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001-es BibID:	BIBFORM024404
Első szerző:	Barkai László (gyermekgyógyász)
Cím:	Investigation of subclinical signs of autonomic neuropathy in the early stage of childhood diabetes / László Barkai, László Madácsy, László Kassay
Dátum:	1990
Megjegyzések:	It has been suggested that subclinical signs of neuropathy appear earlier than microvascular complications of diabetes. To evaluate the occurrence of autonomic nervous system dysfunction in the early stage of childhood diabetes, subclinical signs of autonomic neuropathy (resting heart rate, hyperventilatory arrhythmia, standing/lying heart rate ratio, orthostatic decrease in blood pressure, and increase in blood pressure during sustained handgrip) were investigated in 54 children with type 1 diabetes divided into three groups: 14 recent-onset diabetics (3 weeks after the diagnosis), 20 diabetics in the remission phase, and 20 patients after the remission phase. 30 healthy age-matched children were used as control group. The mean resting heart rates of the diabetic groups in the remission phase and after the remission phase were significantly higher than those in the healthy control group (81.7 ? 5/min and 88.5 ? 6/min vs. 72.2 ? 8/min; p < 0.01). The hyperventilatory arrhythmia in the group of diabetic children after the remission phase in comparison with the control group was significantly decreased (29.1 ? 4/min vs. 22.7 ? 3/min; p < 0.01). In a few cases of the recent-onset diabetic group, the increase in resting heart rate, the decrease in hyperventilatory arrhythmia, and the standing/lying heart rate ratio proved to be significant. In the remission phase, the same parameters showed abnormal values in one third to one fifth of the children. In the diabetic group after the remission phase, these parameters were established as pathologic in one half to one fifth of the children, and in some cases, the orthostatic decrease in blood pressure and the increase in blood pressure during sustained handgrip were pathognomic as well. These results indicate that the initial, functional disturbances of the autonomic nervous system may appear early during the course of childhood diabetes and they emphasize the necessity to search for subclinical neuropathy in diabetic children.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Male INSULIN human Heart Rate Female Diabetic Neuropathies Diabetes Mellitus, Insulin-Dependent Child Blood Pressure Autonomic Nervous System Diseases Arrhythmia school child priority journal major clinical study insulin dependent diabetes mellitus DIABETIC NEUROPATHY ARTICLE Adolescent insulin zinc suspension Diabetes children, diabetic autonomic neuropathy
Megjelenés:	Hormone Research. - 34 : 2 (1990), p. 54-59. -
További szerzők:	Madácsy László (Szeged) Kassay László
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat szerző által megadott URL
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001-es BibID:	BIBFORM024349
Első szerző:	Madácsy László (Szeged)
Cím:	Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus / L. Madácsy, L. Barkai, A. Sánta, D. Krikovszky
Dátum:	2004
Megjegyzések:	Objective: The recently observed increase in the incidence of type 1 diabetes mellitus (Type 1 DM) suggests a major role of environmental factors in the etiopathogenesis of the disease. The individual variation in cytochrome P<sub>450</sub>IID6 may influence the individual susceptibility to environmentally linked diseases. We aimed to evaluate the prevalence of cytochrome P<sub>450</sub>IID6 phenotypes in Hungarian children with Type 1 DM (n = 69) compared to healthy controls (n = 100). Methods: Debrisoquine was administered orally and debrisoquine hydroxylation phenotype was determined as a metabolic ratio of urinary recovered debrisoquine and 4-hydroxydebrisoquine. Results: Eight of the 100 healthy subjects (8%) and 15 of the 69 diabetic children (22%) (p < 0.05) had cytochrome P<sub>450</sub>IID6 poor metabolizer phenotype (metabolic ratio ?12.6). Conclusion: Cytochrome P <sub>450</sub>IID6's activity may play a role in the development of Type 1 DM. Copyright ? 2004 S. Karger AG, Basel.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban PHENOTYPE Hydroxylation Humans Diabetes Mellitus, Type 1 Debrisoquin Cytochrome P-450 CYP2D6 Child, Preschool Child Case-Control Studies priority journal PREVALENCE OXIDATION Male major clinical study insulin dependent diabetes mellitus human Female evaluation ethnic group drug urine level drug metabolism drug hydroxylation drug distribution controlled study childhood disease ARTICLE Debrisoquine cytochrome P450 2D6 4 hydroxydebrisoquine Type 1 diabetes mellitus Cytochrome P<sub>450</sub>IID6
Megjelenés:	Hormone Research. - 61 : 4 (2004), p. 176-179. -
További szerzők:	Barkai László (1958-) (gyermekgyógyász) Sánta Anna Krikovszky Dóra
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat szerző által megadott URL
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