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001-es BibID:	BIBFORM024316
Első szerző:	Barkai László (gyermekgyógyász)
Cím:	Peripheral sensory nerve dysfunction in children and adolescents with type I diabetes meilitus / Barkai László, Kempler Péter, Vámosi I., Lukács K., Marton A., Keresztes Katalin
Dátum:	1998
Megjegyzések:	The aim of the present study was to investigate peripheral sensory nerve function in diabetic children and adolescents without neurological symptoms. Ninety-two children and adolescents with Type 2 (insulin-dependent) diabetes mellitus (mean JSD age: 14.2 ? 2.1 years, diabetes duration: 5.8 ? 3.0 years) and 80 healthy control subjects (age: 13.8 ? 2.2 years) matched for age, sex, body mass index, and height standard deviation score were involved in the study. Using a sine-wave transcutaneous stimulator current perception threshold (CPT) testing at 2000, 250 and 5 Hz was performed or the left median and peroneal nerves. Diabetic children had increased CPT at 2000 Hz on both nerves as compared to the control group (median (interquartile range), median nerve: 2.43 (2.20-3.43) vs 1.80 (1.51-2.60) mA, p = 0.02; peroneal nerve: 3.51 (2.81-4.82) vs 2.70 (2.04-3.70) mA, p = 0.01). Twenty-one (23 %) of patients had CPT values higher than that of any healthy individual. Of these, elevated CPT was observed in 9 (9.8 %) patients on the median nerve, in 8 (8.7 %) patients on the peroneal nerve, land in 4 (4.3 %) patients on both median and peroneal nerves. Using multiple logistic regression analysis, worse long-term metabolic control and advanced puberty were independently predictive of peripheral sensory nerve dysfunction as the dependent variable (adjusted OR (95 % Cl): 3.4 (1.2-6.2), p = 0.01, and 2.8 (1.1-5.6), p = 0.03, respectively). In conclusion, evidence of peripheral sensory nerve dysfunction is not rare in children and adolescents with diabetes and can be demonstrated by CPT testing in asymptomatic patients. Poor metabolic control is a risk factor for such subclinical neuropathy, and pubertal development may be involved in the pathogenesis of diabetic deripheral neuropathy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Reference Values Peripheral Nerves PERCEPTION Male Logistic Models Humans Female Electric Stimulation electric conductivity Diabetic Neuropathies Diabetes Mellitus, Type 1 Child Adolescent transcutaneous nerve stimulation sensory neuropathy school child risk factor peroneus nerve Peripheral neuropathy onset age median nerve major clinical study insulin dependent diabetes mellitus Incidence human DIABETIC NEUROPATHY ARTICLE Insulin-dependent diabetes mellitus CHILDREN Adolescents
Megjelenés:	Diabetic Medicine. - 15 : 3 (1998), p. 228-233. -
További szerzők:	Kempler Péter (1954-) (belgyógyász, diabetológus) Vámosi Ildikó Lukács K. Marton, A. Keresztes Katalin
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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001-es BibID:	BIBFORM024302
Első szerző:	Barkai László (gyermekgyógyász)
Cím:	Physical work capacity in diabetic children and adolescents with and without cardiovascular autonomic dysfunction / L. Barkai, M. Peja, I. Vámosi
Dátum:	1996
Megjegyzések:	The aim of the present study was to evaluate the influence of autonomic nervous system dysfunction on work capacity in children and adolescents with Type 1 (insulin-dependent) diabetes. Fifteen patients with autonomic dysfunction (abnormal autonomic tests, age: 14.9?2.3 years), 35 patients without autonomic dysfunction (normal autonomic tests, age: 15.2?2.5 years), and 25 non-diabetic subjects (age: 15.0?2.3 years) were investigated. Resting heart rate, deep breathing heart rate variation, standing/lying heart rate ratio, decrease in blood pressure during orthostasis, and increase in blood pressure during sustained handgrip were used to assess cardiovascular autonomic dysfunction. Physical work capacity at heart rate of 170 min<sup>-1</sup> was determined by bicycle ergometry. Glycated haemoglobin level was higher in patients with than without autonomic dysfunction (12.3?3.1 vs 9.4?2.9%, p = 0.04). Patients with autonomic dysfunction had significantly lower physical work capacity at heart rate of 170 min<sup>-1</sup> than those with normal autonomic function or non-diabetic subjects (0.81?0.12 vs 1.49?0.16 and 1.54?0.20 W kg<sup>-1</sup> p = 0.01). Physical work capacity at heart rate of 170 min<sup>-1</sup> was related to glycated haemoglobin level (r = -0.55, p = 0.01), to resting heart rate (r = 0.57, p =0.01), and to deep breathing heart rate variation (r = 0.51, p 0.02). In conclusion, impaired work capacity is associated with poor blood glucose control and cardiovascular autonomic dysfunction. Autonomic tests can help to identify those patients who may need special consideration during exercise. PubMed ID: 8689847 UR: http://www.scopus.com/inward/record.url?eid=2-s2.0-0029969535&partnerID=40&md5=a04f51d2cacb00d6d7e8cf8b711e215a http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0029969535
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Respiration Reference Values Posture Male Humans Heart Rate Female Exertion Exercise Test Electrocardiography Diabetic Angiopathies Diabetes Mellitus, Type 1 Confidence Intervals Child Blood Pressure Adolescent Work capacity school child major clinical study insulin dependent diabetes mellitus human diabetes control controlled study autonomic nervous system function autonomic dysfunction ARTICLE glycosylated hemoglobin diabetes mellitus CHILDREN Autonomic function Adolescents
Megjelenés:	Diabetic Medicine. - 13 : 3 (1996), p. 254-258. -
További szerzők:	Peja Márta Vámosi Ildikó
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM024352
Első szerző:	Barkai László (gyermekgyógyász)
Cím:	Association of angiotensin-converting enzyme DD genotype with 24-h blood pressure abnormalities in normoalbuminuric children and adolescents with Type 1 diabetes / L. Barkai, A. Soós, I. Vámosi
Dátum:	2005
Megjegyzések:	Aims: To assess the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in children and adolescents with Type 1 diabetes and to evaluate the association between ACE genotype and blood pressure (BP). Methods: ACE genotypes were assessed in 124 normoalbuminuric, clinically normotensive Type 1 diabetic children and adolescents and 120 non-diabetic controls using polymerase chain reaction. Twenty-four-hour ambulatory BP monitoring was undertaken in all patients. Results: ACE genotypes distributed in patients as follows: 34 (27%) DD, 57 (46%) ID, 33 (27%) II. The distribution was similar in the control group: DD in 28% (33), ID in 45% (54), and II in 27% (33). Patients with DD genotype had higher mean 24-h diastolic BP (73.8 ? 6.2 vs. 70.2 ? 5.0 and 69.7? 6.3 mmHg; P = 0.005) and lower diurnal variation in BP (11.8 ? 4.6 vs. 14.2 ? 4.2 and 14.8 ? 4.3%; P = 0.011) compared with ID and II groups. Four patients in the DD group proved to be non-dipper compared with one in the ID and none in the II group (P = 0.026). Twenty-four-hour diastolic blood pressure was independently predictive for AER as dependent variable in the DD genotype patient group (r<sup>2</sup> = 0.12, P = 0.03). Conclusions: Children and adolescents with Type 1 diabetes do not differ from the non-diabetic population regarding the I/D polymorphism of the ACE gene. ACE gene polymorphism is associated with BP abnormalities in normotensive and normoalbuminuric children and adolescents with Type 1 diabetes. ? 2005 Diabetes UK. PubMed ID: 16026372 UR: http://www.scopus.com/inward/record.url?eid=2-s2.0-22644435103&partnerID=40&md5=b194d518803646e997d3ce35e7e2f22d http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-22644435103
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Sequence Deletion Polymorphism, Genetic Peptidyl-Dipeptidase A Male Hungary Humans Genotype Female Diabetes Mellitus, Type 1 Child Blood Pressure Adolescent school child proteinuria polymerase chain reaction major clinical study insulin dependent diabetes mellitus human genetic polymorphism gene insertion Gene Deletion diastolic blood pressure controlled study circadian rhythm blood pressure monitoring ARTICLE Adult INSULIN dipeptidyl carboxypeptidase Children and adolescents Angiotensin-converting enzyme gene polymorphism Ambulatory blood pressure measurement
Megjelenés:	Diabetic Medicine. - 22 : 8 (2005), p. 1054-1059. -
További szerzők:	Soós Andrea Vámosi Ildikó
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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