász) Madácsy László (Szeged) Oroszlán Tamás Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Sütő Gábor Battelino, Tadej Hosszúfalusi Nóra Jermendy György
Internet cím:DOI
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12.

001-es BibID:BIBFORM041463
Első szerző:Török A. (Miskolc)
Cím:Examination of macrovascular complications in type-1 diabetic children and adolescents with transcranial Doppler ultrasonography (P/042/WED) / A. Török, R. Lovász, I. Velkey, A. Valikovics, L. Barkai
Dátum:2011
ISSN:1399-543X
Tárgyszavak:Orvostudományok Klinikai orvostudományok poszter
Poster Sessions - P/042
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pediatric Diabetes. - 12 : Suppl. 15 (2011), 54. p. -
További szerzők:Lovász Rita (Miskolc) Velkey Imre György (1952-) Valikovics Attila Barkai László (1958-) (gyermekgyógyász)
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DOI
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