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001-es BibID:BIBFORM024364
Első szerző:Szabó László
Cím:Urinary flow disturbance as an early sign of autonomic neuropathy in diabetic children and adolescents' / Laszlo Szabo, Laszlo Barkai, Bela Lombay
Dátum:2007
Megjegyzések:Aims: Urinary bladder dysfunction is a frequent complication of diabetes mellitus in adults. The aim of this study is to determine the early disturbances of the detrusor contractility in children, and adolescents with type 1 diabetes. Materials and Methods: The bladder urine flow parameters were investigated in 37 children with type 1 diabetes, 10/37 with cardiovascular autonomic dysfunction (CAD) voided 482 ? 128 mils (Group A), 27/37 without CAD voided 258 ? 52 mils (Group B). From an earlier uroflow screening study 20 healthy children formed group control A, who had voided 488 ? 94 mils, and another 30 healthy children formed group control B, who had voided 260 ? 50 mils. The compared groups were matched for voided volume, age, weight, and height. There was no evidence of urinary tract abnormalities in any of the children. Results: Time to maximum flow was longer in both diabetic groups as compared with controls (P < 0.01), and the acceleration (the ratio of maximum flow and the time to maximum flow) of diabetics was significantly lower (P < 0.01). Bladder emptying was complete in each subject. Bladder wall disturbances were not seen by ultrasound. Conclusions: The decreased acceleration of detrusor muscle contraction may be interpreted as an early sign of autonomic neuropathy in children and adolescent with type 1 diabetes, even in patients without CAD. Clinicians may be able to determine autonomic neuropathy by using uroflowmetry that is easy to perform, sensitive, reproducible, and needs only a child's minimal cooperation. ? 2006 Wiley-Liss, Inc.
PubMed ID: 17078072 UR: http://www.scopus.com/inward/record.url?eid=2-s2.0-34247117315&partnerID=40&md5=bd1e153db61a720d281c7d143a09fe61
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Urodynamics
Urinary Bladder
Prospective Studies
Muscle, Smooth
Male
Humans
Heart Rate
Female
Diabetic Neuropathies
Diabetes Mellitus, Type 1
Child
Blood Pressure
Autonomic Nervous System Diseases
Adolescent
Uroflowmetry
urine incontinence
Sensitivity analysis
reproducibility
onset age
muscle contractility
micturition
insulin dependent diabetes mellitus
human
Early Diagnosis
DIABETIC NEUROPATHY
detrusor dyssynergia
COOPERATION
controlled study
clinical article
cardiovascular disease
Body Weight
Body Height
bladder dysfunction
ARTICLE
Adult
Urine flow acceleration
Diabetic cystopathy
diabetes mellitus
Megjelenés:Neurourology and urodynamics. - 26 : 2 (2007), p. 218-221. -
További szerzők:Barkai László (1958-) (gyermekgyógyász) Lombay Béla Jr.
Internet cím:DOI
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